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A bivariate mixed-effects model was conducted to combine sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and area under the summary receiver operating characteristic curve (AUC) between pSWE and TE. A sensitivity analysis was implemented to explore the source of heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Patients with NAFLD who had a liver stiffness measurement using pSWE and TE before liver biopsy were enrolled according to the following criteria: 2\u00d72\u2009contingency tables can be calculated via the reported number of cases; sensitivity and specificity were excluded according to the following criteria: history of other hepatic damage, such as chronic hepatitis C, concurrent active hepatitis B infection, autoimmune hepatitis, suspicious drug usage and alcohol abuse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine pSWE studies comprising a total of 982 patients and 11 TE studies comprising a total of 1753 patients were included. For detection of significant fibrosis, advanced fibrosis and cirrhosis, the summary AUC was 0.86 (95% CI 0.83 to 0.89), 0.94 (95% CI 0.91 to 0.95) and 0.95 (95% CI 0.93 to 0.97) for pSWE, and the summary AUC was 0.85 (95% CI 0.82 to 0.88), 0.92 (95% CI 0.89 to 0.94) and 0.94 (95% CI 0.93 to 0.97) for TE, respectively. The proportion of failure measurement was over tenfold as common with TE using an M probe compared with pSWE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>pSWE and TE, providing precise non-invasive staging of liver fibrosis in NAFLD, are promising techniques, particularly for advanced fibrosis and cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2018-021787","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T11:05:33Z","timestamp":1535022333000},"page":"e021787","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":122,"title":["Diagnostic accuracy of point shear wave elastography and transient elastography for staging hepatic fibrosis in patients with non-alcoholic fatty liver disease: a meta-analysis"],"prefix":"10.1136","volume":"8","author":[{"given":"Weixi","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7017-4570","authenticated-orcid":false,"given":"Haitao","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,8,23]]},"reference":[{"key":"2024051712454716000_8.8.e021787.1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.09.038"},{"key":"2024051712454716000_8.8.e021787.2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300342"},{"key":"2024051712454716000_8.8.e021787.3","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s00535-015-1050-7","article-title":"Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis","volume":"50","author":"Watanabe","year":"2015","journal-title":"J Gastroenterol"},{"key":"2024051712454716000_8.8.e021787.4","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.8.1844"},{"key":"2024051712454716000_8.8.e021787.5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.5370"},{"key":"2024051712454716000_8.8.e021787.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.01.023"},{"key":"2024051712454716000_8.8.e021787.7","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23312"},{"key":"2024051712454716000_8.8.e021787.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.hep.2003.09.022"},{"key":"2024051712454716000_8.8.e021787.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2015.06.013"},{"key":"2024051712454716000_8.8.e021787.10","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22376"},{"key":"2024051712454716000_8.8.e021787.11","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1007\/s00261-014-0137-6","article-title":"Magnetic resonance elastography and acoustic radiation force impulse for staging hepatic fibrosis: a meta-analysis","volume":"40","author":"Guo","year":"2015","journal-title":"Abdom Imaging"},{"key":"2024051712454716000_8.8.e021787.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.09.046"},{"key":"2024051712454716000_8.8.e021787.13","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1055\/s-0043-103952","article-title":"EFSUMB guidelines and recommendations on the clinical use of liver ultrasound elastography, update 2017 (Long Version)","volume":"38","author":"Dietrich","year":"2017","journal-title":"Ultraschall Med"},{"key":"2024051712454716000_8.8.e021787.14","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10100319"},{"key":"2024051712454716000_8.8.e021787.15","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jus.2012.10.002","article-title":"ARFI elastography in patients with chronic autoimmune liver diseases: A preliminary study","volume":"15","author":"Righi","year":"2012","journal-title":"J Ultrasound"},{"key":"2024051712454716000_8.8.e021787.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2007.10.019"},{"key":"2024051712454716000_8.8.e021787.17","doi-asserted-by":"crossref","unstructured":"Li Y Y-S , Huang Z-Z , et al . 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