{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T06:11:43Z","timestamp":1774332703631,"version":"3.50.1"},"reference-count":24,"publisher":"BMJ","issue":"1","funder":[{"name":"French Ministry of Health"},{"name":"French Ministry of Health"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,10,25]]},"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We tested the hypothesis that stroke outcomes in patients with preadmission use of benzodiazepine are worse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In a prospective cohort study, we recruited patients with acute ischaemic stroke. Mortality, functional outcomes and cognition were evaluated at 8 and 90 days after stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>370 patients were included. 62 (18.5%) of the 336 remaining patients were treated with benzodiazepines when stroke occurred, and they did not receive any other psychotropic drug. The mortality rate was higher in benzodiazepines users than non-users at day 8 (2.2% vs 8.1%, p=0.034) and day 90 (8.1% vs 25.9%, p=0.0001). After controlling for baseline differences using propensity-score matching, only the difference in mortality rate at day 90 was of borderline of significance, with a matched OR of 3.93 (95% CI, 0.91 to 16.98). In propensity-score-adjusted cohort, this difference remained significant with a similar treatment effect size (adjusted OR, 3.50; 95%\u2009CI, 1.57 to 7.76). A higher rate of poor functional outcome at day 8 and day 90 defined bymodified Rankin scale (mRS) \u22652\u2009or by theBarthel index (BI) &lt;95 was found in benzodiazepines users. In propensity-score-adjusted cohort, only the difference in mRS\u22652 at day 90 remained significant (adjusted OR, 1.89; 95%\u2009CI, 1.02 to 3.48). In survivors at day 8 and at day 90, there was no significant difference in cognitive evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study has shown that preadmission use of benzodiazepines could be associated with increased post-stroke mortality at 90 days. These findings do not support a putative neuroprotective effect of \u03b3-aminobutyric acid<jats:sub>A<\/jats:sub>receptors agonists and should alert clinicians of their potential risks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration number<\/jats:title><jats:p>NCT00763217.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2018-022720","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T14:50:56Z","timestamp":1547563856000},"page":"e022720","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Preadmission use of benzodiazepines and stroke outcomes: the Biostroke prospective cohort study"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0243-3518","authenticated-orcid":false,"given":"Olivier","family":"Colin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Labreuche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Deguil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Marie","family":"Mendyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Deken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Cordonnier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Deplanque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Leys","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9gis","family":"Bordet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"key":"2024051713215640000_9.1.e022720.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61728-0"},{"key":"2024051713215640000_9.1.e022720.2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000240057.71766.71"},{"key":"2024051713215640000_9.1.e022720.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)02511-3"},{"key":"2024051713215640000_9.1.e022720.4","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/sj.bjp.0703398","article-title":"On the regulation of ischaemia-induced glutamate efflux from rat cortex by GABA; in vitro studies with GABA, clomethiazole and pentobarbitone","volume":"130","author":"Nelson","year":"2000","journal-title":"Br J Pharmacol"},{"key":"2024051713215640000_9.1.e022720.5","first-page":"CD009622","article-title":"Gamma aminobutyric acid (GABA) receptor agonists for acute stroke","volume":"2","author":"Liu","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"2024051713215640000_9.1.e022720.6","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001355"},{"key":"2024051713215640000_9.1.e022720.7","doi-asserted-by":"publisher","DOI":"10.1080\/00273171.2011.568786"},{"key":"2024051713215640000_9.1.e022720.8","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6004"},{"key":"2024051713215640000_9.1.e022720.9","doi-asserted-by":"publisher","DOI":"10.1002\/pst.433"},{"key":"2024051713215640000_9.1.e022720.10","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3697"},{"key":"2024051713215640000_9.1.e022720.11","doi-asserted-by":"publisher","DOI":"10.1007\/s10260-007-0086-0"},{"key":"2024051713215640000_9.1.e022720.12","doi-asserted-by":"crossref","unstructured":"Buuren S , Groothuis-Oudshoorn K . mice : multivariate imputation by chained equations in R . 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