{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T21:38:49Z","timestamp":1769204329502,"version":"3.49.0"},"reference-count":60,"publisher":"BMJ","issue":"6","funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wellcome Trust Major Overseas Programme Core Awards for Malawi Liverpool Wellcome Programme and Oxford University Clinical Research Unit"},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2017,5,26]]},"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Invasive infections caused by\n                      <jats:italic>Salmonella enterica<\/jats:italic>\n                      serovar Typhi and Paratyphi A are estimated to account for 12\u201327\u2009million febrile illness episodes worldwide annually. Determining the true burden of typhoidal\n                      <jats:italic>Salmonellae<\/jats:italic>\n                      infections is hindered by lack of population-based studies and adequate laboratory diagnostics.\n                    <\/jats:p>\n                    <jats:p>\n                      The Strategic Typhoid alliance across Africa and Asia study takes a systematic approach to measuring the age-stratified burden of clinical and subclinical disease caused by typhoidal\n                      <jats:italic>Salmonellae<\/jats:italic>\n                      infections at three high-incidence urban sites in Africa and Asia. We aim to explore the natural history of\n                      <jats:italic>Salmonella<\/jats:italic>\n                      transmission in endemic settings, addressing key uncertainties relating to the epidemiology of enteric fever identified through mathematical models, and enabling optimisation of vaccine strategies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\/design<\/jats:title>\n                    <jats:p>\n                      Using census-defined denominator populations of \u2265100\u2009000 individuals at sites in Malawi, Bangladesh and Nepal, the primary outcome is to characterise the burden of enteric fever in these populations over a 24-month period. During passive surveillance, clinical and household data, and laboratory samples will be collected from febrile individuals. In parallel, healthcare utilisation and water, sanitation and hygiene surveys will be performed to characterise healthcare-seeking behaviour and assess potential routes of transmission. The rates of both undiagnosed and subclinical exposure to typhoidal\n                      <jats:italic>Salmonellae<\/jats:italic>\n                      (seroincidence), identification of chronic carriage and population seroprevalence of typhoid infection will be assessed through age-stratified serosurveys performed at each site. Secondary attack rates will be estimated among household contacts of acute enteric fever cases and possible chronic carriers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This protocol has been ethically approved by the Oxford Tropical Research Ethics Committee, the icddr,b Institutional Review Board, the Malawian National Health Sciences Research Committee and College of Medicine Research Ethics Committee and Nepal Health Research Council. The study is being conducted in accordance with the principles of the Declaration of Helsinki and Good Clinical Practice. Informed consent was obtained before study enrolment. Results will be submitted to international peer-reviewed journals and presented at international conferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>ISRCTN 12131979.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics references<\/jats:title>\n                    <jats:p>Oxford (Oxford Tropical Research Ethics Committee 39-15).<\/jats:p>\n                    <jats:p>Bangladesh (icddr,b Institutional Review Board PR-15119).<\/jats:p>\n                    <jats:p>Malawi (National Health Sciences Research Committee 15\/5\/1599).<\/jats:p>\n                    <jats:p>Nepal (Nepal Health Research Council 306\/2015).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2017-016283","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T20:10:56Z","timestamp":1499112656000},"page":"e016283","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":70,"title":["The STRATAA study protocol: a programme to assess the burden of enteric fever in Bangladesh, Malawi and Nepal using prospective population census, passive surveillance, serological studies and healthcare utilisation surveys"],"prefix":"10.1136","volume":"7","author":[{"given":"Thomas C","family":"Darton","sequence":"first","affiliation":[{"name":"The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam"},{"name":"Department of Paediatrics, Oxford Vaccine Group,University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, UK"},{"name":"Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9183-5174","authenticated-orcid":false,"given":"James E","family":"Meiring","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Oxford Vaccine Group,University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Tonks","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Oxford Vaccine Group,University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md Arifuzzaman","family":"Khan","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Diseases Research, Dhaka, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhana","family":"Khanam","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Diseases Research, Dhaka, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mila","family":"Shakya","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit, Patan Academy of Health Sciences, Kathmandu, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deus","family":"Thindwa","sequence":"additional","affiliation":[{"name":"Malawi Liverpool Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Blantyre, Malawi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Baker","sequence":"additional","affiliation":[{"name":"The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam"},{"name":"Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK"},{"name":"The Wellcome Trust Sanger Institute, Cambridgeshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Buddha","family":"Basnyat","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit, Patan Academy of Health Sciences, Kathmandu, Nepal"},{"name":"Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D","family":"Clemens","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Diseases Research, Dhaka, Bangladesh"},{"name":"UCLA Fielding School of Public Health, Los Angeles, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon","family":"Dougan","sequence":"additional","affiliation":[{"name":"The Wellcome Trust Sanger Institute, Cambridgeshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Dolecek","sequence":"additional","affiliation":[{"name":"Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK"},{"name":"Mahidol-Oxford Tropical Medicine Research Unit,Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah J","family":"Dunstan","sequence":"additional","affiliation":[{"name":"The Peter Doherty Institute for Infection and Immunity,The University of Melbourne, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melita A","family":"Gordon","sequence":"additional","affiliation":[{"name":"Malawi Liverpool Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Blantyre, Malawi"},{"name":"Institute of Infection and Global Health,University of Liverpool, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S","family":"Heyderman","sequence":"additional","affiliation":[{"name":"Malawi Liverpool Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Blantyre, Malawi"},{"name":"Division of Infection and Immunity, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn E","family":"Holt","sequence":"additional","affiliation":[{"name":"Centre for Systems Genomics,University of Melbourne, Victoria, Australia"},{"name":"Department of Biochemistry and Molecular Biology, University of Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia E","family":"Pitzer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, Connecticut, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firdausi","family":"Qadri","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Diseases Research, Dhaka, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Zaman","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Diseases Research, Dhaka, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J","family":"Pollard","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Oxford Vaccine Group,University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,7,2]]},"reference":[{"key":"2025121411515617000_7.6.e016283.1","doi-asserted-by":"publisher","DOI":"10.1086\/649541"},{"key":"2025121411515617000_7.6.e016283.2","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.02.010401"},{"key":"2025121411515617000_7.6.e016283.3","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(14)70301-8"},{"key":"2025121411515617000_7.6.e016283.4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002925"},{"key":"2025121411515617000_7.6.e016283.5","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000021"},{"key":"2025121411515617000_7.6.e016283.6","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3281"},{"key":"2025121411515617000_7.6.e016283.7","unstructured":"WHO. WHO\/IVB\/12.02. BMJ Publishing Group. 2013."},{"key":"2025121411515617000_7.6.e016283.8","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2013.845529"},{"key":"2025121411515617000_7.6.e016283.9","doi-asserted-by":"publisher","DOI":"10.1084\/jem.166.5.1510"},{"key":"2025121411515617000_7.6.e016283.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104263441701"},{"key":"2025121411515617000_7.6.e016283.11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074097","article-title":"Stochastic simulation of endemic Salmonella enterica serovar Typhi: the importance of long lasting immunity and the carrier state","volume":"8","author":"Saul","year":"2013","journal-title":"PLoS One"},{"key":"2025121411515617000_7.6.e016283.12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002642"},{"key":"2025121411515617000_7.6.e016283.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.04.013"},{"key":"2025121411515617000_7.6.e016283.14","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1017\/S0950268807009338","article-title":"Part I. Analysis of data gaps pertaining to Salmonella enterica serotype Typhi infections in low and medium human development index countries, 1984-2005","volume":"136","author":"Crump","year":"2008","journal-title":"Epidemiol Infect"},{"key":"2025121411515617000_7.6.e016283.15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001923"},{"key":"2025121411515617000_7.6.e016283.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61689-4"},{"key":"2025121411515617000_7.6.e016283.17","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1001\/jamapediatrics.2015.4276","article-title":"Global and National Burden of Diseases and Injuries among Children and Adolescents between 1990 and 2013","volume":"170","author":"Kyu","year":"2016","journal-title":"JAMA Pediatr"},{"key":"2025121411515617000_7.6.e016283.18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12941-016-0147-z","article-title":"What proportion of Salmonella Typhi cases are detected by blood culture? A systematic literature review","volume":"15","author":"Mogasale","year":"2016","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"2025121411515617000_7.6.e016283.19","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12879-016-1351-3","article-title":"Revisiting typhoid fever surveillance in low and middle income countries: lessons from systematic literature review of population-based longitudinal studies","volume":"16","author":"Mogasale","year":"2016","journal-title":"BMC Infect Dis"},{"key":"2025121411515617000_7.6.e016283.20","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.76.892.80"},{"key":"2025121411515617000_7.6.e016283.21","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-45"},{"key":"2025121411515617000_7.6.e016283.22","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu078"},{"key":"2025121411515617000_7.6.e016283.23","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.11.087627"},{"key":"2025121411515617000_7.6.e016283.24","doi-asserted-by":"publisher","DOI":"10.1586\/eri.11.47"},{"key":"2025121411515617000_7.6.e016283.25","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.03100","article-title":"Salmonella Typhi and Salmonella Paratyphi A elaborate distinct systemic metabolite signatures during enteric fever","volume":"3","author":"N\u00e4sstr\u00f6m","year":"2014","journal-title":"Elife"},{"key":"2025121411515617000_7.6.e016283.26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912386106"},{"key":"2025121411515617000_7.6.e016283.27","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151025"},{"key":"2025121411515617000_7.6.e016283.28","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/146.6.724"},{"key":"2025121411515617000_7.6.e016283.29","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00245-09"},{"key":"2025121411515617000_7.6.e016283.30","doi-asserted-by":"crossref","first-page":"795","DOI":"10.4269\/ajtmh.1978.27.795","article-title":"Diagnostic value of the Widal test in areas endemic for typhoid fever","volume":"27","author":"Levine","year":"1978","journal-title":"Am J Trop Med Hyg"},{"key":"2025121411515617000_7.6.e016283.31","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)93507-5"},{"key":"2025121411515617000_7.6.e016283.32","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1128\/jcm.12.1.22-26.1980","article-title":"Evaluation of a new assay for Vi antibody in chronic carriers of Salmonella typhi","volume":"12","author":"Nolan","year":"1980","journal-title":"J Clin Microbiol"},{"key":"2025121411515617000_7.6.e016283.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2005.06.005"},{"key":"2025121411515617000_7.6.e016283.34","doi-asserted-by":"publisher","DOI":"10.1038\/srep01043"},{"key":"2025121411515617000_7.6.e016283.35","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3143"},{"key":"2025121411515617000_7.6.e016283.36","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-007-0372-9"},{"key":"2025121411515617000_7.6.e016283.37","doi-asserted-by":"publisher","DOI":"10.1038\/ng.195"},{"key":"2025121411515617000_7.6.e016283.38","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.110008"},{"key":"2025121411515617000_7.6.e016283.39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047342","article-title":"The microbiological and clinical characteristics of invasive salmonella in gallbladders from cholecystectomy patients in kathmandu, Nepal","volume":"7","author":"Dongol","year":"2012","journal-title":"PLoS One"},{"key":"2025121411515617000_7.6.e016283.40","unstructured":"WHO. WHO | typhoid vaccines position paper. BMJ Publishing Group. 2008."},{"key":"2025121411515617000_7.6.e016283.41","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00532-10"},{"key":"2025121411515617000_7.6.e016283.42","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ295"},{"key":"2025121411515617000_7.6.e016283.43","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1080\/21645515.2015.1117715","article-title":"Efficacy and safety of vi-tetanus toxoid conjugated typhoid vaccine (PedaTyph)","volume":"12","author":"Mitra","year":"2016","journal-title":"Hum Vaccin Immunother"},{"key":"2025121411515617000_7.6.e016283.44","doi-asserted-by":"crossref","first-page":"e0004926","DOI":"10.1371\/journal.pntd.0004926","article-title":"Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a","volume":"10","author":"Darton","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"2025121411515617000_7.6.e016283.45","doi-asserted-by":"crossref","first-page":"20407","DOI":"10.7189\/jogh.05.020407","article-title":"Systematic review of the global epidemiology, clinical and laboratory profile of enteric fever","volume":"5","author":"Azmatullah","year":"2015","journal-title":"J Glob Health"},{"key":"2025121411515617000_7.6.e016283.46","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ691"},{"key":"2025121411515617000_7.6.e016283.47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003748"},{"key":"2025121411515617000_7.6.e016283.48","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200105000-00010"},{"key":"2025121411515617000_7.6.e016283.49","doi-asserted-by":"publisher","DOI":"10.3201\/eid1102.040422"},{"key":"2025121411515617000_7.6.e016283.50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003619"},{"key":"2025121411515617000_7.6.e016283.51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001102"},{"key":"2025121411515617000_7.6.e016283.52","doi-asserted-by":"publisher","DOI":"10.1086\/529146"},{"key":"2025121411515617000_7.6.e016283.53","doi-asserted-by":"crossref","first-page":"S251","DOI":"10.1093\/cid\/civ710","article-title":"Mathematical Modeling to Assess the Drivers of the Recent Emergence of Typhoid Fever in Blantyre, Malawi","volume":"61 Suppl 4","author":"Pitzer","year":"2015","journal-title":"Clin Infect Dis"},{"key":"2025121411515617000_7.6.e016283.54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013988","article-title":"The burden and characteristics of enteric fever at a healthcare facility in a densely populated area of Kathmandu","volume":"5","author":"Karkey","year":"2010","journal-title":"PLoS One"},{"key":"2025121411515617000_7.6.e016283.55","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.14003","article-title":"A novel ciprofloxacin-resistant subclade of H58 Salmonella Typhi is associated with fluoroquinolone treatment failure","volume":"5","author":"Pham Thanh","year":"2016","journal-title":"Elife"},{"key":"2025121411515617000_7.6.e016283.56","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1128\/iai.52.1.209-212.1986","article-title":"Antibodies to porin antigens of Salmonella typhi induced during typhoid infection in humans","volume":"52","author":"Calder\u00f3n","year":"1986","journal-title":"Infect Immun"},{"key":"2025121411515617000_7.6.e016283.57","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0140-6736(81)92033-X","article-title":"Vi serology in the detection of typhoid carriers","volume":"1","author":"Nolan","year":"1981","journal-title":"Lancet"},{"key":"2025121411515617000_7.6.e016283.58","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02439.x"},{"key":"2025121411515617000_7.6.e016283.59","unstructured":"ODK. Open Data kit. https:\/\/opendatakit.org\/"},{"key":"2025121411515617000_7.6.e016283.60","unstructured":"OpenClinica - Electronic data capture for clinical research. https:\/\/www.openclinica.com\/"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2017-016283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T19:52:04Z","timestamp":1765741924000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2017-016283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":60,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,7,2]]},"published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1136\/bmjopen-2017-016283"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2017-016283","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]}}}