{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T13:17:24Z","timestamp":1778678244375,"version":"3.51.4"},"reference-count":50,"publisher":"BMJ","issue":"7","funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,5,14]]},"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cancer-related fatigue is a frequent symptom in patients with cancer and one of the most distressing symptoms in patients with breast cancer. Sipjeondaebo-tang (Juzen-taiho-to in Japanese or Shi-Quan-Da-Bu-Tang in Chinese) is a widely used herbal medicine for the treatment of fatigue in Korea, China and Japan. The purpose of the present study is to evaluate the feasibility of Sipjeondaebo-tang for cancer-related fatigue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>The present study is a randomised, double-blind, placebo-controlled, cross-over study. Forty-eight patients with breast cancer who are indicated for doxorubicin and cyclophosphamide will be recruited. The participants will receive 3\u2009g of Sipjeondaebo-tang or a placebo three times a day for 56\u2009days. The primary outcome measurement is the change in the Brief Fatigue Inventory scores. The secondary outcome measurements include the changes in the Visual Analogue Scale (VAS) of fatigue, and quality of life measured by the European Organization for Research and Treatment of Cancer\u2014QLQ-C30 and QLQ-BR23. VAS of fatigue will be measured on every visit, and other outcomes will be measured on visits 2, 4, 6 and 7. The total study period is 14\u2009weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This study has been approved by the Institutional Review Board of the Catholic Kwandong University International St Mary\u2019s Hospital (reference IS16MNSI0011). The results of this study will be published in a peer-reviewed journal and presented at a scientific conference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"NCT02858856\" ext-link-type=\"clintrialgov\" specific-use=\"clinicaltrial pre-results\">NCT02858856<\/jats:ext-link>\n                      ; Pre-results.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2017-021242","type":"journal-article","created":{"date-parts":[[2018,7,7]],"date-time":"2018-07-07T03:01:03Z","timestamp":1530932463000},"page":"e021242","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Sipjeondaebo-tang in patients with breast cancer with fatigue: a protocol for a pilot, randomised, double-blind, placebo-controlled, cross-over trial"],"prefix":"10.1136","volume":"8","clinical-trial-number":[{"clinical-trial-number":"nct02858856","registry":"10.18810\/clinical-trials-gov","type":"preResults"}],"author":[{"given":"Chunhoo","family":"Cheon","sequence":"first","affiliation":[{"name":"Department of Korean Preventive Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohyeon","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Korean Preventive Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youme","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Korean Preventive Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Neurologic Disease (Stroke Center), College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Hyoung","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Korean Preventive Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Cheol","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Korean Preventive Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Gyu","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Korean Preventive Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,7,6]]},"reference":[{"key":"2025121221513828000_8.7.e021242.1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27475"},{"key":"2025121221513828000_8.7.e021242.2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2015.0122"},{"key":"2025121221513828000_8.7.e021242.3","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh229"},{"key":"2025121221513828000_8.7.e021242.4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5394.1998.1998006013.x"},{"key":"2025121221513828000_8.7.e021242.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(99)00082-2"},{"key":"2025121221513828000_8.7.e021242.6","first-page":"512","article-title":"The prevalence of fatigue in cancer patients at St","volume":"73","author":"Song","year":"2007","journal-title":"Vincent\u2019s hospital. 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