{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:07:48Z","timestamp":1789657668210,"version":"4.0.1"},"reference-count":49,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2017,11,10]]},"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the effect of whole-body vibration exercise (WBV) on fracture risk in adults \u226550 years of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      A systematic review and meta-analysis calculating relative risk ratios, fall rate ratio and absolute weighted mean difference using random effects models. Heterogeneity was estimated using I\n                      <jats:sup>2<\/jats:sup>\n                      statistics, and the Cochrane Collaboration\u2019s risk of bias tool and the GRADE approach were used to evaluate quality of evidence and summarise conclusions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data sources<\/jats:title>\n                    <jats:p>The databases PubMed, Embase and the Cochrane Central Register from inception to April 2016 and reference lists of retrieved publications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Eligibility criteria for selecting studies<\/jats:title>\n                    <jats:p>Randomised controlled trials examining the effect of WBV on fracture risk in adults \u226550 years of age. The primary outcomes were fractures, fall rates and the proportion of participants who fell. Secondary outcomes were bone mineral density (BMD), bone microarchitecture, bone turnover markers and calcaneal broadband attenuation (BUA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      15 papers (14 trials) met the inclusion criteria. Only one study had fracture data reporting a non-significant fracture reduction (risk ratio (RR)=0.47, 95%\u2009CI 0.14 to 1.57, P=0.22) (moderate quality of evidence). Four studies (n=746) showed that WBV reduced the rate of falls with a rate ratio of 0.67 (95% CI 0.50 to 0.89, P=0.0006; I\n                      <jats:sup>2<\/jats:sup>\n                      =19%) (moderate quality of evidence). Furthermore, data from three studies (n=805) found a trend towards falls reduction (RR=0.76, 95%\u2009CI 0.48 to 1.20, P=0.24; I\n                      <jats:sup>2<\/jats:sup>\n                      =24%) (low quality of evidence). Finally, moderate to low quality of evidence showed no overall effect on BMD and only sparse data were available regarding microarchitecture parameters, bone turnover markers and BUA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>WBV reduces fall rate but seems to have no overall effect on BMD or microarchitecture. The impact of WBV on fractures requires further larger adequately powered studies. This meta-analysis suggests that WBV may prevent fractures by reducing falls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"CRD42016036320\">CRD42016036320; Pre-results<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2017-018342","type":"journal-article","created":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T22:35:19Z","timestamp":1514586919000},"page":"e018342","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":76,"title":["Effect of whole-body vibration exercise in preventing falls and fractures: a systematic review and meta-analysis"],"prefix":"10.1136","volume":"7","author":[{"given":"Ditte Beck","family":"Jepsen","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine, Odense University Hospital, Odense, Denmark"},{"name":"Institute of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Research, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Geriatric Medicine, Odense University Hospital, Svendborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stinus","family":"Hansen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Research, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Endocrinology, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas Rye","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark"},{"name":"OPEN\u2014Odense Patient data Explorative Network, Odense University Hospital\/ University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahir","family":"Masud","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Odense University Hospital, Odense, Denmark"},{"name":"Institute of Clinical Research, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Geriatric Medicine, Nottingham University Hospitals NHS Trust, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Ryg","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Odense University Hospital, Odense, Denmark"},{"name":"Institute of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,12,29]]},"reference":[{"key":"2025120519232503000_7.12.e018342.1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-013-0136-1"},{"key":"2025120519232503000_7.12.e018342.2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0172-4"},{"key":"2025120519232503000_7.12.e018342.3","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1811-2"},{"key":"2025120519232503000_7.12.e018342.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53370.x"},{"key":"2025120519232503000_7.12.e018342.5","doi-asserted-by":"publisher","DOI":"10.1007\/BF01623225"},{"key":"2025120519232503000_7.12.e018342.6","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/17.6.365"},{"key":"2025120519232503000_7.12.e018342.7","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1002\/jbmr.2796","article-title":"Microarchitecture and peripheral BMD are impaired in postmenopausal white women with fracture independently of total hip T-score: an international multicenter study","volume":"31","author":"Boutroy","year":"2016","journal-title":"J Bone Miner Res"},{"key":"2025120519232503000_7.12.e018342.8","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-010-1501-1"},{"key":"2025120519232503000_7.12.e018342.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.03.006"},{"key":"2025120519232503000_7.12.e018342.10","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s12603-016-0741-y","article-title":"A Comprehensive Fracture Prevention Strategy in Older Adults: The European Union Geriatric Medicine Society (EUGMS) Statement","volume":"20","author":"Blain","year":"2016","journal-title":"J Nutr Health Aging"},{"key":"2025120519232503000_7.12.e018342.11","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/62.6.630"},{"key":"2025120519232503000_7.12.e018342.12","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.0301245"},{"key":"2025120519232503000_7.12.e018342.13","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-7-92"},{"key":"2025120519232503000_7.12.e018342.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2007.03.028"},{"key":"2025120519232503000_7.12.e018342.15","doi-asserted-by":"publisher","DOI":"10.1038\/35088122"},{"key":"2025120519232503000_7.12.e018342.16","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(01)00689-5"},{"key":"2025120519232503000_7.12.e018342.17","first-page":"1185","article-title":"RANKL is downregulated in bone cells by physical activity (treadmill and vibration stimulation training) in rat with glucocorticoid-induced osteoporosis","volume":"28","author":"Pichler","year":"2013","journal-title":"Histol Histopathol"},{"key":"2025120519232503000_7.12.e018342.18","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.clinbiomech.2010.05.004","article-title":"Muscle activity and acceleration during whole body vibration: effect of frequency and amplitude","volume":"25","author":"Pollock","year":"2010","journal-title":"Clin Biomech"},{"key":"2025120519232503000_7.12.e018342.19","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afu136"},{"key":"2025120519232503000_7.12.e018342.20","first-page":"911","volume-title":"Bone quality in osteopenic postmenopausal women is not improved after 12 months of whole-body vibration training","volume":"2620","author":"Liphardt","year":"2015"},{"key":"2025120519232503000_7.12.e018342.21","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-014-2693-6"},{"key":"2025120519232503000_7.12.e018342.22","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2448"},{"key":"2025120519232503000_7.12.e018342.23","doi-asserted-by":"publisher","DOI":"10.1007\/BF03324589"},{"key":"2025120519232503000_7.12.e018342.24","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1249\/MSS.0b013e318202f3d3","article-title":"Effects of whole-body vibration training on different devices on bone mineral density","volume":"43","author":"Von Stengel","year":"2011","journal-title":"Med Sci Sports Exerc"},{"key":"2025120519232503000_7.12.e018342.25","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jamda.2014.07.018","article-title":"Effects of a whole body vibration (WBV) exercise intervention for institutionalized older people: a randomized, multicentre, parallel, clinical trial","volume":"16","author":"Sitj\u00e0-Rabert","year":"2015","journal-title":"J Am Med Dir Assoc"},{"key":"2025120519232503000_7.12.e018342.26","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s40520-014-0197-z","article-title":"Evaluation of the impact of 6-month training by whole body vibration on the risk of falls among nursing home residents, observed over a 12-month period: a single blind, randomized controlled trial","volume":"26","author":"Buckinx","year":"2014","journal-title":"Aging Clin Exp Res"},{"key":"2025120519232503000_7.12.e018342.27","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-13-42"},{"key":"2025120519232503000_7.12.e018342.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2012.04.009"},{"key":"2025120519232503000_7.12.e018342.29","doi-asserted-by":"publisher","DOI":"10.3109\/09638288.2011.626486"},{"key":"2025120519232503000_7.12.e018342.30","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.maturitas.2014.12.020","article-title":"The effect of whole body vibration exposure on balance and functional mobility in older adults: a systematic review and meta-analysis","volume":"80","author":"Orr","year":"2015","journal-title":"Maturitas"},{"key":"2025120519232503000_7.12.e018342.31","doi-asserted-by":"crossref","first-page":"12:12","DOI":"10.1186\/s11556-015-0158-3","article-title":"Effects of whole-body vibration on proxies of muscle strength in old adults: a systematic review and meta-analysis on the role of physical capacity level","volume":"12","author":"Rogan","year":"2015","journal-title":"Eur Rev Aging Phys Act"},{"key":"2025120519232503000_7.12.e018342.32","doi-asserted-by":"publisher","DOI":"10.1177\/0269215511405078"},{"key":"2025120519232503000_7.12.e018342.33","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-010-1228-z"},{"key":"2025120519232503000_7.12.e018342.34","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3618-3"},{"key":"2025120519232503000_7.12.e018342.35","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13018-016-0357-2","article-title":"Effect of whole-body vibration on reduction of bone loss and fall prevention in postmenopausal women: a meta-analysis and systematic review","volume":"11","author":"Ma","year":"2016","journal-title":"J Orthop Surg Res"},{"key":"2025120519232503000_7.12.e018342.36","unstructured":"HigginsJPT GSe. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. (accessed Mar 2011)."},{"key":"2025120519232503000_7.12.e018342.37","unstructured":"Sch\u00fcnemann HBJ , Guyatt G . Oxman A GRADE handbook for grading quality of evidence and strength of recommendations. The GRADE Working Group. (accessed Oct 2013)."},{"key":"2025120519232503000_7.12.e018342.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.005"},{"key":"2025120519232503000_7.12.e018342.39","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e3181f71063"},{"key":"2025120519232503000_7.12.e018342.40","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jsams.2013.04.020","article-title":"Effects of a short-term whole body vibration intervention on bone mass and structure in elderly people","volume":"17","author":"G\u00f3mez-Cabello","year":"2014","journal-title":"J Sci Med Sport"},{"key":"2025120519232503000_7.12.e018342.41","first-page":"1654","article-title":"Effects of eight months of whole body vibration training on hip bone mass in older women","volume":"31","author":"Santin-Medeiros","year":"2015","journal-title":"Nutr Hosp"},{"key":"2025120519232503000_7.12.e018342.42","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-010-1215-4"},{"key":"2025120519232503000_7.12.e018342.43","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.181"},{"key":"2025120519232503000_7.12.e018342.44","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f6234"},{"key":"2025120519232503000_7.12.e018342.45","first-page":"Cd007146","article-title":"Interventions for preventing falls in older people living in the community","volume":"9","author":"Gillespie","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"2025120519232503000_7.12.e018342.46","doi-asserted-by":"crossref","unstructured":"Sherrington C , Michaleff ZA , Fairhall N , et al . Exercise to prevent falls in older adults: an updated systematic review and meta-analysis. Br J Sports Med 2016.doi: 10.1136\/bjsports-2016-096547. [Epub ahead of print 4 Oct 2016].doi:10.1136\/bjsports-2016-096547","DOI":"10.1136\/bjsports-2016-096547"},{"key":"2025120519232503000_7.12.e018342.47","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-10-201111150-00005"},{"key":"2025120519232503000_7.12.e018342.48","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.06.019"},{"key":"2025120519232503000_7.12.e018342.49","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.5.876"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2017-018342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T03:23:35Z","timestamp":1764991415000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2017-018342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":49,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2017,12,29]]},"published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1136\/bmjopen-2017-018342"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2017-018342","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12]]}}}