{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:37:29Z","timestamp":1787017049976,"version":"build-2736575974"},"reference-count":36,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2017,12,18]]},"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to assess the relationship between infection with multiple human papillomavirus (HPV) types and abnormal anal cytology in HIV-infected men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>An observational, cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>A regional referral hospital in Taiwan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>In total, 714 HIV-infected men were enrolled between March 2011 and June 2016. Thin preparation anal Pap smears were interpreted according to the 2001 Bethesda System. Thirty-seven types of HPV were detected by reverse line blotting, including 13 oncogenic types and 24 non-oncogenic types.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome measures<\/jats:title>\n                    <jats:p>The relationship between anal HPV infection and abnormal anal cytology in people of Asian ethnicity and the coverage efficacy in HPV-vaccinated HIV-infected men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      On anal cytology, 175 (24.5%) subjects had atypical squamous cells of undetermined significance (ASCUS) or higher grades of dysplasia, including 87 (49.7%) with ASCUS, 73 (41.7%) with low-grade squamous intraepithelial lesions (LSILs) and 15 (8.6%) with high-grade squamous intraepithelial lesions (HSILs). A higher proportion of subjects with those without LSIL\/HSIL (93.1% vs 67.3%, P&lt;0.0001) had multiple HPV types. The odds of having LSIL\/HSIL increased with an increasing number of HPV types: the ORs ranged from 1 for no HPV types to 6.96 (95% CI 2.38 to 20.37) for more than five types (P\n                      <jats:sub>trend<\/jats:sub>\n                      &lt;0.0001). Multivariate logistic regression analysis showed a significant association between LSIL\/HSIL and the number of HPV genotypes present (OR 1.20; 95% CI 1.02 to 1.42, P&lt;0.05). HPV types covered by the nonavalent HPV vaccine (types 6\/11\/16\/18\/31\/33\/45\/52\/58) were detected in 70.1% of the patients in this study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The odds of having anal LSIL\/HSIL are approximately seventimes greater in HIV-infected men with than withoutsix or more types of HPV. Multiple HPV types in HIV-infected patients deserves aggressive follow-up, and HPV vaccination programme require scaling up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2017-019894","type":"journal-article","created":{"date-parts":[[2018,1,27]],"date-time":"2018-01-27T07:25:27Z","timestamp":1517037927000},"page":"e019894","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Multiple types of human papillomavirus infection and anal precancerous lesions in HIV-infected men in Taiwan: a cross-sectional study"],"prefix":"10.1136","volume":"8","author":[{"given":"Shu-Hsing","family":"Cheng","sequence":"first","affiliation":[{"name":"School of Public Health, Taipei Medical University, Taipei, Taiwan"},{"name":"Department of Infectious Diseases, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Sheng","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Yu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan"},{"name":"School of Public Health, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Yeh","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science and Biotechnology, Yuanpei University of Medical Technology, Hsinchu, Taiwan"},{"name":"Graduate School of Biotechnology and Bioengineering, Yuan Ze University, Taoyuan, Taiwan"},{"name":"School of Medical Laboratory Science and Biotechnology, Taipei Medical University, Taipei, Taiwan"},{"name":"Department of Clinical Pathology, Far Eastern Memorial Hospital, New Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,1,27]]},"reference":[{"key":"2025121400254776000_8.1.e019894.1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23744"},{"key":"2025121400254776000_8.1.e019894.2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.18.1500"},{"key":"2025121400254776000_8.1.e019894.3","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31817aebfe"},{"key":"2025121400254776000_8.1.e019894.4","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24116"},{"key":"2025121400254776000_8.1.e019894.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09712.x"},{"key":"2025121400254776000_8.1.e019894.6","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1071\/SH11139","article-title":"Prevalence and predictors of high-grade anal intraepithelial neoplasia in a community-based sample of homosexual men","volume":"9","author":"Hillman","year":"2012","journal-title":"Sex Health"},{"key":"2025121400254776000_8.1.e019894.7","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/DCR.0b013e3181e10842","article-title":"Detection of oncogenic human papillomavirus impacts anal screening guidelines in men who have sex with men","volume":"53","author":"Goldstone","year":"2010","journal-title":"Dis Colon Rectum"},{"key":"2025121400254776000_8.1.e019894.8","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.143"},{"key":"2025121400254776000_8.1.e019894.9","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25671"},{"key":"2025121400254776000_8.1.e019894.10","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu052"},{"key":"2025121400254776000_8.1.e019894.11","unstructured":"Center for Disease Control. 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