{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:42:11Z","timestamp":1777635731481,"version":"3.51.4"},"reference-count":42,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2017,12,7]]},"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Fracture healing is a complex physiological process. Impaired healing will increase the need for care and cause serious complications. Thus, identifying strategies to accelerate the rate of healing, preventing delayed unions and non-unions, is essential. Parathyroid hormone (PTH) is a key systemic regulator of calcium and phosphate metabolism. It has been determined that intermittent administration of PTH and its analogue can exert anabolic effect on bone, increase bone mass and reduce bone loss, leading to an increase in bone formation. Owing to their anabolic effect, there is an increasing interest in its potential in promoting the process of fracture healing. However, in clinical studies, the results are in conflict. This objective of this study is to determine the role of PTH analogues for fracture healing in adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>MEDLINE, EMBASE and Cochrane databases will be searched to identify all randomised controlled trials (RCTs) and quasi-RCTs that compare the different effects between PTH analogues and any other treatments in adults with any type of fracture. The primary outcome is the functional recovery. And the secondary outcomes are fracture union and adverse events. The meta-analysis will be performed using a random effects model. Heterogeneity will be assessed by the P values and I\u00b2 statistic. And subgroup analyses and sensitivity analyses will be used to explore the heterogeneity. Risk of bias will be assessed using the Cochrane tool and the quality of evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Ethical approval is not required because this proposed systematic review and meta-analysis is based on published data, without including confidential personal data or data on interventions on patients. The findings of this study will be published in a peer-reviewed journaland presented at a relevant conference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"CRD42017062093\">CRD42017062093<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2017-019291","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T04:50:53Z","timestamp":1516683053000},"page":"e019291","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Parathyroid hormone analogues for fracture healing: protocol for a systematic review and meta-analysis of randomised controlled trials"],"prefix":"10.1136","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8826-3160","authenticated-orcid":false,"given":"Shenghan","family":"Lou","sequence":"first","affiliation":[{"name":"Department of Spine Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, People\u2019s Republic of China"},{"name":"Department of Orthopedics, Chinese PLA General Hospital, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houchen","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Chinese PLA General Hospital, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhirui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Chinese PLA General Hospital, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4279-1704","authenticated-orcid":false,"given":"Peifu","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Chinese PLA General Hospital, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yansong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,1,23]]},"reference":[{"key":"2025121410491798000_8.1.e019291.1","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.injury.2013.08.003","article-title":"Fracture non-union: who is at risk?","volume":"44","author":"Copuroglu","year":"2013","journal-title":"Injury"},{"key":"2025121410491798000_8.1.e019291.2","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1007\/s00198-011-1611-4","article-title":"Bone fracture and bone fracture repair","volume":"22","author":"Fazzalari","year":"2011","journal-title":"Osteoporos Int"},{"key":"2025121410491798000_8.1.e019291.3","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-011-0065-0"},{"key":"2025121410491798000_8.1.e019291.4","doi-asserted-by":"publisher","DOI":"10.1038\/nature01660"},{"key":"2025121410491798000_8.1.e019291.5","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00448-8"},{"key":"2025121410491798000_8.1.e019291.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105103441904"},{"key":"2025121410491798000_8.1.e019291.7","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1346.043"},{"key":"2025121410491798000_8.1.e019291.8","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-5-200703060-00005"},{"key":"2025121410491798000_8.1.e019291.9","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1007\/s40265-017-0780-7","article-title":"Abaloparatide: first global approval","volume":"77","author":"Shirley","year":"2017","journal-title":"Drugs"},{"key":"2025121410491798000_8.1.e019291.10","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2011.624631"},{"key":"2025121410491798000_8.1.e019291.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.03.017"},{"key":"2025121410491798000_8.1.e019291.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(02)00056-7"},{"key":"2025121410491798000_8.1.e019291.13","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-14-6-690"},{"key":"2025121410491798000_8.1.e019291.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0690(02)00074-5"},{"key":"2025121410491798000_8.1.e019291.15","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s00198-013-2596-y","article-title":"The effects of once-weekly teriparatide on hip structure and biomechanical properties assessed by CT","volume":"25","author":"Ito","year":"2014","journal-title":"Osteoporos Int"},{"key":"2025121410491798000_8.1.e019291.16","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/jbmr.3003","article-title":"One year of abaloparatide, a selective activator of the PTH1 receptor, increased bone formation and bone mass in osteopenic ovariectomized rats without increasing bone resorption","volume":"32","author":"Varela","year":"2017","journal-title":"J Bone Miner Res"},{"key":"2025121410491798000_8.1.e019291.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.02.002"},{"key":"2025121410491798000_8.1.e019291.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.05.013"},{"key":"2025121410491798000_8.1.e019291.19","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20427"},{"key":"2025121410491798000_8.1.e019291.20","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-011-1751-6"},{"key":"2025121410491798000_8.1.e019291.21","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.D.02115"},{"key":"2025121410491798000_8.1.e019291.22","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/538019"},{"key":"2025121410491798000_8.1.e019291.23","unstructured":"Cheung AM , Tile L , Austin N , et al . Use of teriparatide in patients with atypical femur fractures. J Bone Miner Res 2011:26."},{"key":"2025121410491798000_8.1.e019291.24","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.16.00230"},{"key":"2025121410491798000_8.1.e019291.25","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005361"},{"key":"2025121410491798000_8.1.e019291.26","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.J.01379"},{"key":"2025121410491798000_8.1.e019291.27","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000006571","article-title":"Teriparatide as a nonoperative treatment for tibial and femoral fracture nonunion: A case report","volume":"96","author":"Xiaofeng","year":"2017","journal-title":"Medicine"},{"key":"2025121410491798000_8.1.e019291.28","doi-asserted-by":"crossref","first-page":"148","DOI":"10.5371\/hp.2016.28.3.148","article-title":"Adjuvant teriparatide therapy for surgical treatment of femoral fractures; does it work?","volume":"28","author":"Kim","year":"2016","journal-title":"Hip Pelvis"},{"key":"2025121410491798000_8.1.e019291.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2015.06.033"},{"key":"2025121410491798000_8.1.e019291.30","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2015.1073050"},{"key":"2025121410491798000_8.1.e019291.31","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/17453674.2017.1300745","article-title":"No effect of teriparatide on migration in total knee replacement","volume":"88","author":"Ledin","year":"2017","journal-title":"Acta Orthop"},{"key":"2025121410491798000_8.1.e019291.32","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1007\/s11999-015-4669-z","article-title":"Does Teriparatide Improve Femoral Neck Fracture Healing: Results From A Randomized Placebo-controlled Trial","volume":"474","author":"Bhandari","year":"2016","journal-title":"Clin Orthop Relat Res"},{"key":"2025121410491798000_8.1.e019291.33","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-012-9587-4"},{"key":"2025121410491798000_8.1.e019291.34","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"2025121410491798000_8.1.e019291.35","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j656"},{"key":"2025121410491798000_8.1.e019291.36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/708574","article-title":"Current options for determining fracture union","volume":"2014","author":"Morshed","year":"2014","journal-title":"Adv Med"},{"key":"2025121410491798000_8.1.e019291.37","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"2025121410491798000_8.1.e019291.38","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"2025121410491798000_8.1.e019291.39","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"2025121410491798000_8.1.e019291.40","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(01)00377-8"},{"key":"2025121410491798000_8.1.e019291.41","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"2025121410491798000_8.1.e019291.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.09.011"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2017-019291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T18:49:22Z","timestamp":1765738162000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2017-019291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1,23]]},"published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1136\/bmjopen-2017-019291"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2017-019291","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]}}}