{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:31:42Z","timestamp":1790116302968,"version":"4.0.1"},"reference-count":49,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,7,27]]},"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The clinical implications of blood eosinophil level in patients with chronic obstructive pulmonary disease (COPD) and community-acquired pneumonia (CAP) requiring invasive mechanical ventilation (IMV) and intensive care unit (ICU) admission are still unknown. Thus, this study aimed to compare the features of such patients with and without blood eosinophilia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>This was a retrospective case\u2013control study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>An ICU of a medical centre in central Taiwan.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>A total of 262 patients with COPD and CAP requiring IMV and ICU admission.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of all participants (n=262), 32 (12.2%) had an eosinophil percentage (EP) &gt;2%\u2009and 169 (64.5%) had an absolute eosinophil count (AEC) &gt;300\u2009cells\/\u00b5L. Regardless of whether 2% or 300\u2009cells\/\u00b5L was used as a cut-off value, the eosinophilia group were slightly older (years) (82.9\u00b15.4 vs 78.1\u00b19.1, p=0.000\u2009and 79.2\u00b18.4 vs 77.6\u00b19.6, p=0.246, respectively), and had a higher forced expiratory volume in 1 s\/forced vital capacity (%) (56.0\u00b18.0 vs 51.3\u00b111.6, p=0.005\u2009and 53.1\u00b111.2 vs 49.5\u00b111.2, p=0.013, respectively), less severe spirometric classification (p=0.008\u2009and p=0.001, respectively), and lower white cell count 10<jats:sup>9<\/jats:sup>\/L (8.8\u00b13.2 vs 11.1\u00b14.9, p=0.009\u2009and 10.3\u00b14.4 vs 11.8\u00b15.3, p=0.017, respectively) than the non-eosinophilia group. The bacteriology of endotracheal aspirates showed that <jats:italic>Pseudomonas aeruginosa<\/jats:italic> and other gram-negative bacilli were the most common organisms in all study groups. Participants with an EP &gt;2% had a shorter ICU length of stay (OR=12.13, p=0.001) than those with an EP \u22642%, while an AEC &gt;300\u2009cells\/\u00b5L was not associated with any in-ICUoutcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The results of this study have significant clinical implications and should be considered when making treatment decisions for the management of patients with COPD and CAP requiring IMV and ICU admission.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2017-020341","type":"journal-article","created":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T09:32:21Z","timestamp":1536658341000},"page":"e020341","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical features, bacteriology of endotracheal aspirates and treatment outcomes of patients with chronic obstructive pulmonary disease and community-acquired pneumonia in an intensive care unit in Taiwan with an emphasis on eosinophilia versus non-eosinophilia: a retrospective case\u2013control study"],"prefix":"10.1136","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9733-5899","authenticated-orcid":false,"given":"Wei-Chang","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan"},{"name":"Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan"},{"name":"Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Hsiao","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, 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