{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T17:34:19Z","timestamp":1783186459769,"version":"3.54.6"},"reference-count":20,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,12,21]]},"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare pregnancy outcomes in patients with early versus usual gestational diabetes mellitus (GDM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Settings<\/jats:title><jats:p>The Women\u2019s Hospital, Hamad Medical Corporation, Qatar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>GDM women who attended and delivered in the Women\u2019s Hospital, between January and December 2016. GDM was diagnosed based on the 2013-WHO criteria. The study included 801 patients; of which, 273 E-GDM and 528 U-GDM. Early GDM (E-GDM) and usual GDM (U-GDM) were defined as GDM detected before and after 24 weeks\u2019 gestation, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcomes<\/jats:title><jats:p>Maternal and neonatal outcomes and the impact of timing of GDM-diagnosis on pregnancy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At conception, E-GDM women were older (mean age 33.5\u00b15.4 vs 32.0\u00b15.4 years, p&lt;0.001) and had higher body mass index (33.0\u00b16.3 vs 31.7\u00b16.1\u2009kg\/m<jats:sup>2<\/jats:sup>, p=0.0059) compared with U-GDM. The mean fasting, and 1-hour blood glucose levels were significantly higher in E-GDM vs U-GDM, respectively (5.3\u00b10.7 vs 4.0\u00b10.7\u2009mmol\/L, p&lt;0.001\u2009and 10.6\u00b11.7 vs 10.3\u00b11.6\u2009mmol\/L, p&lt;0.001). More patients in the U-GDM were managed on diet alone compared with E-GDM (53.6% vs 27.5%, p&lt;0.001). E-GDM subjects gained less weight per week compared with U-GDM (0.02\u00b10.03 vs 0.12\u00b10.03\u2009kg\/week, p=0.0274). Maternal outcomes were similar between the two groups apart from a higher incidence of preterm labour (25.5% vs 14.4%; p&lt;0.001) and caesarean section (52.4% vs 42.8%; p=0.01) in E-GDM vs U-GDM, respectively. After correction for covariates; gestational age at which GDM was diagnosed was associated with increased risk of macrosomia (OR 1.06, 95%\u2009CI 1.00 to 1.11; p&lt;0.05) and neonatal hypoglycaemia (OR 1.05, 95%\u2009CI 1.00 to 1.11; p&lt;0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data support the concept of early screening and treatment of GDM in high-risk patients. More data are needed to examine the optimal time for screening.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2018-023612","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T10:25:48Z","timestamp":1549448748000},"page":"e023612","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":48,"title":["Pregnancy outcomes of early detected gestational diabetes: a retrospective comparison cohort study, Qatar"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3096-2641","authenticated-orcid":false,"given":"Mohammed","family":"Bashir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Baagar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad","family":"Naem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Elkhatib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor","family":"Alshaybani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin C","family":"Konje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul-Badi","family":"Abou-Samra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,2,5]]},"reference":[{"key":"2024051713574532000_9.2.e023612.1","unstructured":"World Health Organization. Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy. http:\/\/apps.who.int\/iris\/bitstream\/10665\/85975\/1\/WHO_NMH_MND_13.2_eng.pdf (Accessed 30 Jan 2018)."},{"key":"2024051713574532000_9.2.e023612.2","first-page":"S8","article-title":"2. Classification and diagnosis of diabetes","volume":"38","author":"ADA","year":"2014","journal-title":"Diabetes Care"},{"key":"2024051713574532000_9.2.e023612.3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2465"},{"key":"2024051713574532000_9.2.e023612.4","unstructured":"NICE guideline. 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