{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T10:49:52Z","timestamp":1765882192197,"version":"3.48.0"},"reference-count":34,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2017,8,24]]},"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The association between tuberculosis (TB), diabetes mellitus (DM) and vitamin D status is poorly characterised. We therefore: (1) determined vitamin D status in patients with TB in relation to whether they had normal fasting blood glucose (FBG), pre-DM or DM and (2) assessed whether baseline characteristics in patients with TB, including their DM status, were associated with vitamin D deficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In patients with TB consecutively attending six clinics or hospitals in China, we measured 25-hydroxycholecalciferol (25-(OH)D\n                      <jats:sub>3<\/jats:sub>\n                      ) at the time of registration using electrochemiluminescence in a COBASE 601 Roche analyser by chemiluminescence immunoassay. Data analysis was performed using the \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      test, ORs and multivariate logistic regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 306 eligible patients with TB, including 96 with smear positive pulmonary TB, 187 with smear negative pulmonary TB and 23 with extrapulmonary TB. Of these, 95 (31%) had normal blood glucose, 83 (27%) had pre-DM and 128 (42%) had DM. Median serum vitamin D levels were 16.1\u2009ng\/mL in patients with TB with normal FBG, 12.6\u2009ng\/mL in patients with TB with pre-DM and 12.1\u2009ng\/mL in patients with TB with DM (p&lt;0.001). The study highlighted certain baseline characteristics associated with vitamin D deficiency (25-(OH)D\n                      <jats:sub>3<\/jats:sub>\n                      &lt;20\u2009ng\/mL). After adjusting for confounders, serum vitamin D deficiency was significantly more common in patients being registered in the cold season (November to April) (p=0.006) and in those with DM (p=0.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vitamin D levels are lower in patients with TB with pre-DM and DM and are also affected by certain baseline characteristics that include being registered in the cold season and having DM. TB programmes need to pay more attention to vitamin D status in their patients, especially if there is coexisting pre-DM or DM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2017-017557","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T20:10:22Z","timestamp":1506456622000},"page":"e017557","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Vitamin D status in tuberculosis patients with diabetes, prediabetes and normal blood glucose in China: a cross-sectional study"],"prefix":"10.1136","volume":"7","author":[{"given":"Xin","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Beijing Hospital, National Center of Gerontology, Beijing, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanli","family":"Yuan","sequence":"additional","affiliation":[{"name":"Director Office, Jilin Provincial Academy of Tuberculosis Control and Prevention, Changchun, Jilin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of TB and HIV, International Union Against Tuberculosis and Lung Disease, Paris, Paris, France"},{"name":"The Union China Office, International Union Against Tuberculosis and Lung Disease, Beijing, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiejuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Director Office, Jilin Provincial Academy of Tuberculosis Control and Prevention, Changchun, Jilin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Ma","sequence":"additional","affiliation":[{"name":"Director Office, Jilin Provincial Academy of Tuberculosis Control and Prevention, Changchun, Jilin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanli","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Beijing Chest Hospital, Capital Medical University, Beijing, Beijing, China"},{"name":"Department of Epidemiology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunlong","family":"Bai","sequence":"additional","affiliation":[{"name":"Director Office, Jilin Provincial Academy of Tuberculosis Control and Prevention, Changchun, Jilin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunlong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Tuberculosis, Meihekou City Tuberculosis Institute, Meihekou, Jilin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongshan","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Tuberculosis, Dongfeng County Tuberculosis Institute, Dongfeng, Jilin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riitta A","family":"Dlodlo","sequence":"additional","affiliation":[{"name":"Department of TB and HIV, International Union Against Tuberculosis and Lung Disease, Paris, Paris, France"},{"name":"Department of TB and HIV, International Union Against Tuberculosis and Lung Diseases, Bulawayo, Bulawayo, Zimbabwe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony D","family":"Harries","sequence":"additional","affiliation":[{"name":"Department of TB and HIV, International Union Against Tuberculosis and Lung Disease, Paris, Paris, France"},{"name":"Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,9,25]]},"reference":[{"key":"2025121602444592000_7.9.e017557.1","unstructured":"World Health Organization. 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