{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:40:32Z","timestamp":1778665232686,"version":"3.51.4"},"reference-count":18,"publisher":"BMJ","issue":"6","funder":[{"name":"the Traditional Korean Medicine R&D program that is funded by the Ministry of Health & Welfare through the Korea Health Industry Development Institute"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2017,4,24]]},"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Primary dysmenorrhoea is menstrual pain without pelvic pathology and is the most common gynaecological condition in women. Xuefu Zhuyudecoction (XZD) or Hyeolbuchukeo-tang, a traditional herbal formula, has been used as a treatment for primary dysmenorrhoea. The purpose of this study is to assess the current published evidence regarding XZD as treatment for primary dysmenorrhoea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>The following databases will be searched from their inception until April 2017: MEDLINE (via PubMed), Allied and Complementary Medicine Database (AMED), EMBASE, The Cochrane Library, six Korean medical databases (Korean Studies Information Service System, DBPia, Oriental Medicine Advanced Searching Integrated System, Research Information Service System, Korea Med and the Korean Traditional Knowledge Portal), three Chinese medical databases (China National Knowledge Infrastructure (CNKI), Wan Fang Database and Chinese Scientific Journals Database (VIP)) and one Japanese medical database (CiNii). Randomised clinical trials (RCTs) that will be included in this systematic review comprise those that used XZD or modified XZD. The control groups in the RCTs include no treatment, placebo, conventional medication or other treatments. Trials testing XZD as an adjunct to other treatments and studies where the control group received the same treatment as the intervention group will be also included. Data extraction and risk of bias assessments will be performed by two independent reviewers. The risk of bias will be assessed with the Cochrane risk of bias tool. All statistical analyses will be conducted using Review Manager software (RevMan V.5.3.0).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This systematic review will be published in a peer-reviewed journal. The review will also be disseminated electronically and in print. The review will benefit patients and practitioners in the fields of traditional and conventional medicine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD42016050447.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2016-015056","type":"journal-article","created":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T20:20:10Z","timestamp":1497558010000},"page":"e015056","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Herbal medicine (Hyeolbuchukeo-tang or Xuefu Zhuyu decoction) for treating primary dysmenorrhoea: protocol for a systematic review of randomised controlled trials"],"prefix":"10.1136","volume":"7","author":[{"given":"Junyoung","family":"Jo","sequence":"first","affiliation":[{"name":"Department of Korean Medicine Obstetrics and Gynecology, Conmaul Hospital of Korean Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jungtae","family":"Leem","sequence":"additional","affiliation":[{"name":"Korean Medicine Clinical Trial Center, Kyung Hee University Korean Medicine Hospital, Seoul, South Korea"},{"name":"Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Moo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Korean Medicine Obstetrics and Gynecology, College of Korean Medicine, Kyung Hee University, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoung Sun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Korean Medicine Obstetrics and Gynecology, College of Korean Medicine, Kyung Hee University, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,6,15]]},"reference":[{"key":"2025121605082263000_7.6.e015056.1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000230214.26638.0c"},{"key":"2025121605082263000_7.6.e015056.2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7550.1134"},{"key":"2025121605082263000_7.6.e015056.3","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv039"},{"key":"2025121605082263000_7.6.e015056.4","first-page":"Cd001751","article-title":"Nonsteroidal anti-inflammatory drugs for dysmenorrhoea","volume":"7","author":"Marjoribanks","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"2025121605082263000_7.6.e015056.5","first-page":"Cd005288","article-title":"Chinese herbal medicine for primary dysmenorrhoea","volume":"2","author":"Zhu","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"2025121605082263000_7.6.e015056.6","first-page":"Cd007854","article-title":"Acupuncture for dysmenorrhoea","volume":"4","author":"Smith","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"2025121605082263000_7.6.e015056.7","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ctcp.2016.05.001","article-title":"TENS and heat therapy for pain relief and quality of life improvement in individuals with primary dysmenorrhea: a systematic review","volume":"24","author":"Igwea","year":"2016","journal-title":"Complement Ther Clin Pract"},{"key":"2025121605082263000_7.6.e015056.8","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/403251"},{"key":"2025121605082263000_7.6.e015056.9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/967087","article-title":"Korean studies on blood stasis: an overview","volume":"2015","author":"Park","year":"2015","journal-title":"Evid Based Complement Alternat Med"},{"key":"2025121605082263000_7.6.e015056.10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.maturitas.2015.11.013","article-title":"Herbal medicine (Danggui Shaoyao San) for treating primary dysmenorrhea: a systematic review and meta-analysis of randomized controlled trials","volume":"85","author":"Lee","year":"2016","journal-title":"Maturitas"},{"key":"2025121605082263000_7.6.e015056.11","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.maturitas.2016.01.012","article-title":"Herbal medicine (Shaofu Zhuyu decoction) for treating primary dysmenorrhea: a systematic review of randomized clinical trials","volume":"86","author":"Lee","year":"2016","journal-title":"Maturitas"},{"key":"2025121605082263000_7.6.e015056.12","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-011071","article-title":"Herbal medicine (Gyejibongneyong-hwan) for treating primary dysmenorrhoea: a protocol for a systematic review of randomised controlled trials","volume":"6","author":"Lee","year":"2016","journal-title":"BMJ Open"},{"key":"2025121605082263000_7.6.e015056.13","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00136"},{"key":"2025121605082263000_7.6.e015056.14","unstructured":"Higgins JPT , Altman DG . The Cochrane Collaboration. Chapter 8: assessing risk of bias in included studies. In: Higgins J , Green S , Eds, Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0, 2011. http:\/\/www.cochrane-handbook.org."},{"key":"2025121605082263000_7.6.e015056.15","unstructured":"Deeks JJ , Higgins JPT , Altman DG . The Cochrane Collaboration. Chapter 9: analyzing data and undertaking meta-analyses. In: Higgins J , Green S , Eds, Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0, 2011. http:\/\/www.cochrane-handbook.org."},{"key":"2025121605082263000_7.6.e015056.16","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"2025121605082263000_7.6.e015056.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.12.020"},{"key":"2025121605082263000_7.6.e015056.18","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/ptr.1905","article-title":"Common traditional Chinese medicinal herbs for dysmenorrhea","volume":"20","author":"Jia","year":"2006","journal-title":"Phytother Res"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2016-015056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T13:08:31Z","timestamp":1765890511000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2016-015056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":18,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6,15]]},"published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1136\/bmjopen-2016-015056"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2016-015056","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]}}}