{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:10:26Z","timestamp":1765699826299,"version":"3.48.0"},"reference-count":42,"publisher":"BMJ","issue":"9","funder":[{"name":"Capital Development Research Fund Project"},{"name":"Clinical Medicine Development of Special Funding Support from Beijing Municipal Administration of Hospitals"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2017,6,19]]},"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Recent studies have shown that deep anaesthesia is associated with poor outcomes. However, no randomised controlled trials have been conducted to test the causality in patients undergoing brain tumour resection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>DEPTH is a multicenter, randomised, parallel-group, blind trial. The depth of general anaesthesia will be monitored using the bispectral index (BIS). Patients elected for supratentorial tumour resection will be randomly allocated to the deep or the light anaesthesia group in which the target BIS value is 35 or 50, respectively. BIS will be maintained at the target value for more than 90% of the total anaesthesia period. The primary outcome is the disability-free survival rate at postoperative 30 days and 1\u2009year. The secondary outcomes are the mortality and morbidity within 30 days after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics approval and dissemination<\/jats:title>\n                    <jats:p>Ethical approval has been granted by the Medical Ethics Committee of Beijing Tiantan Hospital, Capital Medicine University. The reference number is KY2016-059-02. The results of this study will be disseminated through presentations at scientific conferences and publication in scientific journals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>NCT03033693.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2017-016521","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T20:10:14Z","timestamp":1505247014000},"page":"e016521","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of anesthesia\n                    <i>de<\/i>\n                    pth on\n                    <i>p<\/i>\n                    ostoperative clinical ou\n                    <i>t<\/i>\n                    come in patients with supratentorial tumor (DEPTH): study protocol for a randomized controlled trial"],"prefix":"10.1136","volume":"7","author":[{"given":"Qianyu","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuming","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruquan","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,9,11]]},"reference":[{"key":"2025121400065815000_7.9.e016521.1","first-page":"2578","article-title":"Prevalence estimates for primary brain tumors in China: a multi-center cross-sectional study","volume":"124","author":"Jiang","year":"2011","journal-title":"Chin Med J"},{"key":"2025121400065815000_7.9.e016521.2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s11060-015-2046-0","article-title":"Clinical outcome of gliosarcoma compared with glioblastoma multiforme: a clinical study in Chinese patients","volume":"127","author":"Zhang","year":"2016","journal-title":"J Neurooncol"},{"key":"2025121400065815000_7.9.e016521.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.01.010"},{"key":"2025121400065815000_7.9.e016521.4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1227\/NEU.0000000000000349","article-title":"Greater extent of resection improves ganglioglioma recurrence-free survival in children: a volumetric analysis","volume":"75","author":"Haydon","year":"2014","journal-title":"Neurosurgery"},{"key":"2025121400065815000_7.9.e016521.5","first-page":"325","article-title":"Prospective, randomized study to assess the role of dexmedetomidine in patients with supratentorial tumors undergoing craniotomy under general anaesthesia","volume":"21","author":"Soliman","year":"2011","journal-title":"Middle East J Anaesthesiol"},{"key":"2025121400065815000_7.9.e016521.6","doi-asserted-by":"crossref","first-page":"633","DOI":"10.3171\/2010.5.JNS1041","article-title":"A retrospective cohort-matched comparison of conscious sedation versus general anesthesia for supratentorial glioma resection\u00a0","volume":"114","author":"Peruzzi","year":"2011","journal-title":"J Neurosurg"},{"key":"2025121400065815000_7.9.e016521.7","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/978-3-540-74806-9_19","article-title":"Defining depth of anesthesia","volume":"182","author":"Shafer","year":"2008","journal-title":"Handb Exp Pharmacol"},{"key":"2025121400065815000_7.9.e016521.8","doi-asserted-by":"crossref","unstructured":"Liu Q , Chen YF , Fan SZ , et al . 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