{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:04:01Z","timestamp":1785542641879,"version":"3.56.0"},"reference-count":15,"publisher":"BMJ","issue":"5","funder":[{"DOI":"10.13039\/501100004166","name":"Warszawski Uniwersytet Medyczny","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the efficacy of gelatine tannate (a complex of tannic acid with astringent and anti-inflammatory properties, and a protective gelatine) for the treatment of acute gastroenteritis (AGE) in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Randomised, double-blind, placebo-controlled trial. Intention-to-treat analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Two paediatric hospitals in Warsaw.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Children younger than 5 years of age with AGE, defined as a change in stool consistency to a loose or liquid form (according to the Bristol Stool Form Scale or Amsterdam Stool Form Scale) and\/or an increase in the frequency of evacuations (\u22653 in 24\u2009hours), lasting for no longer than 5 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>Seventy-two children were assigned to receive gelatine tannate (n=36) or placebo (n=36) in addition to standard rehydration therapy. The gelatine tannate was administered at an age-dependent dose (250\u2013500\u2009mg), and both study products were taken four times per day for 5 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Primary and secondary outcome measures<\/jats:title><jats:p>The main outcome measure was duration of diarrhoea. Secondary outcomes included the need for intravenous rehydration, need for hospitalisation of outpatients, number of watery stools per day, vomiting, weight gain, adverse events, recurrence of diarrhoea, severity of diarrhoea according to the Vesikari Scale and use of concomitant medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty-four children (89%) completed the intervention and were included in the analysis. The duration of diarrhoea after randomisation was similar in the gelatine tannate and placebo groups (75.6\u00b127.8 vs 75.5\u00b129.0\u2009hours, respectively, mean difference 0.1\u2009hours, 95%\u2009CI \u221214.1 to 14.3\u2009hours). There was no significant difference between groups in the number of watery stools per day throughout the study period. There were also no differences in any other secondary outcome measures between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In children with AGE younger than 5 years of age, gelatine tannate was ineffective as an adjunct to rehydration therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration number<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"NCT02280759\" ext-link-type=\"clintrialgov\" specific-use=\"clinicaltrial\">NCT02280759<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2017-020205","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T18:01:31Z","timestamp":1680717691000},"page":"e020205","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Gelatine tannate in the management of acute gastroenteritis in children: a randomised controlled trial"],"prefix":"10.1136","volume":"8","clinical-trial-number":[{"clinical-trial-number":"nct02280759","registry":"10.18810\/clinical-trials-gov","type":"preResults"},{"clinical-trial-number":"nct02280759","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Maciej","family":"Ko\u0142odziej","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Bebenek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zofia","family":"Konarska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hania","family":"Szajewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,5,24]]},"reference":[{"key":"2023040221233360000_8.5.e020205.1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000375"},{"issue":"Suppl 1","key":"2023040221233360000_8.5.e020205.2","first-page":"A75","article-title":"Undissociated gelatin tannate reduces intestinal leakiness and mucosa inflammation by forming a protective biofilm: results from in-vitro and in-vivo studies","volume":"1","author":"Bueno","year":"2013","journal-title":"Gastroenterol J"},{"key":"2023040221233360000_8.5.e020205.3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1472-765X.1993.tb01428.x","article-title":"Growth inhibition of selected food-borne bacteria by tannic acid, propyl gallate and related compounds","volume":"17","author":"Chung","year":"1993","journal-title":"Lett Appl Microbiol"},{"key":"2023040221233360000_8.5.e020205.4","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(91)83426-L"},{"key":"2023040221233360000_8.5.e020205.5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052709499"},{"key":"2023040221233360000_8.5.e020205.6","first-page":"61","article-title":"Gelatin tannate reduces the proinflammatory effects of lipopolysaccharide in human intestinal epithelial cells","volume":"5","author":"Frasca","year":"2012","journal-title":"Clin Exp Gastroenterol"},{"key":"2023040221233360000_8.5.e020205.7","first-page":"121","article-title":"Gelatin tannate for treating acute gastroenteritis: a systematic review","volume":"27","author":"Ruszczy\u0144ski","year":"2014","journal-title":"Ann Gastroenterol"},{"key":"2023040221233360000_8.5.e020205.8","doi-asserted-by":"crossref","unstructured":"Micha\u0142ek D , Ko\u0142odziej M , Konarska Z , et al . 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