{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:43:52Z","timestamp":1788781432220,"version":"build-2803163510"},"reference-count":15,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,7,31]]},"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Hypertrophic cardiomyopathy (HCM) entails thickening of the myocardium and an increased risk of ischaemia. However, the prognosis of patients with HCM with acute myocardial infarction (AMI) is incompletely understood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Medical information was retrieved from the Taiwan National Health Insurance Research Database in 1997\u20132011. The exclusion criteria were patients &lt;18 years old, and history of AMI, coronary intervention, aortic valve disease, disease of the pericardium, heart surgery, device implantation, venous thromboembolism, cardiac transplant, congenital heart disease and end-stage renal disease on dialysis. Patients with HCM with AMI were compared with propensity score (PS)-matched patients with AMI without HCM. The primary endpoints were in-hospital and 1-year cardiovascular events.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 201\u2009166 patients were admitted for AMI. There were 177\u2009058 patients with new-onset AMI, 257 with HCM and 176\u2009801 without HCM after exclusion criteria. Using 1:4 PS matching, the study population consisted of patients with AMI, 257 with HCM and 1028 without HCM. Patients with AMI with HCM received significantly less coronary intervention (OR=0.46; 95% CI 0.32 to 0.65; p&lt;0.001), coronary intervention with stenting (OR=0.33; 95% CI 0.20 to 0.57; p&lt;0.001) and coronary artery bypass graft surgery (OR=0.22; 95% CI 0.05 to 0.90; p=0.036), and fewer episodes of shock (OR=0.64; 95% CI 0.48 to 0.86; p=0.003) and in-hospital death (OR=0.46; 95% CI 0.30 to 0.70; p&lt;0.001), compared with patients with AMI without HCM. Specifically, for patients with HCM with AMI, AMI occurred predominantly (82.5%) in the form of ischaemia without requiring coronary stenting. Patients with AMI with HCM had significantly better survival than patients without HCM (HR=0.66; 95% CI 0.51 to 0.85; p=0.001) during the 1-year follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This is the first PS-matched study to compare the prognosis of patients with AMI with and without HCM. Compared with patients with AMI without HCM, patients with HCM had significantly better in-hospital and within 1-year outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2017-019741","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T07:05:10Z","timestamp":1535007910000},"page":"e019741","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Outcomes of patients with hypertrophic cardiomyopathy and acute myocardial infarction: a propensity score-matched, 15-year nationwide population-based study in Asia"],"prefix":"10.1136","volume":"8","author":[{"given":"Victor Chien-Chia","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien-Hsing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Chang Gung Memorial Hospital Keelung Branch, Keelung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Miriam and Rhode Island Hospital, Warren Alpert School of Medicine, Brown University, Providence, Rhode Island, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hsiang","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Wei","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, Taiwan"},{"name":"Department of Neurosurgery, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Chang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie Pei-Hsuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Jer","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Yung","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang-Hung","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen-Chiung","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Chang","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pao-Hsien","family":"Chu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Shien","family":"Wen","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,8,23]]},"reference":[{"key":"2025101815103155000_8.8.e019741.1","first-page":"2733","article-title":"ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC)","volume":"2014","author":"Elliott","year":"2014","journal-title":"Eur Heart J"},{"key":"2025101815103155000_8.8.e019741.2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.4.785"},{"key":"2025101815103155000_8.8.e019741.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.3.230"},{"key":"2025101815103155000_8.8.e019741.4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.7.650"},{"key":"2025101815103155000_8.8.e019741.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.05.003"},{"key":"2025101815103155000_8.8.e019741.6","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20057"},{"key":"2025101815103155000_8.8.e019741.7","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/clc.22601","article-title":"Long-term survival after acute myocardial infarction in patients with hypertrophic cardiomyopathy","volume":"40","author":"Yang","year":"2017","journal-title":"Clin Cardiol"},{"key":"2025101815103155000_8.8.e019741.8","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.amjmed.2015.02.025","article-title":"Outcomes of acute myocardial infarction in patients with hypertrophic cardiomyopathy","volume":"128","author":"Gupta","year":"2015","journal-title":"Am J Med"},{"key":"2025101815103155000_8.8.e019741.9","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31826e1058"},{"key":"2025101815103155000_8.8.e019741.10","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318223e230"},{"key":"2025101815103155000_8.8.e019741.11","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu284"},{"key":"2025101815103155000_8.8.e019741.12","unstructured":"Hicks KA , Hung HMJ , Mahaffey KW , et al . Standardized definitions for end point events in cardiovascular trials. US Food & Drug Administration 2010."},{"key":"2025101815103155000_8.8.e019741.13","doi-asserted-by":"publisher","DOI":"10.1001\/2012.jama.11975"},{"key":"2025101815103155000_8.8.e019741.14","doi-asserted-by":"publisher","DOI":"10.2307\/2670170"},{"key":"2025101815103155000_8.8.e019741.15","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2174"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2017-019741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T22:10:38Z","timestamp":1760825438000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2017-019741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":15,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8,23]]},"published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1136\/bmjopen-2017-019741"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2017-019741","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8]]}}}