{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T11:19:14Z","timestamp":1765711154640,"version":"3.48.0"},"reference-count":49,"publisher":"BMJ","issue":"8","funder":[{"name":"Department of Anesthesiology, Taipei Medical University Hospital, Taiwan"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2017,6,28]]},"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the optimal dose of succinylcholine for laryngeal mask airway (LMA) insertion and all related morbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Systematic review, meta-analysis and metaregression of randomised controlled trials (RCTs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data source and study eligibility criteria<\/jats:title>\n                    <jats:p>A comprehensive search of RCTs in the PubMed, Embase, the Cochrane Library and the ClinicalTrials.gov registry up to July 2016 and articles that evaluated the use of succinylcholine chloride for LMA insertion were included in the analyses. The relative risk (RR) and the corresponding 95% CIs were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>Succinylcholine as the coinduction agent and the doses were divided into mini (\u22640.3\u2009mg\/kg) and low (0.3\u20131.0\u2009mg\/kg) doses for dose-dependent effect analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcomes<\/jats:title>\n                    <jats:p>The primary outcome was the first-attempt LMA insertion failure rate. Secondary outcomes included all related adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data from 10 RCTs comprising 625 participants showed that succinylcholine reduced the first-attempt LMA insertion failure rate (RR, 0.22; 95%\u2009CI 0.12 to 0.43), coughing and gagging (RR, 0.26; 95%\u2009CI 0.15 to 0.45) and laryngospasm (RR, 0.14; 95%\u2009CI 0.05 to 0.39). The use of succinylcholine did not result in a significant increase of postoperative myalgia (RR, 2.58; 95%\u2009CI 0.79 to 8.44) and did not reduce the risk of postoperative sore throat (RR, 0.76; 95%\u2009CI 0.55 to 1.03). Subgroup analysis further showed that low-dose succinylcholine reduced the LMA insertion failure rate and its related coughing and gagging when compared with mini dose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of succinylcholine compared with none can facilitate LMA insertion and reduce insertion-related reflexes without significant postoperative myalgia. However, additional prospective studies with a larger sample size are required to fully evaluate the dose-dependent effect and complications of succinylcholine for LMA insertion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2016-014274","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T15:12:47Z","timestamp":1544541167000},"page":"e014274","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Optimal dose of succinylcholine for laryngeal mask airway insertion: systematic review, meta-analysis and metaregression of randomised control trials"],"prefix":"10.1136","volume":"7","author":[{"given":"Alan Hsi-Wen","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Taipei Medical University Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Cih","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chyi-Huey","family":"Bai","sequence":"additional","affiliation":[{"name":"School of Public Health, College of Nutrition and Public Health, Taipei Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Taipei Medical University Hospital, Taipei, Taiwan"},{"name":"Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"},{"name":"Graduate Institute of Humanities in Medicine, College of Humanities and Social Sciences, Taipei Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,8,4]]},"reference":[{"key":"2025121403144927000_7.8.e014274.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-4679(00)00273-0"},{"key":"2025121403144927000_7.8.e014274.2","first-page":"62","article-title":"Midazolam or mini-dose succinylcholine as co-induction agent to aid laryngeal mask airway insertion during propofol anaesthesia","volume":"4","author":"Jain","year":"2015","journal-title":"Int J Res Med"},{"key":"2025121403144927000_7.8.e014274.3","first-page":"209","article-title":"Improving the success rate of laryngeal mask airway insertion during etomidate induction by using fentanyl or succinylcholine","volume":"42","author":"Liou","year":"2004","journal-title":"Acta Anaesthesiol Taiwan"},{"key":"2025121403144927000_7.8.e014274.4","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/EJA.0000000000000195","article-title":"A complication of the laryngeal mask airway: pharyngolaryngeal rupture and pneumomediastinum","volume":"32","author":"Atalay","year":"2015","journal-title":"Eur J Anaesthesiol"},{"key":"2025121403144927000_7.8.e014274.5","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318255e6ab"},{"key":"2025121403144927000_7.8.e014274.6","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/00000542-199307000-00029","article-title":"Laryngeal mask airway and pulmonary edema","volume":"79","author":"Stiff","year":"1993","journal-title":"Anesthesiology"},{"key":"2025121403144927000_7.8.e014274.7","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199911000-00023"},{"key":"2025121403144927000_7.8.e014274.8","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/j.1365-2044.1991.tb09595.x","article-title":"Comparison of high and low doses of suxamethonium","volume":"46","author":"Stewart","year":"1991","journal-title":"Anaesthesia"},{"key":"2025121403144927000_7.8.e014274.9","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1046\/j.1365-2044.2000.055002144.x","article-title":"Succinylcholine-associated postoperative myalgia","volume":"55","author":"Wong","year":"2000","journal-title":"Anaesthesia"},{"key":"2025121403144927000_7.8.e014274.10","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200311000-00006"},{"key":"2025121403144927000_7.8.e014274.11","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200311000-00007"},{"key":"2025121403144927000_7.8.e014274.12","unstructured":"Monem A , Khan F . 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