{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:29:59Z","timestamp":1740162599362,"version":"3.37.3"},"reference-count":8,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,5,21]]},"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To understand the discrepancy between the published 10-year cardiovascular risk and 10-year cardiovascular risk generated from raw data using the Framingham Risk Score for participants in the Systolic Blood Pressure Intervention Trial (SPRINT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Secondary analysis of SPRINT data published in<jats:italic>The New England Journal of Medicine<\/jats:italic>(<jats:italic>NEJM<\/jats:italic>) and made available to researchers in late 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>SPRINT clinical trial sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Study participants enrolled into SPRINT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of SPRINT study participants identified as having \u226515% 10-year cardiovascular risk was not consistent with what was reported in the original publication. Using the data from the trial, the Framingham Risk Score indicated \u226515% 10-year cardiovascular risk for 7089 participants compared with 5737 reported in the paper, a change from 61% to 76% of the total study population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The analysis of the clinical trial data by independent investigators identified an error in the reporting of the risk of the study population. The SPRINT trial enrolled a higher risk population than was reported in the initial publication, which was brought to light by data sharing.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2018-021685","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T07:36:26Z","timestamp":1532331386000},"page":"e021685","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Accurate estimation of cardiovascular risk in a non-diabetic adult: detecting and correcting the error in the reported Framingham Risk Score for the Systolic Blood Pressure Intervention Trial population"],"prefix":"10.1136","volume":"8","author":[{"given":"Frederick","family":"Warner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanket S","family":"Dhruva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph S","family":"Ross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pranammya","family":"Dey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karthik","family":"Murugiah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2046-127X","authenticated-orcid":false,"given":"Harlan M","family":"Krumholz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,7,23]]},"reference":[{"key":"2024051712414156000_8.7.e021685.1","unstructured":"Riley WT , Riddle M , Lauer MS . NIH policies on experimental studies with humans. Nat Hum Behav 2017. https:\/\/www.nature.com\/articles\/s41562-017-0265-4.pdf?origin=ppub"},{"key":"2024051712414156000_8.7.e021685.2","unstructured":"National Heart, Lung, and Blood Institute. Systolic blood pressure intervention trial primary outcome paper (SPRINT-POP) Data. BioLINCC 2016.https:\/\/biolincc.nhlbi.nih.gov\/studies\/sprint_pop\/"},{"key":"2024051712414156000_8.7.e021685.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511939"},{"key":"2024051712414156000_8.7.e021685.4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.699579"},{"key":"2024051712414156000_8.7.e021685.5","unstructured":"Whelton PK , Carey RM , Aronow WS , et al . ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension 2017."},{"key":"2024051712414156000_8.7.e021685.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMx170008"},{"key":"2024051712414156000_8.7.e021685.7","unstructured":"BioLINCC. 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