{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T17:23:51Z","timestamp":1777742631696,"version":"3.51.4"},"reference-count":26,"publisher":"BMJ","issue":"11","funder":[{"name":"The Southern China International Cooperation Base for Early Intervention and Functional Rehabilitation of Neurological Diseases"},{"name":"Guangzhou Clinical Research and Translational Center for Major Neurological Diseases"},{"name":"Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2017,10,19]]},"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established surgical treatment for Parkinson\u2019s disease (PD). However, there is currently no consensus on the best timing for this surgery. The aim of our study is to compare the therapeutic efficacy of bilateral STN DBS in patients with PD with early and late motor complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>200 patients with PD will be enrolled in this multicentre, prospective, observational study, and will be followed up for 4\u2009years. Patients with PD who meet the criteria for STN DBS surgery will be allocated to either the early stimulation group or the late stimulation group based on the duration of their motor complications. The primary outcome will be changes in quality of life from baseline to 4\u2009years, measured using the 39-item Parkinson\u2019s Disease Questionnaire Summary Index. The secondary outcomes include changes in motor function measured using Movement Disorder Society-revised Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS) Part III, self-reported experiences of daily living measured using MDS-UPDRS Part I B and Part II, good \u2019on' time recorded by the patients using a diary and safety profile of both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The study received ethical approval from the Medical Ethical Committee of the First Affiliated Hospital, Sun Yat-sen University. The results of this study will be published in peer-reviewed journals and presented at international conferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"NCT01922388\" ext-link-type=\"clintrialgov\" specific-use=\"clinicaltrial pre-results\">NCT01922388<\/jats:ext-link>\n                      ; Pre-results.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2017-018610","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T13:18:22Z","timestamp":1715951902000},"page":"e018610","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Early versus Late Application of Subthalamic deep brain Stimulation to Parkinson\u2019s disease patients with motor complications (ELASS): protocol of a multicentre, prospective and observational study"],"prefix":"10.1136","volume":"7","clinical-trial-number":[{"clinical-trial-number":"nct01922388","registry":"10.18810\/clinical-trials-gov","type":"preResults"},{"clinical-trial-number":"nct01922388","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Lulu","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wai Sang","family":"Poon","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Neurosurgery, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, 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