{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T10:52:42Z","timestamp":1756810362218,"version":"3.37.3"},"reference-count":38,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,10,17]]},"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To report the resource use, characteristics and outcomes of patients with prolonged non-invasive ventilation (NIV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A single-centre observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>An intensive care unit of a teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Patients who only received NIV because of acute respiratory failure were enrolled. Prolonged NIV was defined as subjects who received NIV \u226514 days. A total of 1539 subjects were enrolled in this study; 69 (4.5%) underwent prolonged NIV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Predictors of prolonged NIV and hospital mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rate of do-not-intubate (DNI) orders was 9.1% (140\/1539). At the beginning of NIV, a DNI order (OR 3.95, 95%\u2009CI 2.25 to 6.95) and pH \u22657.35 (2.20, 1.27 to 3.82) were independently associated with prolonged NIV. At days 1 and 7 of NIV, heart rate (1.01 (1.00 to 1.03) and 1.02 (1.00 to 1.03], respectively) and PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub>&lt;150 (2.19 (1.25 to 3.85) and 2.05 (1.04 to 4.04], respectively) were other independent risk factors for prolonged NIV. When patients who died after starting NIV but prior to 14 days were excluded, the association was strengthened. Regarding resource use, 77.1% of subjects received NIV&lt;7 days and only accounted for 47.0% of NIV-days. However, 18.4% of subjects received NIV 7\u201313.9 days and accounted for 33.4% of NIV-days, 2.9% of subjects received NIV 14\u201320.9 days and accounted for 9.5% of NIV-days, and 1.6% of subjects received NIV\u226521 days and accounted for 10.1% of NIV-days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate the resource use, characteristics and outcomes of a prolonged NIV population with a relatively high proportion of DNI orders. Subjects with prolonged NIV make up a high proportion of NIV-days and are at high risk for in-hospital mortality.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2017-019271","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T10:05:59Z","timestamp":1544004359000},"page":"e019271","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Resource use, characteristics and outcomes of prolonged non-invasive ventilation: a single-centre observational study in China"],"prefix":"10.1136","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1685-0117","authenticated-orcid":false,"given":"Jun","family":"Duan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linfu","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lintong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shicong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,12,4]]},"reference":[{"key":"2024051710493215000_8.12.e019271.1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-226OC"},{"key":"2024051710493215000_8.12.e019271.2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.111.6.1639"},{"key":"2024051710493215000_8.12.e019271.3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200301-072OC"},{"key":"2024051710493215000_8.12.e019271.4","doi-asserted-by":"crossref","unstructured":"Ram FS , Picot J , Lightowler J , et al . 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