{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:21:28Z","timestamp":1787656888379,"version":"build-2736575974"},"reference-count":37,"publisher":"BMJ","issue":"10","funder":[{"DOI":"10.13039\/501100008002","name":"Vancouver Coastal Health Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,9,27]]},"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Polycystic ovary syndrome (PCOS) is an endocrine disorder affecting approximately one in seven women who experience androgen excess, menstrual cycle irregularities, frequent anovulation and a tendency for central obesity and insulin resistance. Chronic subclinical inflammation is now recognised as being common in the context of PCOS, which led to the postulation that PCOS may fundamentally be an inflammatory process. This study aimed to: (1) evaluate serum C reactive protein (CRP)\/albumin ratio as a potential predictive biomarker for PCOS; (2) compare the relationship between CRP\/albumin and PCOS to variables classically associated with the syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Case\u2013control study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Adult obstetrics\/gynaecology, endocrinology and outpatient clinics; university hospital in Bahrain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>200 premenopausal women with a diagnosis of PCOS, and 119 ethnically matched eumenorrheic premenopausal women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>CRP\/albumin ratio, anthropometric measures, insulin resistance, androgen excess.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Independent of body mass index (BMI), receiver operating characteristic curve for CRP\/albumin ratio as a selective biomarker for PCOS was 0.865 (95% CI 0.824 to 0.905), which was more sensitive than CRP alone. Binary regression analysis showed that CRP\/albumin ratio outperformed classical correlates, Free Androgen Index and insulin resistance, in predicting PCOS for every BMI category.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CRP\/albumin ratio, a marker for inflammation related to metabolic dysfunction, was found to have a stronger association with PCOS than either androgen excess or insulin resistance. Inflammation is known to be influenced by adiposity, but relative to controls, women with PCOS have higher levels of CRP\/albumin irrespective of BMI. These findings support the view that inflammation plays a central role in the pathophysiology of PCOS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-021860","type":"journal-article","created":{"date-parts":[[2018,10,27]],"date-time":"2018-10-27T05:26:03Z","timestamp":1540617963000},"page":"e021860","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":36,"title":["Assessing C reactive protein\/albumin ratio as a new biomarker for polycystic ovary syndrome: a case\u2013control study of women from Bahraini medical clinics"],"prefix":"10.1136","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7332-2225","authenticated-orcid":false,"given":"Shirin","family":"Kalyan","sequence":"first","affiliation":[{"name":"CeMCOR, Division of Endocrinology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azita","family":"Goshtesabi","sequence":"additional","affiliation":[{"name":"CeMCOR, Division of Endocrinology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameh","family":"Sarray","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain"},{"name":"Faculty of Sciences, El-Manar University, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Joannou","sequence":"additional","affiliation":[{"name":"CeMCOR, Division of Endocrinology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wassim Y","family":"Almawi","sequence":"additional","affiliation":[{"name":"Faculty of Sciences, El-Manar University, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,10,27]]},"reference":[{"key":"2025121510012443000_8.10.e021860.1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S37559"},{"key":"2025121510012443000_8.10.e021860.2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-032046"},{"key":"2025121510012443000_8.10.e021860.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.09.024"},{"key":"2025121510012443000_8.10.e021860.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.06.035"},{"key":"2025121510012443000_8.10.e021860.5","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61644-6"},{"key":"2025121510012443000_8.10.e021860.6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.1.165"},{"key":"2025121510012443000_8.10.e021860.7","doi-asserted-by":"crossref","first-page":"537","DOI":"10.5604\/12321966.1226842","article-title":"Cardiovascular system diseases in patients with polycystic ovary syndrome - 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