{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T08:05:41Z","timestamp":1769241941182,"version":"3.49.0"},"reference-count":13,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2017,12,14]]},"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study is to collate multi-institutional data to determine the value by defining the diagnostic performance of fluorodeoxyglucose positron emission tomography (FDG PET)\/CT for malignancy in patients undergoing surgery with an anterior mediastinal mass in order to ascertain the clinical utility of PET\/CT to differentiate malignant from benign aetiologies in patients presenting with an anterior mediastinal mass<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>DECiMaL Study is a multicentre, retrospective, collaborative cohort study in seven UK surgical sites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Between January 2002 and June 2015, a total of 134 patients were submitted with a mean age (SD) of 55 years (16) of which 69 (51%) were men. We included all patients undergoing surgery who presented with an anterior mediastinal mass and underwent PET\/CT. PET\/CT was considered positive for any reported avidity as stated in the official report and the reference was the resected specimen reported by histopathology using WHO criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>Sensitivity, specificity, positive and negative predicted values of [18F]-FDG PET in determining malignant aetiology for an anterior mediastinal mass.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The sensitivity and specificity of PET\/CT to correctly classify malignant disease were 83% (95% CI 74 to 89) and 58% (95% CI 37 to 78). The positive and negative predictive values were 90% (95% CI 83% to 95%) and 42% (95% CI 26% to 61%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results of our study suggest reasonable sensitivity but no specificity implying that a negative PET\/CT is useful to rule out the diagnosis of malignant disease whereas a positive result has no value in the discrimination between malignant and benign diseases of the anterior mediastinum.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2017-019471","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T12:40:25Z","timestamp":1518525625000},"page":"e019471","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["A diagnostic cohort study on the accuracy of 18-fluorodeoxyglucose (\n                    <sup>18<\/sup>\n                    FDG) positron emission tomography (PET)-CT for evaluation of malignancy in anterior mediastinal lesions: the DECiMaL study"],"prefix":"10.1136","volume":"8","author":[{"given":"Chiara","family":"Proli","sequence":"first","affiliation":[{"name":"Imperial College and the Academic Division of Thoracic Surgery, Royal Brompton and Harefield NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3011-4116","authenticated-orcid":false,"given":"Paulo","family":"De Sousa","sequence":"additional","affiliation":[{"name":"Imperial College and the Academic Division of Thoracic Surgery, Royal Brompton and Harefield NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Jordan","sequence":"additional","affiliation":[{"name":"Imperial College and the Academic Division of Thoracic Surgery, Royal Brompton and Harefield NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Anikin","sequence":"additional","affiliation":[{"name":"Imperial College and the Academic Division of Thoracic Surgery, Royal Brompton and Harefield NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand","family":"Devaraj","sequence":"additional","affiliation":[{"name":"Imperial College and the Academic Division of Thoracic Surgery, Royal Brompton and Harefield NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susannah M","family":"Love","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Liverpool Heart and Chest Hospital NHS Trust, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Shackcloth","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Liverpool Heart and Chest Hospital NHS Trust, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Kostoulas","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kostas","family":"Papagiannopoulos","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yama","family":"Haqzad","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Hull and East Yorkshire Hospitals NHS Trust, Hull, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Loubani","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Hull and East Yorkshire Hospitals NHS Trust, Hull, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Sellitri","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felice","family":"Granato","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Bush","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Plymouth Hospitals NHS Trust, Plymouth, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Marchbank","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Plymouth Hospitals NHS Trust, Plymouth, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swetha","family":"Iyer","sequence":"additional","affiliation":[{"name":"Thoracic Services, Papworth Hospital NHS Foundation Trust, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Scarci","sequence":"additional","affiliation":[{"name":"Thoracic Services, Papworth Hospital NHS Foundation Trust, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Lim","sequence":"additional","affiliation":[{"name":"Imperial College and the Academic Division of Thoracic Surgery, Royal Brompton and Harefield NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,2,6]]},"reference":[{"key":"2025121407573353000_8.2.e019471.1","unstructured":"The Royal College of Radiologists. 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