{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:36:51Z","timestamp":1787960211436,"version":"build-2784847793"},"reference-count":16,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,10,4]]},"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine if the estimated glomerular filtration rate (eGFR) slope over a 5-year period is related to incident cardiovascular (CV) events in the following 5 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Primary care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>All patients aged \u226550\u2009years with at least four eGFR measurements between 01 January 2006 and 31 December 2010 were included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcome measures<\/jats:title><jats:p>During the follow-up period (01 January 2011 until 31 December 2015), CV events (acute myocardial infarction, stroke (cerebrovascular accident (CVA)\/transient ischemic attack (TIA)), peripheral arterial disease and acute heart failure) were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The slope was calculated by the least square method (in mL\/min\/year). The following slope categories were considered: (\u22121 to 1), (\u22123 to \u22121) (\u22125 to \u22123), \u2264\u22125, (1 to 3), (3 to 5) and \u22655.00\u2009mL\/min\/year. Cox proportional hazards model was used to assess the association between eGFR slope and incidence of CV events. Survival probability from CV events was estimated per slope category.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>19\u2009567 patients had at least four eGFR measurements, of whom 52% was female. 12% of the \u2264\u22125 slope category developed a new CV event in comparison to 7.8% of the reference group and 5.4% of the \u22655\u2009slope category. Survival rates were worst in those with a slope \u2264\u22125. Patients with a slope of (\u22125 to \u22123) and \u2264\u22125 had an adjusted HR of 1.37 and 1.55, respectively. Most patients with a slope &lt;\u22123\u2009mL\/min had an eGFR still &gt;60\u2009mL\/min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Negative eGFR slopes of at least 3\u2009mL\/min\/year give irrespectively of the eGFR itself a higher risk of CV events compared with patient groups with stable or improved kidney function. So the eGFR slope identifies an easy to define group of patients with a high risk for developing CV events.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2018-023594","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T08:56:27Z","timestamp":1542012987000},"page":"e023594","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Is there a correlation between an eGFR slope measured over a 5-year period and incident cardiovascular events in the following 5 years among a Flemish general practice population: a retrospective cohort study"],"prefix":"10.1136","volume":"8","author":[{"given":"Gijs","family":"Van Pottelbergh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavlos","family":"Mamouris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nele","family":"Opdeweegh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Vaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Goderis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Van Den Akker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"key":"2024051713564456000_8.11.e023594.1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2010.05.002"},{"key":"2024051713564456000_8.11.e023594.2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afr154"},{"key":"2024051713564456000_8.11.e023594.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe048236"},{"key":"2024051713564456000_8.11.e023594.4","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr659"},{"key":"2024051713564456000_8.11.e023594.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041031"},{"key":"2024051713564456000_8.11.e023594.6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00838.x"},{"key":"2024051713564456000_8.11.e023594.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041365"},{"key":"2024051713564456000_8.11.e023594.8","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009050546"},{"key":"2024051713564456000_8.11.e023594.9","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr599"},{"key":"2024051713564456000_8.11.e023594.10","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-007571","article-title":"The correlation between blood pressure and kidney function decline in older people: a registry-based cohort study","volume":"5","author":"Vaes","year":"2015","journal-title":"BMJ Open"},{"key":"2024051713564456000_8.11.e023594.11","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-13-61"},{"key":"2024051713564456000_8.11.e023594.12","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015060688"},{"key":"2024051713564456000_8.11.e023594.13","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.443"},{"key":"2024051713564456000_8.11.e023594.14","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009010025"},{"key":"2024051713564456000_8.11.e023594.15","unstructured":"Truyers C , Steven E , Goderis G , et al . 20 jaar Huisartspraktijk in Vlaanderen: Acco, 2015."},{"key":"2024051713564456000_8.11.e023594.16","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.ijcard.2015.09.090","article-title":"Magnitude of rate of change in kidney function and future risk of cardiovascular events","volume":"202","author":"Turin","year":"2016","journal-title":"Int J Cardiol"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2018-023594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T19:59:42Z","timestamp":1715975982000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2018-023594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":16,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,11,12]]},"published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1136\/bmjopen-2018-023594"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2018-023594","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11]]}}}