{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:41:55Z","timestamp":1785307315763,"version":"3.55.0"},"reference-count":47,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,11,30]]},"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Statins are commonly prescribed worldwide. In addition to being potent lipid-lowering agents, statins have immunomodulating properties that may increase the risk of varicella zoster virus reactivation. This adverse effect may have substantial public health implications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>We performed a meta-analysis of observational studies to assess the association between statin use and the risk of herpes zoster infection. We searched PubMed, Embase, Web of Science and Cochrane databases to identify studies published from 1980 to 2018. The multivariate-adjusted ORs were pooled using random-effect models, and subgroup and sensitivity analyses were performed to examine the source of heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      Six studies were analysed, with a total of more than two million participants. We determined if the use of statins might increase the risk of infection of herpes zoster (OR 1.18, 95% CI 1.11 to 1. 25). We detected significant heterogeneity (I\n                      <jats:sup>2<\/jats:sup>\n                      =91.2%; p&lt;0.000), and determined that the heterogeneity arises from regional differences.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of statins may increase the risk of herpes zoster infection. Because the studies included are limited and there may be potential bias, further studies are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-022897","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T05:13:39Z","timestamp":1550121219000},"page":"e022897","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Association between statin use and herpes zoster: systematic review and meta-analysis"],"prefix":"10.1136","volume":"9","author":[{"given":"Lailai","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Urology, The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqiang","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,2,13]]},"reference":[{"key":"2025121400483495000_9.2.e022897.1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.phrs.2017.04.008","article-title":"Preventing cardiovascular heart disease: Promising nutraceutical and non-nutraceutical treatments for cholesterol management","volume":"120","author":"Johnston","year":"2017","journal-title":"Pharmacol Res"},{"key":"2025121400483495000_9.2.e022897.2","first-page":"483","article-title":"Statins: a new insight into their mechanisms of action and consequent pleiotropic effects","volume":"59","author":"Jasi\u0144ska","year":"2007","journal-title":"Pharmacol Rep"},{"key":"2025121400483495000_9.2.e022897.3","doi-asserted-by":"publisher","DOI":"10.1038\/nri1839"},{"key":"2025121400483495000_9.2.e022897.4","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1212\/WNL.59.7.990","article-title":"Statins as immunomodulators: comparison with interferon-beta 1b in MS","volume":"59","author":"Neuhaus","year":"2002","journal-title":"Neurology"},{"key":"2025121400483495000_9.2.e022897.5","doi-asserted-by":"crossref","unstructured":"Zoster EOH . 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