{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:32:16Z","timestamp":1789691536393,"version":"4.0.1"},"reference-count":34,"publisher":"BMJ","issue":"11","funder":[{"DOI":"10.13039\/501100000659","name":"Research Trainees Coordinating Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2017,9,15]]},"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The Prediciting factors for response to treatment in carpal tunnel syndrome (PALMS) study is designed to identify prognostic factors for outcome from corticosteroid injection and surgical decompression for carpal tunnel syndrome (CTS) and predictors of cost over 2 years. The aim of this paper is to explore the cross-sectional association of baseline patient-reported and clinical severity with anxiety, depression, health-related quality of life and costs of CTS in patients referred to secondary care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective, multicentre cohort study initiated in 2013. We collected baseline data on patient-reported symptom severity (CTS-6), psychological status (Hospital Anxiety and Depression Scale), hand function (Michigan Hand Questionnaire) comorbidities, EQ-5D-3L (3-level version of EuroQol-5 dimension) and sociodemographic variables. Nerve conduction tests classified patients into five severity grades (mild to very severe). Data were analysed using a general linear model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>753 patients with CTS provided complete baseline data. Multivariable linear regression adjusting for age, sex, ethnicity, duration of CTS, smoking status, alcohol consumption, employment status, body mass index and comorbidities showed a highly statistically significant relationship between CTS-6 and anxiety, depression and the EQ-5D (p&lt;0.0001 in each case). Likewise, a significant relationship was observed between electrodiagnostic severity and anxiety (p=0.027) but not with depression (p=0.986) or the EQ-5D (p=0.257). National Health Service (NHS) and societal costs in the 3 months prior to enrolment were significantly associated with self-reported severity (p&lt;0.0001) but not with electrodiagnostic severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patient-reported symptom severity in CTS is significantly and positively associated with anxiety, depression, health-related quality of life, and NHS and societal costs even when adjusting for age, gender, body mass index, comorbidities, smoking, drinking and occupational status. In contrast, there is little or no evidence of any relationship with objectively derived CTS severity. Future research is needed to understand the impact of approaches and treatments that address psychosocial stressors as well as biomedical factors on relief of symptoms from carpal tunnel syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2017-017732","type":"journal-article","created":{"date-parts":[[2017,11,4]],"date-time":"2017-11-04T06:30:34Z","timestamp":1509777034000},"page":"e017732","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":41,"title":["Association of psychological distress, quality of life and costs with carpal tunnel syndrome severity: a cross-sectional analysis of the PALMS cohort"],"prefix":"10.1136","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0525-1282","authenticated-orcid":false,"given":"Christina","family":"Jerosch-Herold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Houghton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Blake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anum","family":"Shaikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward CF","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Shepstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,11,3]]},"reference":[{"key":"2024051614485158000_7.11.e017732.1","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/S1474-4422(16)30231-9","article-title":"Carpal tunnel syndrome: clinical features, diagnosis, and management","volume":"15","author":"Padua","year":"2016","journal-title":"Lancet Neurol"},{"key":"2024051614485158000_7.11.e017732.2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000173142.58068.5a"},{"key":"2024051614485158000_7.11.e017732.3","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.066696"},{"key":"2024051614485158000_7.11.e017732.4","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22183"},{"key":"2024051614485158000_7.11.e017732.5","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1177\/1753193416671102","article-title":"Prevalence of decompression surgery in patients with carpal tunnel syndrome 8 years after initial treatment with a local corticosteroid injection","volume":"42","author":"Hameso","year":"2017","journal-title":"J Hand Surg Eur Vol"},{"key":"2024051614485158000_7.11.e017732.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2014.10.011"},{"key":"2024051614485158000_7.11.e017732.7","first-page":"28","article-title":"Variation in CCG policies for the treatment of carpal tunnel syndrome","volume":"99","author":"Ryan","year":"2017","journal-title":"RCS Bulletin"},{"key":"2024051614485158000_7.11.e017732.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2013.05.027"},{"key":"2024051614485158000_7.11.e017732.9","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1551-x"},{"key":"2024051614485158000_7.11.e017732.10","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1111\/pme.12857","article-title":"Direct and Indirect effects of function in associated variables such as depression and severity on pain intensity in women with carpal tunnel syndrome","volume":"16","author":"Fern\u00e1ndez-de-las-Pe\u00f1as","year":"2015","journal-title":"Pain Med"},{"key":"2024051614485158000_7.11.e017732.11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1471-2474-15-35","article-title":"Clinical course, costs and predictive factors for response to treatment in carpal tunnel syndrome: the PALMS study protocol","volume":"15","author":"Jerosch-Herold","year":"2014","journal-title":"BMC Musculoskelet Disord"},{"key":"2024051614485158000_7.11.e017732.12","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4598(200008)23:8<1280::AID-MUS20>3.0.CO;2-Y"},{"key":"2024051614485158000_7.11.e017732.13","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199311000-00002"},{"key":"2024051614485158000_7.11.e017732.14","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-009-9449-3"},{"key":"2024051614485158000_7.11.e017732.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(98)80042-7"},{"key":"2024051614485158000_7.11.e017732.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2004.10.006"},{"key":"2024051614485158000_7.11.e017732.17","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.292.6516.344"},{"key":"2024051614485158000_7.11.e017732.18","doi-asserted-by":"crossref","unstructured":"Group E. 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