{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T23:21:55Z","timestamp":1783984915652,"version":"3.55.0"},"reference-count":24,"publisher":"BMJ","issue":"2","funder":[{"DOI":"10.13039\/100001275","name":"Oak Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001275","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Danish Rheumatism Association"},{"name":"Research Fund of Hospital South, Region Zealand"},{"name":"Edith and Henrik Henriksens Memorial Fund"},{"name":"Region Zealand Health Scientific Research Fund"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2017,12,22]]},"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Compare arthroscopic partial meniscectomy to a true sham intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sham-controlled superiority trial performed in three county hospitals in Denmark comparing arthroscopic partial meniscectomy to skin incisions only in patients aged 35\u201355 years with persistent knee pain and an MRI-confirmed medial meniscus lesion. A computer-generated table of random numbers generated two comparison groups. Participants and outcome assessors were blinded to group allocation. Exclusions were locking knees, high-energy trauma or severe osteoarthritis. Outcomes were collected at baseline, 3 and 24 months. We hypothesised no difference between groups. The primary outcome was the between-group difference in change from baseline to 2 years in the mean score across all five normalised Knee injury and Osteoarthritis Outcome Score (KOOS) subscales (KOOS\n                      <jats:sub>5<\/jats:sub>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty-four patients (of the estimated 72) underwent randomisation; 22 in each group. Sixteen participants (36%) were non-blinded and eight participants (36%) from the sham group crossed over to the surgery group prior to the 2-year follow-up. At 2\u2009years, both groups reported clinically relevant improvements (surgery 21.8, skin incisions only 13.6), the mean difference between groups was 8.2 in favour of surgery, which is slightly less than the cut-off of 10 prespecified to represent a clinically relevant difference; judged by the 95% CI (\u22123.4 to 19.8), a possibility of clinically relevant difference could not be excluded. In total, nine participants experienced 11 adverse events; six in the surgery group and three in the skin-incisions-only group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found greater improvement from arthroscopic partial meniscectomy compared with skin incisions only at 2 years, with the statistical uncertainty of the between-group difference including what could be considered clinically relevant. Because of the study being underpowered, nearly half in the sham group being non-blinded and one-third crossing over to surgery, the results cannot be generalised to the greater patient population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"NCT01264991\" ext-link-type=\"clintrialgov\">NCT01264991<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2017-019461","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T09:40:48Z","timestamp":1517564448000},"page":"e019461","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Better outcome from arthroscopic partial meniscectomy than skin incisions only? A sham-controlled randomised trial in patients aged 35\u201355 years with knee pain and an MRI-verified meniscal tear"],"prefix":"10.1136","volume":"8","clinical-trial-number":[{"clinical-trial-number":"nct01264991","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct01264991","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5425-2199","authenticated-orcid":false,"given":"Ewa M","family":"Roos","sequence":"first","affiliation":[{"name":"Department of Sport and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristoffer Borbjerg","family":"Hare","sequence":"additional","affiliation":[{"name":"Department of Sport and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Orthopaedics, Slagelse Hospital, Slagelse, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina Mai","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6600-0631","authenticated-orcid":false,"given":"Robin","family":"Christensen","sequence":"additional","affiliation":[{"name":"Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L Stefan","family":"Lohmander","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Orthopaedics, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,2,2]]},"reference":[{"key":"2025121422324315000_8.2.e019461.1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204763"},{"key":"2025121422324315000_8.2.e019461.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.01.003"},{"key":"2025121422324315000_8.2.e019461.3","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21596"},{"key":"2025121422324315000_8.2.e019461.4","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202745"},{"key":"2025121422324315000_8.2.e019461.5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h2747"},{"key":"2025121422324315000_8.2.e019461.6","doi-asserted-by":"crossref","unstructured":"Monk P , Garfjeld Roberts P , Palmer AJ , et al . The Urgent Need for Evidence in Arthroscopic Meniscal Surgery: A Systematic Review of the Evidence for Operative Management of Meniscal Tears. Am J Sports Med 2016.","DOI":"10.1177\/0363546516650180"},{"key":"2025121422324315000_8.2.e019461.7","doi-asserted-by":"publisher","DOI":"10.1177\/0363546513488518"},{"key":"2025121422324315000_8.2.e019461.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1305189"},{"key":"2025121422324315000_8.2.e019461.9","unstructured":"Kise NJ , Risberg MA , Stensrud S , et al . Exercise therapy versus arthroscopic partial menisectomy; Effect on mechanical symptoms. The 13th Scandinavian Congress of Medicine and Science in Sports. Norefjell, Norway 2016."},{"key":"2025121422324315000_8.2.e019461.10","first-page":"1260","article-title":"Arthroscopic partial meniscectomy for degenerative meniscal tear","volume":"370","author":"Lattermann","year":"2014","journal-title":"N Engl J Med"},{"key":"2025121422324315000_8.2.e019461.11","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.01618"},{"key":"2025121422324315000_8.2.e019461.12","doi-asserted-by":"publisher","DOI":"10.1177\/0363546513479771"},{"key":"2025121422324315000_8.2.e019461.13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013259"},{"key":"2025121422324315000_8.2.e019461.14","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208387"},{"key":"2025121422324315000_8.2.e019461.15","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g3253"},{"key":"2025121422324315000_8.2.e019461.16","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-009655","article-title":"To what extent are surgery and invasive procedures effective beyond a placebo response? 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