{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:17:28Z","timestamp":1787242648303,"version":"build-2736575974"},"reference-count":41,"publisher":"BMJ","issue":"6","funder":[{"name":"the Projects of the National Natural Science Foundation of China"},{"name":"the Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University"},{"name":"the National Key Research and Development Program"},{"name":"the Science and Technology Planning Project of Guangzhou, China"},{"name":"the Science, Technology and Innovation Committee of Shenzhen"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,5,4]]},"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to evaluate the relation of total homocysteine (tHcy) concentrations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels, and examine the possible modifiers in the association among a general population of Chinese adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>The study was conducted within 21 communities in Lianyungang of Jiangsu province, China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>A total of 26\u2009648 participants aged \u226535 years and with no antihypertensive drug use were included in the final analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, there was a positive association between tHcy concentrations and SBP (per 5 \u03bcmol\/L tHcy increase: adjusted \u03b2=0.45\u2009mm Hg; 95%\u2009CI 0.29 to 0.61) or DBP levels (per 5 \u03bcmol\/L tHcy increase: adjusted \u03b2=0.47\u2009mm Hg; 95%\u2009CI 0.35 to 0.59). Compared with participants with tHcy &lt;10 \u03bcmol\/L, significantly higher SBP levels were found in those with tHcy concentrations of 10 to &lt;15 (adjusted \u03b2=0.80\u2009mm Hg; 95%\u2009CI 0.32 to 1.28) and \u226515 \u00b5mol\/L (adjusted \u03b2=1.79\u2009mm Hg; 95%\u2009CI 1.20 to 2.37; p for trend &lt;0.001). Consistently, significantly higher DBP levels were found in participants with tHcy concentrations of 10 to &lt;15 (adjusted \u03b2=0.86\u2009mm Hg; 95%\u2009CI 0.49 to 1.22) and \u226515 \u00b5mol\/L (adjusted \u03b2=2.01\u2009mm Hg; 95%\u2009CI 1.57 to 2.46; p for trend &lt;0.001), respectively as compared with those with &lt;10 \u03bcmol\/L. Furthermore, a stronger association between tHcy and SBP (p for interaction=0.009) or DBP (p for interaction=0.067) was found in current alcohol drinkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum tHcy concentrations were positively associated with both SBP and DBP levels in a general Chinese adult population. The association was stronger in current alcohol drinkers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2017-021103","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T11:16:37Z","timestamp":1529406997000},"page":"e021103","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["Association of total homocysteine with blood pressure in a general population of Chinese adults: a cross-sectional study in Jiangsu province, China"],"prefix":"10.1136","volume":"8","author":[{"given":"Hongxu","family":"Wu","sequence":"first","affiliation":[{"name":"Institute of Biomedicine, Anhui Medical University, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, Anhui Medical University, Hefei, China"},{"name":"National Clinical Research Center for Kidney Disease, 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