{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:32:13Z","timestamp":1792481533210,"version":"4.5.0"},"reference-count":15,"publisher":"BMJ","issue":"7","funder":[{"DOI":"10.13039\/501100006736","name":"Universitetssjukhuset \u00c3\u2013rebro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006736","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2017,5,30]]},"published-print":{"date-parts":[[2017,7]]},"abstract":"\n Objective<\/jats:title>\n To study the impact of occupational silica exposure on the incidence rates of sarcoidosis and rheumatoid arthritis (RA) in a cohort of exposed workers in Swedish iron foundries.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n The prevalence of sarcoidosis and RA in a cohort of silica exposed workers was compared with the prevalence in the general Swedish population in this register study. A mixed model was used to calculate silica exposure, and individual silica exposures were used to compute dose responses.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Personnel records from 10 iron foundries were used to identify workers whose employment began before 2005 which was then linked to the national non-primary outpatient visits register.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n The final cohort consisted of 2187 silica-exposed male workers who had been employed for at least 1\u2009year and were still alive without having emigrated when the follow-up study began. The cohort\u2019s employment period covers 23 807 person-years at risk.<\/jats:p>\n <\/jats:sec>\n \n Main outcome<\/jats:title>\n The presented results indicate that moderate to high levels of silica exposure increase risks for sarcoidosis and seropositive RA.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Mean levels of airborne silica dust in the foundries decreased significantly between the 1970s and 2000s. Incidence rates of sarcoidosis (3.94; 95%\u2009CI 1.07 to 10.08) and seropositive RA (2.59; 95%\u2009CI 1.24 to 4.76) were significantly higher among highly exposed individuals.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Our results reveal increased risks for sarcoidosis and seropositive RA among individuals with high exposure to silica dust (>0.048\u2009mg\/m\n 3<\/jats:sup>\n ) compared with non-exposed and less-exposed groups.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bmjopen-2017-016839","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T20:40:28Z","timestamp":1500583228000},"page":"e016839","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":88,"title":["Risk of sarcoidosis and seropositive rheumatoid arthritis from occupational silica exposure in Swedish iron foundries: a retrospective cohort study"],"prefix":"10.1136","volume":"7","author":[{"given":"Per","family":"Vihlborg","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health, Department of Occupational and Environmental Medicine, \u00d6rebro University, \u00d6rebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ing-Liss","family":"Bryngelsson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, Department of Occupational and Environmental Medicine, \u00d6rebro University, \u00d6rebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Andersson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, Department of Occupational and Environmental Medicine, \u00d6rebro University, \u00d6rebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4928-617X","authenticated-orcid":false,"given":"P\u00e5l","family":"Graff","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, Department of Occupational and Environmental Medicine, \u00d6rebro University, \u00d6rebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,7,20]]},"reference":[{"key":"2025121422430139000_7.7.e016839.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60680-7"},{"key":"2025121422430139000_7.7.e016839.2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00477-2016"},{"key":"2025121422430139000_7.7.e016839.3","unstructured":"SwedishRespiratorySociety. 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Medical Assessment in the Workplace."},{"key":"2025121422430139000_7.7.e016839.12","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.114694"},{"key":"2025121422430139000_7.7.e016839.13","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu195"},{"key":"2025121422430139000_7.7.e016839.14","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-012-0782-4"},{"key":"2025121422430139000_7.7.e016839.15","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1080\/15459624.2011.645397","article-title":"Exposure assessment and modeling of quartz in swedish iron foundries for a nested case-control study on lung Cancer","volume":"9","author":"Andersson","year":"2012","journal-title":"J Occup Environ Hyg"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2017-016839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T06:43:11Z","timestamp":1765780991000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2017-016839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":15,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7,20]]},"published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1136\/bmjopen-2017-016839"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2017-016839","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7]]}}}