{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:34:23Z","timestamp":1787164463713,"version":"build-2736575974"},"reference-count":19,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2017,5,19]]},"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To present a snapshot of experimental cardiovascular research with a focus on geographical and temporal patterns of early termination due to poor accrual.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>The Aggregate Analysis of ClinicalTrials.gov (AACT) database, reflecting ClinicalTrials.gov as of 27 March 2016.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>The AACT database was searched for all cardiovascular clinical trials that started from January 2006 up to December 2015.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirteen thousand and seven hundred twenty-nine cardiovascular trials were identified. Of these, 8900 (65%) were classified as closed studies. Globally, 11% of closed trials were terminated. This proportion varied from 9.6% to 14% for trials recruiting from Europe and Americas, respectively, with a slightly decreasing trend (p=0.02) over the study period. The most common reason for trials failing to complete was poor accrual (41%). Intercontinental trials exhibited lower figures of poor accrual as the reason for their early stopping, as compared with trials recruiting in a single continent (28% vs 44%, p=0.002).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Poor accrual significantly challenges the successful completion of cardiovascular clinical trials. Findings are suggestive of a positive effect of globalisation of cardiovascular clinical research on the achievement of enrolment goals within a reasonable time frame.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2016-013482","type":"journal-article","created":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T20:20:10Z","timestamp":1497558010000},"page":"e013482","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Early termination of cardiovascular trials as a consequence of poor accrual: analysis of ClinicalTrials.gov 2006\u20132015"],"prefix":"10.1136","volume":"7","author":[{"given":"Ileana","family":"Baldi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Lanera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Berchialla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Gregori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,6,15]]},"reference":[{"key":"2024051611283681000_7.6.e013482.1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.111.965707"},{"key":"2024051611283681000_7.6.e013482.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-6175.2002.01094.x"},{"key":"2024051611283681000_7.6.e013482.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.6.2892"},{"key":"2024051611283681000_7.6.e013482.4","doi-asserted-by":"publisher","DOI":"10.1177\/1740774514558307"},{"key":"2024051611283681000_7.6.e013482.5","doi-asserted-by":"crossref","unstructured":"Stensland KD , McBride RB , Latif A , et al . 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