{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T21:49:52Z","timestamp":1766180992093,"version":"3.48.0"},"reference-count":49,"publisher":"BMJ","issue":"7","funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2017,5,16]]},"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Circulating 25-hydroxyvitamin D (25-OHD) is associated with improved cancer prognosis in some studies, yet it may be a surrogate marker for physical activity. We investigated the associations of leisure-time physical activity (LTPA) with circulating 25-OHD levels in cancer survivors, and determined whether associations differ by indoor and outdoor activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>The US National Health and Nutrition Examination Survey (NHANES).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Cancer survivors with available data on demographic information, measures of adiposity, smoking history, self-reported LTPA and circulating 25-OHD levels in five waves of NHANES (2001\u20132010).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcomes measures<\/jats:title>\n                    <jats:p>Circulating 25-OHD levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multivariable linear regression and logistic regression models were used to evaluate the associations of self-reported LTPA with 25-OHD, adjusting for potential confounders. Due to the differences in LTPA measure, the analyses were conducted separately for 2001\u20132006 and 2007\u20132010 data. We further estimated associations by indoor and outdoor activity in the 2001\u20132006 data. There were 1530 cancer survivors (mean age=60.5 years, mean body mass index=28.6\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). The prevalent cancer sites were breast (19.3%), prostate (18.8%), cervix (10.4%) and colon (8.6%). Compared with inactive cancer survivors, being physically active was associated with higher circulating 25-OHD levels (8.07\u2009nmol\/L, 95%\u2009CI 4.63 to 11.52) for 2001\u20132006 data. In the mutually adjusted model, higher outdoor activity (5.83\u2009nmol\/L, 95%\u2009CI 1.64 to 10.01), but not indoor activity (2.93\u2009nmol\/L, 95%\u2009CI \u22121.80 to 7.66), was associated with statistically significantly higher 25-OHD levels. The interaction between indoor and outdoor activities was, however, not significant (p=0.29). The only statistically significant association seen in the 2007\u20132010 data was among obese cancer survivors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Physical activity, particularly outdoor activity, is associated with higher 25-OHD levels in cancer survivors. In view of the possible beneficial effects of vitamin D on cancer prognosis, engaging in outdoor physical activity could provide clinically meaningful increases in 25-OHD levels among cancer survivors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2017-016064","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T20:10:16Z","timestamp":1499803816000},"page":"e016064","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Leisure-time physical activity and circulating 25-hydroxyvitamin D levels in cancer survivors: a cross-sectional analysis using data from the US National Health and Nutrition Examination Survey"],"prefix":"10.1136","volume":"7","author":[{"given":"Lin","family":"Yang","sequence":"first","affiliation":[{"name":"The Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine and Siteman Cancer Center, St Louis, Missouri, USA"},{"name":"Department of Epidemiology, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adetunji T","family":"Toriola","sequence":"additional","affiliation":[{"name":"The Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine and Siteman Cancer Center, St Louis, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,7,10]]},"reference":[{"key":"2025121512090974000_7.7.e016064.1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21349"},{"key":"2025121512090974000_7.7.e016064.2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-0053"},{"key":"2025121512090974000_7.7.e016064.3","doi-asserted-by":"crossref","unstructured":"Yao S , Kwan ML , Ergas IJ , et al . 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