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This trial, therefore, aims to investigate the cortical and biomechanical processes associated with more sport-related and injury-related movements in ACL-reconstructed individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and analysis<\/jats:title><jats:p>ACL-reconstructed participants and uninjured controls will perform repetitive countermovement jumps with single leg landings. Two different conditions are to be completed: anticipated (n=35) versus unanticipated (n=35) successful landings. Under the anticipated condition, participants receive the visual information depicting the requested landing leg prior to the jump. In the unanticipated condition, this information will be provided only about 400 msec prior to landing. Neural correlates of motor planning will be measured using electroencephalography. In detail, movement-related cortical potentials, frequency spectral power and functional connectivity will be assessed. Biomechanical landing quality will be captured via a capacitive force plate. Calculated parameters encompass time to stabilisation, vertical peak ground reaction force, and centre of pressure path length. Potential systematic differences between ACL-reconstructed individuals and controls will be identified in dependence of jumping condition (anticipated\/ unanticipated, injured\/uninjured leg and controls) by using interference statistics. Potential associations between the cortical and biomechanical measures will be calculated by means of correlation analysis. In case of statistical significance (\u03b1&lt;0.05.) further confounders (cofactors) will be considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ethics and dissemination<\/jats:title><jats:p>The independent Ethics Committee of the University of Frankfurt (Faculty of Psychology and Sports Sciences) approved the study. Publications in peer-reviewed journals are planned. The findings will be presented at scientific conferences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial status<\/jats:title><jats:p>At the time of submission of this manuscript, recruitment is ongoing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration number<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"NCT03336060\" ext-link-type=\"clintrialgov\" specific-use=\"clinicaltrial pre-results\">NCT03336060<\/jats:ext-link>; Pre-results.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2018-023048","type":"journal-article","created":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T14:55:49Z","timestamp":1537455349000},"page":"e023048","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Neurophysiological correlates of motor planning and movement initiation in ACL-reconstructed individuals: a case\u2013control study"],"prefix":"10.1136","volume":"8","clinical-trial-number":[{"clinical-trial-number":"nct03336060","registry":"10.18810\/clinical-trials-gov","type":"preResults"},{"clinical-trial-number":"nct03336060","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Florian","family":"Giesche","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Engeroff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Wilke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Niederer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfried","family":"Banzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,9,19]]},"reference":[{"key":"2024051713335609000_8.9.e023048.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ptsp.2004.02.003"},{"key":"2024051713335609000_8.9.e023048.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0804745"},{"key":"2024051713335609000_8.9.e023048.3","doi-asserted-by":"publisher","DOI":"10.4085\/1062-6050-48.6.03."},{"key":"2024051713335609000_8.9.e023048.4","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.1999.29.7.400"},{"key":"2024051713335609000_8.9.e023048.5","doi-asserted-by":"crossref","unstructured":"Khan T , Alvand A , Prieto-Alhambra D , et al . 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