{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:01:33Z","timestamp":1790370093491,"version":"4.1.0"},"reference-count":33,"publisher":"BMJ","issue":"8","funder":[{"DOI":"10.13039\/100006093","name":"Patient-Centered Outcomes Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2017,6,12]]},"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Limited evidence for the optimal venous thromboembolism (VTE) prophylaxis regimen in orthopaedic trauma leads to variability in regimens. We sought to delineate patient preferences towards cost, complication profile, and administration route (oral tablet vs. subcutaneous injection).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Discrete choice experiment (DCE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Level 1 trauma center in Baltimore, USA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>232 adult trauma patients (mean age 47.9 years) with pelvic or acetabular fractures or operative extremity fractures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>Relative preferences and trade-off estimates for a 1% reduction in complications were estimated using multinomial logit modelling. Interaction terms were added to the model to assess heterogeneity in preferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients preferred oral tablets over subcutaneous injections (marginal utility, 0.16; 95% CI: 0.11 - 0.21,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001). Preferences changed in favor of subcutaneous injections with an absolute risk reduction of 6.98% in bleeding, 4.53% in wound complications requiring reoperation, 1.27% in VTE, and 0.07% in death from pulmonary embolism (PE). Patient characteristics (sex, race, type of injury, time since injury) affected patient preferences (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients preferred oral prophylaxis and were most concerned about risk of death from PE. Furthermore, the findings estimated the trade-offs acceptable to patients and heterogeneity in preferences for VTE prophylaxis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2017-016676","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T20:25:24Z","timestamp":1502483124000},"page":"e016676","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":41,"title":["Patient preferences for venous thromboembolism prophylaxis after injury: a discrete choice experiment"],"prefix":"10.1136","volume":"7","author":[{"given":"Bryce E","family":"Haac","sequence":"first","affiliation":[{"name":"School of Medicine, University of Maryland, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan N","family":"O'Hara","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Maryland, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Daniel","family":"Mullins","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Maryland, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah M","family":"Stein","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Maryland, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore T","family":"Manson","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Maryland, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"Johal","sequence":"additional","affiliation":[{"name":"Department of Surgery, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renan","family":"Castillo","sequence":"additional","affiliation":[{"name":"Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert V","family":"O'Toole","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Maryland, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9111-9239","authenticated-orcid":false,"given":"Gerald P","family":"Slobogean","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Maryland, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,8,11]]},"reference":[{"key":"2025121410351288000_7.8.e016676.1","doi-asserted-by":"publisher","DOI":"10.1177\/088506668800300205"},{"key":"2025121410351288000_7.8.e016676.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199412153312401"},{"key":"2025121410351288000_7.8.e016676.3","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199006000-00018"},{"key":"2025121410351288000_7.8.e016676.4","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18004821103"},{"key":"2025121410351288000_7.8.e016676.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)81272-3"},{"key":"2025121410351288000_7.8.e016676.6","doi-asserted-by":"publisher","DOI":"10.1097\/00005131-199605000-00002"},{"key":"2025121410351288000_7.8.e016676.7","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2001.114558"},{"key":"2025121410351288000_7.8.e016676.8","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-200109000-00015"},{"key":"2025121410351288000_7.8.e016676.9","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.D.02932"},{"key":"2025121410351288000_7.8.e016676.10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2404"},{"key":"2025121410351288000_7.8.e016676.11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c95"},{"key":"2025121410351288000_7.8.e016676.12","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-201112000-00007"},{"key":"2025121410351288000_7.8.e016676.13","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-11-201306040-00004"},{"key":"2025121410351288000_7.8.e016676.14","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.surge.2015.05.001","article-title":"Aspirin in the primary prophylaxis of venous thromboembolism in surgical patients","volume":"13","author":"Sahebally","year":"2015","journal-title":"Surgeon"},{"key":"2025121410351288000_7.8.e016676.15","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/jhm.2224","article-title":"Aspirin versus anticoagulation for prevention of venous thromboembolism major lower extremity orthopedic surgery: a systematic review and meta-analysis","volume":"9","author":"Drescher","year":"2014","journal-title":"J Hosp Med"},{"key":"2025121410351288000_7.8.e016676.16","first-page":"CD008303","article-title":"Thromboprophylaxis for trauma patients","volume":"3","author":"Barrera","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"2025121410351288000_7.8.e016676.17","doi-asserted-by":"crossref","first-page":"e355","DOI":"10.1097\/BOT.0000000000000387","article-title":"Venous thromboembolism prophylaxis in orthopaedic trauma patients: a survey of OTA member practice patterns and OTA expert panel recommendations","volume":"29","author":"Sagi","year":"2015","journal-title":"J Orthop Trauma"},{"issue":"2 Suppl","key":"2025121410351288000_7.8.e016676.18","first-page":"e1S","article-title":"Patient values and preferences in decision making for antithrombotic therapy: a systematic review: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines","volume":"141","author":"MacLean","year":"2012","journal-title":"Chestchest"},{"key":"2025121410351288000_7.8.e016676.19","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.4.436"},{"key":"2025121410351288000_7.8.e016676.20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0066311","article-title":"Patterns of non-administration of ordered doses of venous thromboembolism prophylaxis: implications for novel intervention strategies","volume":"8","author":"Shermock","year":"2013","journal-title":"PLoS One"},{"key":"2025121410351288000_7.8.e016676.21","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1001\/jamasurg.2015.1340","article-title":"Preventability of hospital-acquired venous thromboembolism","volume":"150","author":"Haut","year":"2015","journal-title":"JAMA Surg"},{"key":"2025121410351288000_7.8.e016676.22","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1001\/jamasurg.2013.3963","article-title":"Correlation of missed doses of enoxaparin with increased incidence of deep vein thrombosis in trauma and general surgery patients","volume":"149","author":"Louis","year":"2014","journal-title":"JAMA Surg"},{"key":"2025121410351288000_7.8.e016676.23","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/jhm.2282","article-title":"Patient preferences regarding pharmacologic venous thromboembolism prophylaxis","volume":"10","author":"Wong","year":"2015","journal-title":"J Hosp Med"},{"key":"2025121410351288000_7.8.e016676.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2010.11.013"},{"key":"2025121410351288000_7.8.e016676.25","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jval.2014.12.007","article-title":"Public preferences for prioritizing preventive and curative health care interventions: a discrete choice experiment","volume":"18","author":"Luyten","year":"2015","journal-title":"Value Health"},{"key":"2025121410351288000_7.8.e016676.26","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7248.1530"},{"key":"2025121410351288000_7.8.e016676.27","doi-asserted-by":"publisher","DOI":"10.1509\/jmkr.42.2.210.62285"},{"key":"2025121410351288000_7.8.e016676.28","unstructured":"Orme B . Sample size issues for conjoint analysis studies. Sequim: Sawtooth Software Technical Paper, 1998."},{"key":"2025121410351288000_7.8.e016676.29","doi-asserted-by":"publisher","DOI":"10.1086\/296093"},{"key":"2025121410351288000_7.8.e016676.30","doi-asserted-by":"publisher","DOI":"10.1016\/S1755-5345(13)70014-9"},{"key":"2025121410351288000_7.8.e016676.31","doi-asserted-by":"crossref","first-page":"269","DOI":"10.2147\/TCRM.S1458","article-title":"Factors affecting therapeutic compliance: a review from the patient's perspective","volume":"4","author":"Jin","year":"2008","journal-title":"Ther Clin Risk Manag"},{"key":"2025121410351288000_7.8.e016676.32","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2217\/cer-2015-0007","article-title":"Improving the relevance and consistency of outcomes in comparative effectiveness research","volume":"5","author":"Tunis","year":"2016","journal-title":"J Comp Eff Res"},{"key":"2025121410351288000_7.8.e016676.33","first-page":"154","article-title":"Clinical comparative effectiveness research through the lens of healthcare decision makers","volume":"15","author":"Price-Haywood","year":"2015","journal-title":"Ochsner J"}],"updated-by":[{"DOI":"10.1136\/bmjopen-2017-016676corr1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T00:00:00Z","timestamp":1513900800000}}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2017-016676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T18:35:19Z","timestamp":1765737319000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2017-016676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":33,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8,11]]},"published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1136\/bmjopen-2017-016676"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2017-016676","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8]]}}}