{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T08:29:50Z","timestamp":1782203390096,"version":"3.54.5"},"reference-count":50,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2017,2,13]]},"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To describe the prevalence of brain MRI incidental findings (IF) in a cohort of cognitively normal first-degree descendants of patients with Alzheimer's disease (AD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Cross-sectional observational study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>All scans were obtained with a 3.0\u2005T scanner. Scans were evaluated by a single neuroradiologist and IF recorded and categorised. The presence of white matter hyperintensities (WMH) was determined with the Fazekas scale and reported as relevant if \u22652.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>575 participants (45\u201375\u2005years) underwent high-resolution structural brain MRI. Participants were cognitively normal and scored over the respective cut-off values in all the following neuropsychological tests: Mini-Mental State Examination (\u226526), Memory Impairment Screen (\u22656), Time Orientation Subtest of the Barcelona Test II (\u226568), verbal semantic fluency (naming animals \u226512). Clinical Dementia Rating (CDR) had to be 0.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>155 participants (27.0%) presented with at least one IF. Relevant WMH were present in 7.8% of the participants, and vascular abnormalities, cyst and brain volume loss in 10.7%, 3.1% and 6.9% of the study volunteers, respectively. Neoplastic brain findings were found in 2.4% of participants and within these, meningiomas were the most common (1.7%) and more frequently found in women. A positive correlation between increasing age and the presence of IF was found. Additionally, brain atrophy greater than that expected by age was significantly more prevalent in participants without a parental history of AD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Brain MRIs of healthy middle-aged participants show a relatively high prevalence of IF even when study participants have been screened for subtle cognitive alterations. Most of our participants are first-degree descendants of patients with AD, and therefore these results are of special relevance for novel imaging studies in the context of AD prevention in cognitively healthy middle-aged participants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>NCT02198586.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2016-013215","type":"journal-article","created":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T01:10:39Z","timestamp":1490404239000},"page":"e013215","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Incidental findings on brain MRI of cognitively normal first-degree descendants of patients with Alzheimer's disease: a cross-sectional analysis from the ALFA (Alzheimer and Families) project"],"prefix":"10.1136","volume":"7","clinical-trial-number":[{"clinical-trial-number":"nct01835717","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct02198586","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct02198586","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Anna","family":"Brugulat-Serrat","sequence":"first","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Rojas","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain"},{"name":"Unit of Human Anatomy and Embryology, Faculty of Medicine, Department of Morphological Sciences, Universitat Aut\u00f2noma de Barcelona, Cerdanyola del Vall\u00e8s, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Bargall\u00f3","sequence":"additional","affiliation":[{"name":"Magnetic Resonance Imaging Core Facility, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"},{"name":"Centre M\u00e8dic Diagn\u00f2stic Alomar, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Conesa","sequence":"additional","affiliation":[{"name":"Servicio de Neurocirug\u00eda, Hospital del Mar, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Minguill\u00f3n","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Fauria","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Gramunt","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Molinuevo","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Domingo","family":"Gispert","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,3,24]]},"reference":[{"key":"2025101814285880000_7.3.e013215.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.12.004"},{"key":"2025101814285880000_7.3.e013215.2","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2007.19.9.1498"},{"key":"2025101814285880000_7.3.e013215.3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b3016"},{"key":"2025101814285880000_7.3.e013215.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-720X.2008.00275.x"},{"key":"2025101814285880000_7.3.e013215.5","unstructured":"Radiologists TRCo. 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