{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T17:46:37Z","timestamp":1788198397189,"version":"build-2803163510"},"reference-count":35,"publisher":"BMJ","issue":"2","funder":[{"name":"six talent peaks project"},{"name":"Medical Science and technology development Foundation, Nanjing Department of Health"},{"name":"Key Project of Nanjing Science and Technology Development Foundation"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,1,24]]},"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The study sought to compare angiographic and clinical outcomes of new-generation drug-eluting stents (DES) versus drug-coated balloon (DCB) in patients with coronary in-stent restenosis (ISR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Meta-analysis using data from randomised trial found by searches on PubMed, the Cochrane Library, ClinicalTrials.gov and websites of major cardiovascular congresses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Only randomised trials comparing DES with DCB were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Patients with ISR in the included trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>New-generation DES versus DCB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcomes<\/jats:title>\n                    <jats:p>The angiographic and clinical outcomes including cardiac death, all-cause death, myocardial infarction, target lesion revascularisation (TLR), target vessel revascularisation (TVR), major adverse cardiac events (MACE) and stent thrombosis were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five trials including 913 patients were eligible and included. Pooled analysis in angiographic results identified that new-generation DES were associated with higher acute luminal gain (\u22120.31\u2009mm, 95%\u2009CI \u22120.42 to \u22120.20, P&lt;0.001) and lower per cent diameter stenosis (risk ratio (RR): 0.28, 95%\u2009CI 0.02 to 0.55, P=0.04). DES significantly reduced the risk of TLR (RR: 1.96, 95%\u2009CI 1.17 to 3.28, P=0.01) compared with DCB; however, there was no statistical differences for MACE (RR: 1.21, 95%\u2009CI 0.67 to 2.17, P=0.53), myocardial infarction (RR: 1.16, 95%\u2009CI 0.55 to 2.48, P=0.69) and cardiac death (RR: 1.80, 95%\u2009CI 0.60 to 5.39, P=0.29).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Interventions with new-generation DES appear to be associated with significant reduction in per cent diameter stenosis and TLR at short-term follow-up, but had similar MACE, myocardial infarction and cardiac death for patients with coronary ISR compared with DCB. Appropriately powered studies with longer term follow-up are warranted to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2017-017231","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T10:32:30Z","timestamp":1519381950000},"page":"e017231","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Comparison of new-generation drug-eluting stents versus drug-coated balloon for in-stent restenosis: a meta-analysis of randomised controlled trials"],"prefix":"10.1136","volume":"8","clinical-trial-number":[{"clinical-trial-number":"nct02474485","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Jin-Zan","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Cardiology, Nanjing Medical University, Nanjing, 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