{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:56:30Z","timestamp":1785452190386,"version":"3.56.0"},"reference-count":26,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,2,5]]},"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate cervical regeneration at 6\u2009months following excisional treatment for high-grade cervical intraepithelial neoplasia (CIN), and to investigate the effect of cone dimensions, age of patients and technique of excision on the efficacy of the regeneration process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective observational multicentric study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Three tertiary care and research centres.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Among the 197 eligible women of childbearing age, older than 25 years of age, undergoing for the first time a loop electrosurgical excision procedure or carbon dioxide laser cervical excision for a high-grade CIN at the colposcopy-directed cervical punch biopsy, and with a final diagnosis of high-grade CIN, 165 completed the 6-month follow-up and were included in the analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary outcome measures<\/jats:title>\n                    <jats:p>The cervical length and volume regeneration (%) after 6\u2009months from procedure were determined by three-dimensional ultrasound, and the correlation of regeneration with cone dimensions, age and excision technique was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean\u00b1SD\u2009cervical length regeneration at 6\u2009months was 89.5%\u00b16.3%\u2009and the mean\u00b1SD\u2009cervical volume regeneration was 86.3%\u00b113.2%. At the multivariate analysis, a significant and independent inverse correlation between excised cone length and cervical regeneration emerged (r=\u22120.39, P&lt;0.001). A significantly negative trend in length regeneration at 6\u2009months from procedure with an increasing class of cone length was found (P&lt;0.001). No significant association was found in relation with patient age at the time of procedure or with the technique of excision.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cervical length regeneration at 6\u2009months from excisional treatments is negatively affected by an increasing cone length but not from the age of the patient or the technique of excision. While still achieving equal clinical efficacy, it is crucial to contain cone dimensions, in order to favour a greater length regeneration, reducing the cervical harm and the potential future obstetric complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2017-020675","type":"journal-article","created":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T08:20:36Z","timestamp":1521447636000},"page":"e020675","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Effect of age and cone dimensions on cervical regeneration: an Italian multicentric prospective observational study"],"prefix":"10.1136","volume":"8","author":[{"given":"Andrea","family":"Ciavattini","sequence":"first","affiliation":[{"name":"Woman\u2019s Health Sciences Department, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Delli Carpini","sequence":"additional","affiliation":[{"name":"Woman\u2019s Health Sciences Department, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Moriconi","sequence":"additional","affiliation":[{"name":"Woman\u2019s Health Sciences Department, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00f2","family":"Clemente","sequence":"additional","affiliation":[{"name":"Woman\u2019s Health Sciences Department, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Montik","sequence":"additional","affiliation":[{"name":"Woman\u2019s Health Sciences Department, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"De Vincenzo","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Del Fabro","sequence":"additional","affiliation":[{"name":"Gynecological Oncology Unit, Centro di Riferimento Oncologico - 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