{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T04:40:33Z","timestamp":1765082433803,"version":"3.46.0"},"reference-count":23,"publisher":"BMJ","issue":"7","funder":[{"DOI":"10.13039\/501100004476","name":"Chinese Center for Disease Control and Prevention","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004476","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Cooperative Agreements from the U.S. Centers for Disease Control and Prevneiton"},{"name":"Intramural Research Program of the National Institutes of Health, National Cancer Institute, and the U.S. Public Health Service of the Department of Health and Human Services"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,6,21]]},"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the feasibility of long-term prospective follow-up and ascertainment of cancer in offspring and mothers from the 1993\u20131995 Chinese Community Intervention Program that provided folic acid supplements before and during early pregnancy to reduce neural tube defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Feasibility pilot study for a prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Families residing during 2012\u20132013 in one rural and one urban county from 21 counties in 3 provinces in China included in the Community Intervention Program campaign.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>The feasibility study targeted 560 families, including 280 from the rural and 280 from the urban county included in the large original study; about half of mothers in each group had taken and half had not taken folic acid supplements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>The planned new study is observational.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>Primary: incidence of paediatric cancers in offspring; secondary: other chronic diseases in offspring and chronic diseases in mothers<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Only 3.4% of pilot study families could not be found, 3.9% had moved out of the study area and 8.8% refused to participate. Interviews were completed by 82% of mothers, 79% of fathers and 83% of offspring in the 560 families. Almost all mothers and offspring who were interviewed also participated in anthropometric measurements. We found notable urban\u2013rural differences in sociodemographic and lifestyle characteristics of the parents, but fewer differences among the offspring. In eight catchment area hospitals, we identified a broad range of paediatric cancers diagnosed during 1994\u20132013, although paediatric brain tumours, lymphomas and rarer cancers were likely under-represented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, 20 years after the original Community Intervention Program, the pilot study achieved high levels of follow-up and family member interview participation, and identified substantial numbers of paediatric malignancies during 1994\u20132013 in catchment area hospitals. Next steps and strategies for overcoming limitations are described.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-022394","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T09:35:28Z","timestamp":1532943328000},"page":"e022394","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Prospective investigation of folic acid supplements before and during early pregnancy and paediatric and adult cancers in the Chinese children and families cohort: a pilot study in a sample of rural and urban families"],"prefix":"10.1136","volume":"8","author":[{"given":"Martha S","family":"Linet","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linhong","family":"Wang","sequence":"additional","affiliation":[{"name":"National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Wang","sequence":"additional","affiliation":[{"name":"National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J","family":"Berry","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Chao","sequence":"additional","affiliation":[{"name":"Center for Global Health, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Hao","sequence":"additional","affiliation":[{"name":"CDC Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhu","family":"Li","sequence":"additional","affiliation":[{"name":"Independent Consultant, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwen","family":"Fang","sequence":"additional","affiliation":[{"name":"National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Yin","sequence":"additional","affiliation":[{"name":"National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Potischman","sequence":"additional","affiliation":[{"name":"Office of Dietary Supplements, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Sun","sequence":"additional","affiliation":[{"name":"National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanweng","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Surgery, Laoting County Maternal and Child Health Hospital, Laoting, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruilan","family":"Yang","sequence":"additional","affiliation":[{"name":"Taicang County Maternal and Child Hospital, Taicang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Cong","sequence":"additional","affiliation":[{"name":"National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Fan","sequence":"additional","affiliation":[{"name":"National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cari M","family":"Kitahara","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Liang","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[{"name":"Center of Pediatric Blood Diseases, Tianjin Hematology Institute and Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Taicang First People\u2019s Hospital, Taicang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Shanghai Xinhua Hospital, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhua","family":"Mu","sequence":"additional","affiliation":[{"name":"Laoting County Hospital, Laoting, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Sampson","sequence":"additional","affiliation":[{"name":"Division of Cancer 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