{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:14:00Z","timestamp":1791933240123,"version":"4.3.4"},"reference-count":23,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,11,14]]},"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To estimate the incidence and epidemiology of catheter-related bloodstream infections (CRBSIs) on a national scale by using prospective epidemiological data from the Swiss <jats:italic>Antibiotic Resistance Surveillance System<\/jats:italic> (ANRESIS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Observational study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>National surveillance from 2008 to 2015 of acute hospitals in Switzerland.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>We included acute Swiss hospitals that sent blood cultures and catheter tip culture results on a regular basis during the entire study period to the ANRESIS database.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Outcome measure<\/jats:title>\n                  <jats:p>A catheter-related bloodstream infection (termed \u2018modified CRBSI\u2019, mCRBSI) was defined as isolating the same microorganism with identical antibiogram from \u22651\u2009blood cultures (performed \u00b17 days around the catheter removal) as the one recovered from the catheter tip. Incidence rates of mCRBSI were calculated per 1000 admissions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>From 2008 to 2015, the mCRBSI incidence rate decreased from 0.83 to 0.58 episodes\/1000 admissions (\u22126% per year, p&lt;0.001). Coagulase-negative staphylococci, <jats:italic>Staphylococcus aureus<\/jats:italic> and fungi all exhibited decreasing trends, while rates of enterococci and Gram-negative bacteria remained stable.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The overall incidence of mCRBSI in Switzerland is decreasing; however, the incidence of mCRBSI due to Enterococci and Gram-negative micro-organisms did not change over time. These pathogens may grow in importance in catheter-related infections, which would have clinical implications for the choice of empirical treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-023824","type":"journal-article","created":{"date-parts":[[2018,12,22]],"date-time":"2018-12-22T09:05:21Z","timestamp":1545469521000},"page":"e023824","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Catheter-related infections: does the spectrum of microbial causes change over time? 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