{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:37:47Z","timestamp":1788669467635,"version":"build-2803163510"},"reference-count":33,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2017,12,6]]},"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The aim of this paper is to provide a protocol for a systematic review assessing the effectiveness of evidence from randomised controlled trials comparing fetal alcohol spectrum disorders pharmacological and non-pharmacological interventions with placebo\/dummy interventions or usual standards of care in children and adolescents (&lt;18 years old).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>The following electronic databases will be searched: Medline (Ovid), Cumulative Index of Nursing and Allied Health Plus with Full text (EBSCO), Cochrane Central Register of Controlled Trials (Cochrane Library\u2014Wiley), PsycINFO (ProQuest) and Proquest DissertationsandTheses will be searched from inception to March 2017 for relevant citations of published trials using individualised search strategies prepared for database. We will also search the reference lists of relevant articles and conference proceedings. Two reviewers will independently assess each study against predetermined inclusion\/exclusion criteria and extract data including population characteristics, types and duration of interventions and outcomes from included trials. Internal validity will be assessed using the Cochrane Risk of Bias Tool. Primary outcome measures will be improvements in symptoms, including: hyperactivity, impulsivity and attention as measured by standard rating scales. Secondary outcome measures will include improvements in physical and mental health domains, as well as cognitive, behavioural, social and educational skills as measured by rating scales, standardised psychometric tests of IQ and memory, grade repetition, literacy tests and diagnosis of mental health disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Ethical approval will not be obtained since it is not required for systematic reviews as there are no concerns regarding patient privacy. The results of this review will be disseminated through publication in a peer-review journal and presented at relevant conferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.crd.york.ac.uk\/PROSPERO\/display_record.php?ID=CRD42013005996\" ext-link-type=\"uri\">CRD42013005996<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2016-013775","type":"journal-article","created":{"date-parts":[[2018,3,10]],"date-time":"2018-03-10T02:25:23Z","timestamp":1520648723000},"page":"e013775","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Effectiveness of evidence-based treatments of fetal alcohol spectrum disorders in children and adolescents: a systematic review protocol"],"prefix":"10.1136","volume":"8","author":[{"given":"Deepa","family":"Singal","sequence":"first","affiliation":[{"name":"Manitoba Centre for Health Policy, Department of Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantalle","family":"Menard","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine J","family":"Neilson","sequence":"additional","affiliation":[{"name":"Neil John Maclean Health Sciences Library, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marni","family":"Brownell","sequence":"additional","affiliation":[{"name":"Manitoba Centre for Health Policy, Department of Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Hanlon-Dearman","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Developmental Paediatrics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Chudley","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Developmental Paediatrics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Zarychanski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Critical Care, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Department of Haematology and Medical Oncology, CancerCare Manitoba, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Abou-Setta","sequence":"additional","affiliation":[{"name":"George and Fay Yee Center for Healthcare Innovation, University of Manitoba\/Winnipeg Regional Health Authority, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,3,9]]},"reference":[{"key":"2025121223313054000_8.3.e013775.1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1040302"},{"key":"2025121223313054000_8.3.e013775.2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.141593"},{"key":"2025121223313054000_8.3.e013775.3","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ejmg.2016.09.010","article-title":"Prevalence of alcohol consumption during pregnancy and fetal alcohol spectrum disorders among the general and Aboriginal populations in Canada and the United States","volume":"60","author":"Popova","year":"2017","journal-title":"Eur J Med Genet"},{"key":"2025121223313054000_8.3.e013775.4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.2.358"},{"key":"2025121223313054000_8.3.e013775.5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7895\/ijadr.v3i1.174","article-title":"Fetal alcohol spectrum disorders must be recognized globally as a large public health problem","volume":"3","author":"Popova","year":"2014","journal-title":"Int J Alcohol Drug Res"},{"key":"2025121223313054000_8.3.e013775.6","first-page":"1","article-title":"Guidelines for identifying and referring persons with fetal alcohol syndrome. 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