{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T19:08:00Z","timestamp":1765739280488,"version":"3.48.0"},"reference-count":35,"publisher":"BMJ","issue":"5","funder":[{"name":"Innovation Project of Guangxi Graduate Education"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,11,30]]},"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Erectile dysfunction (ED) affects up to 53.4% of men aged 30\u201380 years. In this study, we aimed to examine the association between homocysteine (HCY), vitamin B\n                      <jats:sub>12<\/jats:sub>\n                      (B12), folic acid (FA) and ED.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Guangxi, China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>A total of 1381 participants who completed questionnaires were included, between September 2009 and December 2009.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measures<\/jats:title>\n                    <jats:p>ED was evaluated by the International Index of Erectile Function scores. Also, the values of HCY, B12 and FA were acquired. Then, regression and between-group analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No association between FA and ED was found. Significant correlations between HCY and ED were found\u2014the relationships between these two parameters were most notable in men aged over 60 years and in men living alone (bachelors or bachelorhood). B12 levels were higher in men with ED (718.53\u00b1234.37\u2009pg\/mL vs 688.74\u00b1229.68, p=0.015). Using multinomial logistic regression analyses, B12 levels were related to mild ED (multivariate adjusted analysis: OR 1.620, 95%\u2009CI 1.141 to 2.300, p=0.007), especially among men aged 40\u201349 years (OR 2.907, 95%\u2009CI 1.402 to 6.026, p=0.004).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We report, for the first time, a relationship between B12 levels and ED. We also found specific cohorts of men for whom the relationship between HCY levels and ED is most prominent. Further studies are required to elucidate the mechanisms underlying these relationships\u2014these may ultimately result in new therapies for ED.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-023003","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T08:31:54Z","timestamp":1558600314000},"page":"e023003","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Association between homocysteine, vitamin B\n                    <sub>\n                      <sub>12<\/sub>\n                    <\/sub>\n                    , folic acid and erectile dysfunction: a cross-sectional study in China"],"prefix":"10.1136","volume":"9","author":[{"given":"Yang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China"},{"name":"Center for Genomicand Personalized Medicine, Guangxi 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