{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:47:11Z","timestamp":1784357231564,"version":"3.55.0"},"reference-count":33,"publisher":"BMJ","issue":"7","funder":[{"DOI":"10.13039\/501100012446","name":"Akershus University Hospital","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012446","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Vestre Viken Hospital Trust"},{"DOI":"10.13039\/501100013263","name":"Norwegian Health Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013263","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,6,5]]},"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the sex-specific prevalence of atrial fibrillation (AF), including subclinical AF found by screening in a general population aged 63\u201365 years. The prevalence of cardiovascular risk factors and their association with AF will also be investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross-sectional analysis of an observational, prospective, longitudinal, population-based cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>General population in Akershus county, Norway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Women and men born in 1950. We included 3706 of 5827 eligible individuals (63.6%); 48.8% were women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All participants underwent extensive cardiovascular examinations, including 12-lead ECG. History of AF and other cardiovascular diseases were self-reported. Subsequent validation of all reported or detected AF diagnoses was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean age was 63.9\u00b10.7 years. Prevalence of ECG-verified AF was 4.5% (women 2.4%, men 6.4%; p&lt;0.001), including screen-detected AF in 0.3% (women 0.1%, men 0.6%; p&lt;0.01). Hypertension was found in 62.0% (women 57.8%, men 66.0%; p&lt;0.001). Overweight or obesity was found in 67.6% (women 59.8%, men 74.9%; p&lt;0.001). By multivariate logistic regression, risk factors associated with AF were height (OR 1.67 per 10 cm; 95% CI 1.26 to 2.22; p&lt;0.001), weight (OR 1.15 per 10 kg; 95% CI 1.01 to 1.30; p=0.03), hypertension (OR 2.49; 95% CI 1.61 to 3.86; p&lt;0.001), heart failure (OR 3.51; 95% CI 1.71 to 7.24; p=0.001), reduced estimated glomerular filtration rate (OR 2.56; 95% CI 1.42 to 4.60; p&lt;0.01) and at least one first-degree relative with AF (OR 2.32; 95% CI 1.63 to 3.31; p&lt;0.001), whereas male sex was not significantly associated (OR 1.00; 95% CI 0.59 to 1.68; p=0.99).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this cohort from the general population aged 63\u201365 years, we found a higher prevalence of known AF than previously reported below the age of 65 years. The additional yield of single time point screening for AF was low. Body size and comorbidity may explain most of the sex difference in AF prevalence at this age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"NCT01555411\" ext-link-type=\"clintrialgov\" specific-use=\"clinicaltrial results\">NCT01555411<\/jats:ext-link>\n                      ; Results.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-021704","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T11:20:02Z","timestamp":1533122402000},"page":"e021704","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Prevalence of atrial fibrillation and cardiovascular risk factors in a 63\u201365 years old general population cohort: the Akershus Cardiac Examination (ACE) 1950 Study"],"prefix":"10.1136","volume":"8","clinical-trial-number":[{"clinical-trial-number":"nct01555411","registry":"10.18810\/clinical-trials-gov","type":"results"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7681-8621","authenticated-orcid":false,"given":"Trygve","family":"Berge","sequence":"first","affiliation":[{"name":"Department of Medical Research, B\u00e6rum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway"},{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus Nakrem","family":"Lyngbakken","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"Division of Medicine, Akershus University Hospital, Lorenskog, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kon","family":"Ihle-Hansen","sequence":"additional","affiliation":[{"name":"Department of Medical Research, B\u00e6rum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway"},{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Brynildsen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"Division of Medicine, Akershus University Hospital, Lorenskog, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Osman","family":"Pervez","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"Division of Medicine, Akershus University Hospital, Lorenskog, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika Nerdrum","family":"Aagaard","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"Division of Medicine, Akershus University Hospital, Lorenskog, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thea","family":"Vigen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"Division of Medicine, Akershus University Hospital, Lorenskog, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brede","family":"Kvisvik","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"Division of Medicine, Akershus University Hospital, Lorenskog, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid Elisabeth","family":"Christophersen","sequence":"additional","affiliation":[{"name":"Department of Medical Research, B\u00e6rum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjetil","family":"Steine","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"Division of Medicine, Akershus University Hospital, Lorenskog, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torbj\u00f8rn","family":"Omland","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"Division of Medicine, Akershus University Hospital, Lorenskog, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e5l","family":"Smith","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"Division of Medicine, Akershus University Hospital, Lorenskog, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helge","family":"R\u00f8sj\u00f8","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"Division of Medicine, Akershus University Hospital, Lorenskog, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnljot","family":"Tveit","sequence":"additional","affiliation":[{"name":"Department of Medical Research, B\u00e6rum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway"},{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,8,1]]},"reference":[{"key":"2025120523482285000_8.7.e021704.1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S47385"},{"key":"2025120523482285000_8.7.e021704.2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eur194"},{"key":"2025120523482285000_8.7.e021704.3","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12114"},{"key":"2025120523482285000_8.7.e021704.4","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1093\/eurheartj\/ehw210","article-title":"ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS","volume":"2016","author":"Kirchhof","year":"2016","journal-title":"Eur Heart J"},{"key":"2025120523482285000_8.7.e021704.5","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-02-0165"},{"key":"2025120523482285000_8.7.e021704.6","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.000102"},{"key":"2025120523482285000_8.7.e021704.7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009035"},{"key":"2025120523482285000_8.7.e021704.8","first-page":"308","article-title":"Heart and Brain Interactions--the Akershus Cardiac Examination (ACE) 1950 Study Design","volume":"49","author":"Berge","year":"2015","journal-title":"Scand Cardiovasc J"},{"key":"2025120523482285000_8.7.e021704.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198710223171718"},{"key":"2025120523482285000_8.7.e021704.10","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dym217"},{"key":"2025120523482285000_8.7.e021704.11","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"2025120523482285000_8.7.e021704.12","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318216ea50"},{"key":"2025120523482285000_8.7.e021704.13","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.541782.AD"},{"key":"2025120523482285000_8.7.e021704.14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2147\/CLEP.S103346","article-title":"Validation of self-reported and hospital-diagnosed atrial fibrillation: the HUNT study","volume":"8","author":"Malmo","year":"2016","journal-title":"Clin Epidemiol"},{"key":"2025120523482285000_8.7.e021704.15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2012.02519.x"},{"key":"2025120523482285000_8.7.e021704.16","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi825"},{"key":"2025120523482285000_8.7.e021704.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2013.07.015"},{"key":"2025120523482285000_8.7.e021704.18","unstructured":"Nyrnes A . Atrial fibrillation in the troms\u00f8 study 1994-2007 (ph.d. thesis): The Arctic University of Norway, Faculty of Health Sciences, 2016."},{"key":"2025120523482285000_8.7.e021704.19","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39280.660567.55"},{"key":"2025120523482285000_8.7.e021704.20","first-page":"293","article-title":"Atrial fibrillation: its prevalence and risk factor profile in the German general population","volume":"109","author":"Schnabel","year":"2012","journal-title":"Dtsch Arztebl Int"},{"key":"2025120523482285000_8.7.e021704.21","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028845"},{"key":"2025120523482285000_8.7.e021704.22","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.014343"},{"key":"2025120523482285000_8.7.e021704.23","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.026693"},{"key":"2025120523482285000_8.7.e021704.24","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-010745","article-title":"Opportunistic screening of atrial fibrillation by automatic blood pressure measurement in the community","volume":"6","author":"Omboni","year":"2016","journal-title":"BMJ Open"},{"key":"2025120523482285000_8.7.e021704.25","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198204293061703"},{"key":"2025120523482285000_8.7.e021704.26","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028981"},{"key":"2025120523482285000_8.7.e021704.27","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61774-8"},{"key":"2025120523482285000_8.7.e021704.28","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1160\/TH16-11-0825","article-title":"Are cardiovascular risk factors also associated with the incidence of atrial fibrillation? A systematic review and field synopsis of 23 factors in 32 population-based cohorts of 20 million participants","volume":"117","author":"Allan","year":"2017","journal-title":"Thromb Haemost"},{"key":"2025120523482285000_8.7.e021704.29","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwv278"},{"key":"2025120523482285000_8.7.e021704.30","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.309732"},{"key":"2025120523482285000_8.7.e021704.31","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/ng.3843","article-title":"Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation","volume":"49","author":"Christophersen","year":"2017","journal-title":"Nat Genet"},{"key":"2025120523482285000_8.7.e021704.32","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1690"},{"key":"2025120523482285000_8.7.e021704.33","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv269"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2018-021704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:48:35Z","timestamp":1765007315000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2018-021704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":33,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,8,1]]},"published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1136\/bmjopen-2018-021704"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2018-021704","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]}}}