{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T01:43:05Z","timestamp":1782783785863,"version":"3.54.5"},"reference-count":17,"publisher":"BMJ","issue":"12","funder":[{"DOI":"10.13039\/100016352","name":"The JED Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100016352","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006282","name":"Koning Boudewijnstichting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006282","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008236","name":"Fondation Roger de Spoelberch","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008236","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2017,10,11]]},"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Preterm and very low birthweight infants are at increased risk for neurodevelopmental disorders, including cerebral palsy, sensory impairment and intellectual disability. Several early intervention approaches have been designed in the hope of optimising neurological development in this context. It seems important that the intervention takes into account parental mental health, focuses on parent\u2013child interactions and lasts sufficiently long. This study aims to evaluate the effects of a stimulation programme administered by parents until 6 months post-term on motor and neurophysiological development of infants born preterm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>Participants will be infants born &lt;32 weeks\u2019 gestation and\/or with a birth weight &lt;1500\u2009g recruited prospectively from two tertiary neonatal intensive care units. They will be randomly assigned to receive nationally recommended follow-up only (control group) or also a stimulation programme between 37 weeks\u2019 gestation and 6 months\u2019 corrected age. Perinatal, clinical neurodevelopmental, socio-demographic and neuroimaging (ultrasonography or MRI) data will be collected. Bayley Scales of Infant Development will be used up to 24 months\u2019 corrected age and Parental Stress Index at 6, 12, 18 and 24 months\u2019 corrected age. High-density (64 or 128 electrodes) EEG, visual, somatosensory and long latency auditory evoked potentials will be recorded at term age, 3, 6, 12, 18 and 24 months\u2019 corrected age. They will be analysed for spatiotemporal frequency bands contents and source localisation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The study was approved by the Ethics Committees of the H\u00f4pital Universitaire des Enfants Reine Fabiola and CHU Saint-Pierre. Results dissemination will be made for stakeholders and families, reports will be written for parents, healthcare providers and policymakers, and scientific papers will be published.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"NCT02159534\" ext-link-type=\"clintrialgov\" specific-use=\"clinicaltrial pre-results\">NCT02159534<\/jats:ext-link>\n                      ; Pre-results.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2017-018084","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:44:24Z","timestamp":1765601064000},"page":"e018084","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Multicentre prospective randomised single-blind controlled study protocol of the effect of an additional parent-administered sensorimotor stimulation on neurological development of preterm infants: Primebrain"],"prefix":"10.1136","volume":"7","clinical-trial-number":[{"clinical-trial-number":"nct02159534","registry":"10.18810\/clinical-trials-gov","type":"preResults"},{"clinical-trial-number":"nct02159534","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Karine","family":"Pelc","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Centre Hospitalier Universitaire Saint-Pierre, Universit\u00e9 libre de Bruxelles (ULB), Brussels, Belgium"},{"name":"Department of Neurology, H\u00f4pital Universitaire des Enfants Reine Fabiola, Universit\u00e9 libre de Bruxelles (ULB), Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irit","family":"Daniel","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Universitaire des Enfants Reine Fabiola, Universit\u00e9 libre de Bruxelles (ULB), Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Wenderickx","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Universitaire des Enfants Reine Fabiola, Universit\u00e9 libre de Bruxelles (ULB), Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Dan","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Universitaire des Enfants Reine Fabiola, Universit\u00e9 libre de Bruxelles (ULB), Brussels, Belgium"},{"name":"Inkendaal Rehabilitation Hospital, Vlezenbeek, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,12,3]]},"reference":[{"key":"2025121220441714000_7.12.e018084.1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2247"},{"key":"2025121220441714000_7.12.e018084.2","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12049"},{"key":"2025121220441714000_7.12.e018084.3","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1001\/jamapediatrics.2015.2175","article-title":"Prognostic factors for poor cognitive development in children born very preterm or with very low birth weight: a systematic review","volume":"169","author":"Linsell","year":"2015","journal-title":"JAMA Pediatr"},{"key":"2025121220441714000_7.12.e018084.4","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12972"},{"key":"2025121220441714000_7.12.e018084.5","first-page":"88","article-title":"Prognostic factors for behavioral problems and psychiatric disorders in children born very preterm or very low birth weight: a systematic review","volume":"37","author":"Linsell","year":"2016","journal-title":"J Dev BehavPediatr"},{"key":"2025121220441714000_7.12.e018084.6","doi-asserted-by":"publisher","DOI":"10.1155\/NP.2001.31"},{"key":"2025121220441714000_7.12.e018084.7","doi-asserted-by":"crossref","unstructured":"Martin J , Friel K , Salimi I , et al . 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