{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:39:52Z","timestamp":1780731592893,"version":"3.54.1"},"reference-count":34,"publisher":"BMJ","issue":"12","funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,10,12]]},"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Fetal growth restriction (FGR) is a relevant research and clinical concern since it is related to higher risks of adverse outcomes at any period of life. Current predictive tools in pregnancy (clinical factors, ultrasound scan, placenta-related biomarkers) fail to identify the true growth-restricted fetus. However, technologies based on metabolomics have generated interesting findings and seem promising. In this systematic review, we will address diagnostic accuracy of metabolomics analyses in predicting FGR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>Our primary outcome is small for gestational age infant, as a surrogate for FGR, defined as birth weight below the 10th centile by customised or population-based curves for gestational age. A detailed systematic literature search will be carried in electronic databases and conference abstracts, using the keywords \u2018fetal growth retardation\u2019, \u2018metabolomics\u2019, \u2018pregnancy\u2019 and \u2018screening\u2019 (and their variations). We will include original peer-reviewed articles published from 1998 to 2018, involving pregnancies of fetuses without congenital malformations; sample collection must have been performed before clinical recognition of growth impairment. If additional information is required, authors will be contacted. Reviews, case reports, cross-sectional studies, non-human research and commentaries papers will be excluded. Sample characteristics and the diagnostic accuracy data will be retrieved and analysed. If data allows, we will perform a meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>As this is a systematic review, no ethical approval is necessary. This protocol will be publicised in our institutional websites and results will be submitted for publication in a peer-reviewed journal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD42018089985.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-022743","type":"journal-article","created":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T04:49:17Z","timestamp":1544158157000},"page":"e022743","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Metabolomics for predicting fetal growth restriction: protocol for a systematic review and meta-analysis"],"prefix":"10.1136","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8839-3934","authenticated-orcid":false,"given":"Debora Farias Batista","family":"Leite","sequence":"first","affiliation":[{"name":"Department of Maternal and Child Health, Clinics Hospital of Federal University of Pernambuco, Recife, Brazil"},{"name":"Department of Gynaecology and Obstetrics, University Campinas, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aude-Claire","family":"Morillon","sequence":"additional","affiliation":[{"name":"Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias F","family":"Melo J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, Clinics Hospital of Federal University of Pernambuco, Recife, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato T","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, University Campinas, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali S","family":"Khashan","sequence":"additional","affiliation":[{"name":"Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, Cork, Ireland"},{"name":"School of Public Health, University College Cork, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip N","family":"Baker","sequence":"additional","affiliation":[{"name":"College of Life Sciences, University of Leicester, Leicester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise C","family":"Kenny","sequence":"additional","affiliation":[{"name":"Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, Cork, Ireland"},{"name":"Department of Women\u2019s and Children\u2019s Health, Faculty of Health and Life Sciences, Institute of Translational Medicine, University of Liverpool, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1285-8445","authenticated-orcid":false,"given":"Jos\u00e9 Guilherme","family":"Cecatti","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, University Campinas, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,12,6]]},"reference":[{"key":"2025121403444167000_8.12.e022743.1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/uog.15884","article-title":"Consensus definition of fetal growth restriction: a Delphi procedure","volume":"48","author":"Gordijn","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"key":"2025121403444167000_8.12.e022743.2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000429658.85846.f9"},{"key":"2025121403444167000_8.12.e022743.3","unstructured":"Medical subject headings. https:\/\/www.ncbi.nlm.nih.gov\/mesh\/68005317 (accessed 23 Jan 2018)."},{"key":"2025121403444167000_8.12.e022743.4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f108"},{"key":"2025121403444167000_8.12.e022743.5","doi-asserted-by":"crossref","first-page":"628.e1","DOI":"10.1016\/j.ajog.2016.06.043","article-title":"Small-for-gestational-age infants among uncomplicated pregnancies at\u00a0term: a secondary analysis of 9 Maternal-Fetal Medicine Units Network\u00a0studies","volume":"215","author":"Mendez-Figueroa","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"2025121403444167000_8.12.e022743.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00131-2"},{"key":"2025121403444167000_8.12.e022743.7","doi-asserted-by":"crossref","unstructured":"Korzeniewski SJ , Allred EN , Joseph RM , et al . 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