{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:01:54Z","timestamp":1783699314322,"version":"3.55.0"},"reference-count":48,"publisher":"BMJ","issue":"6","funder":[{"DOI":"10.13039\/501100000589","name":"Chief Scientist Office","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000589","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,4,20]]},"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the feasibility of delivering and evaluating a lifestyle programme for patients with colorectal cancer undergoing potentially curative treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Non-randomised feasibility trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>National Health Service (NHS) Tayside.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Adults with stage I\u2013III colorectal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>The programme targeted smoking, alcohol, physical activity, diet and weight management. It was delivered in three face-to-face counselling sessions (plus nine phone calls) by lifestyle coaches over three phases (1: presurgery, 2: surgical recovery and 3: post-treatment recovery).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary outcome<\/jats:title>\n                    <jats:p>Feasibility measures (recruitment, retention, programme implementation, achieved measures, fidelity, factors affecting protocol adherence and acceptability).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Secondary outcomes<\/jats:title>\n                    <jats:p>Measured changes in body weight, waist circumference, walking and self-reported physical activity, diet, smoking, alcohol intake, fatigue, bowel function and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 84 patients diagnosed, 22 (26%) were recruited and 15 (18%) completed the study. Median time for intervention delivery was 5.5\u2009hours. Coaches reported covering most (&gt;70%) of the intervention components but had difficulties during phase 2. Evaluation measures (except walk test) were achieved by all participants at baseline, and most (&lt;90%) at end of phase 2 and phase 3, but &lt;20% at end of phase 1. Protocol challenges included limited time between diagnosis and surgery and the presence of comorbidities. The intervention was rated highly by participants but limited support from NHS staff was noted. The majority of participants (77%) had a body mass index&gt;25\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and none was underweight. Physical activity data showed a positive trend towards increased activity overall, but no other changes in secondary outcomes were detected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>To make this intervention feasible for testing as a full trial, further research is required on (a) recruitment optimisation, (b) appropriate assessment tools, (c) protocols for phase 2 and 3, which can build in flexibility and (d) ways for NHS staff to facilitate the programme.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"ISRCTN52345929\" ext-link-type=\"isrctn\" specific-use=\"clinicaltrial post-results\">ISRCTN52345929<\/jats:ext-link>\n                      ; Post-results.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2017-021117","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T02:15:46Z","timestamp":1528337746000},"page":"e021117","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Feasibility study to assess the delivery of a lifestyle intervention (TreatWELL) for patients with colorectal cancer undergoing potentially curative treatment"],"prefix":"10.1136","volume":"8","clinical-trial-number":[{"clinical-trial-number":"isrctn52345929","registry":"10.18810\/isrctn","type":"postResults"}],"author":[{"given":"Maureen","family":"Macleod","sequence":"first","affiliation":[{"name":"Division of Cancer Research, Centre for Research into Cancer Prevention and Screening, University of Dundee, Dundee, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J C","family":"Steele","sequence":"additional","affiliation":[{"name":"Division of Cancer Research, Centre for Research into Cancer Prevention and Screening, University of Dundee, Dundee, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronan E","family":"O\u2019Carroll","sequence":"additional","affiliation":[{"name":"Division of Psychology, School of Natural Sciences, University of Stirling, Stirling, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5789-2773","authenticated-orcid":false,"given":"Mary","family":"Wells","sequence":"additional","affiliation":[{"name":"NMAHP Research Unit, University of Stirling, Stirling, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Sport Exercise and Health Science, School of Applied Science, Edinburgh Napier University, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqui A","family":"Sugden","sequence":"additional","affiliation":[{"name":"Division of Cancer Research, Centre for Research into Cancer Prevention and Screening, University of Dundee, Dundee, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Rodger","sequence":"additional","affiliation":[{"name":"Division of Cancer Research, Centre for Research into Cancer Prevention and Screening, University of Dundee, Dundee, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Stead","sequence":"additional","affiliation":[{"name":"Institute for Social Marketing, University of Stirling and the Open University, Stirling, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"McKell","sequence":"additional","affiliation":[{"name":"Institute for Social Marketing, University of Stirling and the Open University, Stirling, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie S","family":"Anderson","sequence":"additional","affiliation":[{"name":"Division of Cancer Research, Centre for Research into Cancer Prevention and Screening, University of Dundee, Dundee, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,6,6]]},"reference":[{"key":"2025121602193936000_8.6.e021117.1","unstructured":"The EUROCARE-4 database on cancer survival in Europe. http:\/\/www.eurocare.it\/Results\/tabid\/79\/Default.aspx (accessed Oct 2017)."},{"key":"2025121602193936000_8.6.e021117.2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300563"},{"key":"2025121602193936000_8.6.e021117.3","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-008-9292-9"},{"key":"2025121602193936000_8.6.e021117.4","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-008-9324-2"},{"key":"2025121602193936000_8.6.e021117.5","doi-asserted-by":"crossref","unstructured":"Brandenbarg D , Korsten J , Berger MY , et al . 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