{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T13:30:08Z","timestamp":1765891808349,"version":"3.48.0"},"reference-count":40,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,9,7]]},"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>It is believed that Meniere\u2019s disease (MD) is associated with vascular disorders, but few studies have reported the relationship between retinal vascular disorders and MD. We evaluated and compared the retinal vascular calibres in patients with MD with healthy subjects matched for age, sex and vascular risk factors using retinal photographs to explore the association between MD and retinal vascular calibre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>A prospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary referral centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Sixty patients with MD and 62 healthy subjects matched for age, sex and vascular risk factors were enrolled in this study. Twenty-four patients with MD had migraines, and 36 patients with MD did not have migraines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measure<\/jats:title>\n                    <jats:p>Retinal vascular calibres were calculated and compared not only between patients with MD and healthy subjects but also between subgroups of patients with MD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with healthy subjects, patients with MD had a slightly larger retinal artery calibre (126.30\u00b110.45vs 119.61\u00b115.86, p=0.006) and a higher retinal artery\/vein ratio (0.79\u00b10.09vs 0.75\u00b10.10, p=0.005). Among patients with MD, those with migraines had a larger retinal artery calibre (130.73\u00b111.55vs 123.35\u00b18.61, p=0.006) than those without migraines. Moreover, the presence of migraines and the high frequency of vertigo attacks appeared to increase the retinal artery calibre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study suggests that a relationship exists between retinal vascular calibre and MD. Although the pathophysiological relationship between migraine and MD remains unclear, the presence of migraine attacks may aggravate endolymphatic hydrops (EH) and accelerate the outflow of EH in patients with MD. More extensive studies are required to explore the association between retinal vascular calibre and MD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-022069","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:55:27Z","timestamp":1538528127000},"page":"e022069","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Association of Meniere\u2019s disease and retinal vascular calibre: a prospective observational study in China"],"prefix":"10.1136","volume":"8","author":[{"given":"Yixu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, People\u2019s Hospital, Peking University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongxiang","family":"Diao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, People\u2019s Hospital, Peking University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, People\u2019s Hospital, Peking University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, People\u2019s Hospital, Peking University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, People\u2019s Hospital, Peking University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,10,2]]},"reference":[{"key":"2025121605264151000_8.10.e022069.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61161-7"},{"key":"2025121605264151000_8.10.e022069.2","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0000000000000041"},{"key":"2025121605264151000_8.10.e022069.3","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1288\/00005537-198408000-00020","article-title":"Meniere\u2019s disease: a 30-year epidemiologic and clinical study in Rochester, Mn, 1951-1980","volume":"94","author":"Wladislavosky-Waserman","year":"1984","journal-title":"Laryngoscope"},{"key":"2025121605264151000_8.10.e022069.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.06.015"},{"key":"2025121605264151000_8.10.e022069.5","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200402000-00004"},{"key":"2025121605264151000_8.10.e022069.6","first-page":"135","article-title":"Incidence of Meni\u00e8re\u2019s disease in Italy","volume":"12","author":"Celestino","year":"1991","journal-title":"Am J Otol"},{"key":"2025121605264151000_8.10.e022069.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2013.10.015"},{"key":"2025121605264151000_8.10.e022069.8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/3182735","article-title":"The intimate relationship between vestibular migraine and meniere disease: a review of pathogenesis and presentation","volume":"2016","author":"Liu","year":"2016","journal-title":"Behav Neurol"},{"key":"2025121605264151000_8.10.e022069.9","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000036903.22461.39"},{"key":"2025121605264151000_8.10.e022069.10","doi-asserted-by":"publisher","DOI":"10.1080\/00016480701242469"},{"key":"2025121605264151000_8.10.e022069.11","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31825d644a"},{"key":"2025121605264151000_8.10.e022069.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.03.019"},{"key":"2025121605264151000_8.10.e022069.13","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1007\/s00415-016-8364-0","article-title":"Migraine causes retinal and choroidal structural changes: evaluation with ocular coherence tomography","volume":"264","author":"Reggio","year":"2017","journal-title":"J Neurol"},{"key":"2025121605264151000_8.10.e022069.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2003.12.030"},{"key":"2025121605264151000_8.10.e022069.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00503-4"},{"key":"2025121605264151000_8.10.e022069.16","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1212\/CON.0000000000000204","article-title":"The eye and headache","volume":"21","author":"Friedman","year":"2015","journal-title":"Continuum"},{"key":"2025121605264151000_8.10.e022069.17","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1007\/s00417-016-3432-9","article-title":"The relationship of systemic markers of renal function and vascular function with retinal blood vessel responses","volume":"254","author":"Heitmar","year":"2016","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"2025121605264151000_8.10.e022069.18","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s00405-005-0967-5","article-title":"Association of retinal vasculitis (Eales' disease) and Meniere-like vestibulocochlear symptoms","volume":"263","author":"Wagner","year":"2006","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"2025121605264151000_8.10.e022069.19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000027247","article-title":"Branch retinal artery occlusion in a young woman with M\u00e9ni\u00e8re\u2019s disease","volume":"212","author":"Recupero","year":"1998","journal-title":"Ophthalmologica"},{"key":"2025121605264151000_8.10.e022069.20","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70102-8"},{"key":"2025121605264151000_8.10.e022069.21","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"key":"2025121605264151000_8.10.e022069.22","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90525-0"},{"key":"2025121605264151000_8.10.e022069.23","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm221"},{"key":"2025121605264151000_8.10.e022069.24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00364.x"},{"key":"2025121605264151000_8.10.e022069.25","first-page":"355","article-title":"Inner-ear involvement in primary glaucoma","volume":"57","author":"Seth","year":"1978","journal-title":"Ear Nose Throat J"},{"key":"2025121605264151000_8.10.e022069.26","first-page":"172","article-title":"Lack of association between hearing loss and glaucoma","volume":"18","author":"Shapiro","year":"1997","journal-title":"Am J Otol"},{"key":"2025121605264151000_8.10.e022069.27","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0378-5955(97)00201-3","article-title":"Low-frequency masking for detection of endolymphatic hydrops in patients with glaucoma","volume":"116","author":"Kabudwand","year":"1998","journal-title":"Hear Res"},{"key":"2025121605264151000_8.10.e022069.28","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.bjorl.2015.06.003","article-title":"Vestibular migraine: clinical and epidemiological aspects","volume":"82","author":"Morganti","year":"2016","journal-title":"Braz J Otorhinolaryngol"},{"key":"2025121605264151000_8.10.e022069.29","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/S0030-6665(20)30139-0","article-title":"Pathophysiologic theories in the etiology of Meniere\u2019s disease","volume":"30","author":"Gibson","year":"1997","journal-title":"Otolaryngol Clin North Am"},{"key":"2025121605264151000_8.10.e022069.30","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.9.1749"},{"key":"2025121605264151000_8.10.e022069.31","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413498940"},{"key":"2025121605264151000_8.10.e022069.32","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fneur.2015.00012","article-title":"New insights into pathophysiology of vestibular migraine","volume":"6","author":"Espinosa-Sanchez","year":"2015","journal-title":"Front Neurol"},{"key":"2025121605264151000_8.10.e022069.33","doi-asserted-by":"publisher","DOI":"10.1159\/000116670"},{"key":"2025121605264151000_8.10.e022069.34","first-page":"439","article-title":"Changes in retinal vessel diameters in migraine patients during attack-free period","volume":"10","author":"Unlu","year":"2017","journal-title":"Int J Ophthalmol"},{"key":"2025121605264151000_8.10.e022069.35","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22292"},{"key":"2025121605264151000_8.10.e022069.36","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-030212-183717"},{"key":"2025121605264151000_8.10.e022069.37","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1097\/MAO.0b013e31829e83df","article-title":"Endolymphatic hydrops in M\u00e9ni\u00e8re\u2019s disease: cause, consequence, or epiphenomenon?","volume":"34","author":"Foster","year":"2013","journal-title":"Otol Neurotol"},{"issue":"Suppl 1","key":"2025121605264151000_8.10.e022069.38","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00415-015-7930-1","article-title":"What is Meni\u00e8re\u2019s disease? A contemporary re-evaluation of endolymphatic hydrops","volume":"263","author":"G\u00fcrkov","year":"2016","journal-title":"J Neurol"},{"key":"2025121605264151000_8.10.e022069.39","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/00016480701497436","article-title":"A new animal model for M\u00e9ni\u00e8re\u2019s disease","volume":"128","author":"Takumida","year":"2008","journal-title":"Acta Otolaryngol"},{"key":"2025121605264151000_8.10.e022069.40","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(82)80023-9"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2018-022069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T13:26:49Z","timestamp":1765891609000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2018-022069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":40,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,10,2]]},"published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1136\/bmjopen-2018-022069"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2018-022069","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"type":"print","value":"2044-6055"},{"type":"electronic","value":"2044-6055"}],"subject":[],"published":{"date-parts":[[2018,10]]}}}