{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:06:35Z","timestamp":1784891195035,"version":"3.55.0"},"reference-count":35,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,2,16]]},"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Truncal vagotomy is associated with a decreased risk of subsequent Parkinson disease (PD), although the effect of vagotomy on dementia is unclear. In response, we investigated the risk of dementia in patients who underwent vagotomy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Population-based cohort study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>A total of 155\u2009944 patients who underwent vagotomy (vagotomy cohort) and 155\u2009944 age-matched, sex-matched and comorbidity-matched controls (non-vagotomy cohort) were identified between 2000 and 2011.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Primary and secondary outcome measures<\/jats:title>\n                  <jats:p>All patient data were tracked until the diagnosis of dementia, death or the end of 2011. The cumulative incidence of subsequent dementia and HRs were calculated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean ages of the study patients in the vagotomy and non-vagotomy cohorts were 56.6\u00b117.4\u2009and 56.7\u00b117.3 years, respectively. The overall incidence density rate for dementia was similar in the vagotomy and non-vagotomy cohorts (2.43 and 2.84 per 1000 person-years, respectively). After adjustment for age, sex and comorbidities such as diabetes, hypertension, hyperlipidaemia, stroke, depression, coronary artery disease and PD, the patients in the vagotomy cohort were determined to not be at a higher risk of dementia than those in the non-vagotomy cohort (adjusted HR=1.09, 95% CI 0.87 to 1.36). Moreover, the patients who underwent truncal vagotomy were not associated with risk of dementia (adjusted HR=1.04, 95%\u2009CI 0.87 to 1.25), compared with the patients who did not undergo vagotomy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Vagotomy, either truncal or selective, is not associated with risk of dementia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2017-019582","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T09:25:48Z","timestamp":1522401948000},"page":"e019582","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Dementia and vagotomy in Taiwan: a population-based cohort study"],"prefix":"10.1136","volume":"8","author":[{"given":"Shih-Yi","family":"Lin","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan"},{"name":"Division of Nephrology and Kidney Institute, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Li","family":"Lin","sequence":"additional","affiliation":[{"name":"Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan"},{"name":"College of Medicine, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Kuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan"},{"name":"Division of Nephrology and Kidney Institute, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Chieh","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan"},{"name":"Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hsueh","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan"},{"name":"Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu-Huei","family":"Hsu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan"},{"name":"Division of Pulmonary and Critical Care Medicine, China Medical University Hospital and China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6368-3676","authenticated-orcid":false,"given":"Chia-Hung","family":"Kao","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan"},{"name":"Department of Nuclear Medicine, China Medical University Hospital, Taichung, Taiwan"},{"name":"Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"2025101814541750000_8.3.e019582.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.11.006"},{"key":"2025101814541750000_8.3.e019582.2","unstructured":"World Health Organization. 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