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This study used a large Swedish survey to prospectively examine the effects of work schedule on registry-based antidepressant prescriptions in females and males over a 2-year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was based on an approximately representative sample (n=3980 males, 4663 females) of gainfully employed participants in the Swedish Longitudinal Occupational Survey of Health. Sex-stratified analyses were conducted using logistic regression. For exposure, eight categories described work schedule in 2008: \u2018regular days\u2019 (three categories of night work history: none, \u22643 years, 4+ years), \u2018night shift work\u2019, \u2018regular shift work (no nights)\u2019, \u2018rostered work (no nights)\u2019, \u2018flexible\/non-regulated hours\u2019 and \u2018other\u2019. For the primary outcome measure, all prescriptions coded N06A according to the Anatomical Therapeutic Chemical System were obtained from the Swedish National Prescribed Drug Register and dichotomised into \u2018any\u2019 or \u2018no\u2019 prescriptions between 2008 and 2010. Estimates were adjusted for potential sociodemographic, health and work confounders, and for prior depressive symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 2008, 22% of females versus 19% of males worked outside of regular daytime schedule. Registered antidepressant prescription rates in the postsurvey period were 11.4% for females versus 5.8% for males. In fully adjusted models, females in \u2018flexible\/non-regulated\u2019 schedules showed an increased OR for prospective antidepressant prescriptions (OR=2.01, 95% CI=1.08 to 3.76). In males, odds ratios were most increased in those working \u2018other\u2019 schedules (OR=1.72, 95% CI=0.75 to 3.94) and \u2018Regular days with four or more years\u2019 history of night work\u2019 (OR=1.54, 95% CI=0.93 to 2.56).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study\u2019s findings support a relationship between work schedule and prospective antidepressant prescriptions in the Swedish workforce. Future research should continue to assess sex-stratified relationships, using detailed shift work exposure categories and objective registry data where possible.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2018-023247","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T09:26:08Z","timestamp":1547803568000},"page":"e023247","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of work schedule on prospective antidepressant prescriptions in Sweden: a 2-year sex-stratified analysis using national drug registry data"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1502-2694","authenticated-orcid":false,"given":"Amy L","family":"Hall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"Kecklund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constanze","family":"Leineweber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Tucker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,1,17]]},"reference":[{"key":"2024051713421763000_9.1.e023247.1","doi-asserted-by":"publisher","DOI":"10.1186\/s40557-015-0081-0"},{"key":"2024051713421763000_9.1.e023247.2","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.1344"},{"key":"2024051713421763000_9.1.e023247.3","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.3158"},{"key":"2024051713421763000_9.1.e023247.4","doi-asserted-by":"publisher","DOI":"10.1080\/02678370412331320044"},{"key":"2024051713421763000_9.1.e023247.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.02.019"},{"key":"2024051713421763000_9.1.e023247.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2006.07.001"},{"key":"2024051713421763000_9.1.e023247.7","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.2900"},{"key":"2024051713421763000_9.1.e023247.8","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/23.8.1d"},{"key":"2024051713421763000_9.1.e023247.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsmc.2009.03.001"},{"key":"2024051713421763000_9.1.e023247.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.07.028"},{"key":"2024051713421763000_9.1.e023247.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2011.09.002"},{"key":"2024051713421763000_9.1.e023247.12","doi-asserted-by":"publisher","DOI":"10.1038\/nature11673"},{"key":"2024051713421763000_9.1.e023247.13","doi-asserted-by":"publisher","DOI":"10.1080\/15622970600571822"},{"key":"2024051713421763000_9.1.e023247.14","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291712001511"},{"key":"2024051713421763000_9.1.e023247.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2005.04.008"},{"key":"2024051713421763000_9.1.e023247.16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001547"},{"key":"2024051713421763000_9.1.e023247.17","doi-asserted-by":"publisher","DOI":"10.1081\/CBI-200038525"},{"key":"2024051713421763000_9.1.e023247.18","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.10324"},{"key":"2024051713421763000_9.1.e023247.19","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/annweh\/wxx103","article-title":"Examining exposure assessment in shift work research: a study on depression among nurses","volume":"62","author":"Hall","year":"2018","journal-title":"Ann Work Expo Health"},{"key":"2024051713421763000_9.1.e023247.20","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/S0140-6736(16)00687-5","article-title":"The health crisis of mental health stigma","volume":"387","author":"The Lancet","year":"2016","journal-title":"Lancet"},{"key":"2024051713421763000_9.1.e023247.21","unstructured":"Williams C . 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