{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:46:48Z","timestamp":1788583608739,"version":"build-2803163510"},"reference-count":45,"publisher":"BMJ","issue":"1","funder":[{"DOI":"10.13039\/501100006387","name":"Fondation Leenaards","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006387","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2016,11,25]]},"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The burden of multiple diagnoses is well documented in older people, but less is known about chronic symptoms, many of which are even not brought to medical attention. This study aimed to determine the prevalence of chronic symptoms, their relationships with disability in basic activities of daily living (BADL) and quality of life (QoL), and their public health impact.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A large cross-sectional population-based study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Community in 2 regions of French-speaking Switzerland.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Community-dwelling older adults aged 68\u2005years and older in 2011 (N=5300).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcomes<\/jats:title>\n                    <jats:p>Disability in BADL defined as difficulty or help needed with any of dressing, bathing, eating, getting in\/out of bed or an arm chair, and using the toilet. Overall QoL dichotomised as favourable (ie, excellent or very good) or unfavourable (ie, good, fair or poor). Disturbance by any of the following 14 chronic symptoms for at least 6\u2005months: joint pain, back pain, chest pain, dyspnoea, persistent cough, swollen legs, memory gaps, difficulty concentrating, difficulty making decisions, dizziness\/vertigo, skin problems, stomach\/intestine problems, urinary incontinence and impaired sexual life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Only 17.1% of participants did not report being disturbed by any of these chronic symptoms. Weighted prevalence ranged from 3.1% (chest pain) to 47.7% (joint pain). Most chronic symptoms were significantly associated with disability in BADL or unfavourable QoL, with substantial gender differences. The number of chronic symptoms was significantly associated with disability in BADL and unfavourable QoL, with gradients suggesting dose\u2013response relationships. Joint pain and back pain had the highest population attributable fractions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Chronic symptoms are highly prevalent in older people, and are associated with disability in BADL and unfavourable QoL, particularly when multiple chronic symptoms co-occur. Owing to their high public health impact, musculoskeletal chronic symptoms represent good targets for preventive interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2016-014485","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T21:31:06Z","timestamp":1484688666000},"page":"e014485","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":34,"title":["Chronic symptoms in a representative sample of community-dwelling older people: a cross-sectional study in Switzerland"],"prefix":"10.1136","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8251-8393","authenticated-orcid":false,"given":"Yves","family":"Henchoz","sequence":"first","affiliation":[{"name":"Institute of Social and Preventive Medicine, University of Lausanne Hospital Centre, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"B\u00fcla","sequence":"additional","affiliation":[{"name":"Service of Geriatric Medicine and Geriatric Rehabilitation, Lausanne University Hospital, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idris","family":"Guessous","sequence":"additional","affiliation":[{"name":"Unit of Population Epidemiology, Geneva University Hospitals, Geneva, Switzerland"},{"name":"Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Rodondi","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, University Hospital of Bern, Bern, Switzerland"},{"name":"Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Goy","sequence":"additional","affiliation":[{"name":"Pro Senectute Vaud, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Demont","sequence":"additional","affiliation":[{"name":"Pro Senectute Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Santos-Eggimann","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine, University of Lausanne Hospital Centre, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,1,17]]},"reference":[{"key":"2025120521264491000_7.1.e014485.1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-0461"},{"key":"2025120521264491000_7.1.e014485.2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt113"},{"key":"2025120521264491000_7.1.e014485.3","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-198706000-00008"},{"key":"2025120521264491000_7.1.e014485.4","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1186\/s12889-015-2034-5","article-title":"Self-reported symptoms and healthcare seeking in the general population\u2014exploring \u201cThe Symptom Iceberg\u201d","volume":"15","author":"Elnegaard","year":"2015","journal-title":"BMC Public Health"},{"key":"2025120521264491000_7.1.e014485.5","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp11X548910"},{"key":"2025120521264491000_7.1.e014485.6","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2296-12-16"},{"key":"2025120521264491000_7.1.e014485.7","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007629920752"},{"key":"2025120521264491000_7.1.e014485.8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3109\/02813439008994923","article-title":"Symptoms by age and sex. 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