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The primary aim of this prospective cohort study is to investigate the impact of fibre, red meat and processed meat on risk of late-onset CID, with the perspective that results of this study can contribute in supporting future diet recommendations for effective personalised prevention.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>The study will use data from 57\u2009053 persons from the prospective Danish cohort study \u2018Diet, Cancer and Health\u2019 together with National Health Registry data. The follow-up period is from December 1993 to December 2018. Questionnaire data on diet and lifestyle were collected at entry to the Diet, Cancer and Health study. The outcome CID is defined as having a diagnosis of one of the CIDs registered in the National Patient Registry or, for multiple sclerosis, in the Danish Multiple Sclerosis Registry during follow-up and being treated with a drug used for the specific disease. The major outcome of the analyses will be to detect variability in risk of late onset of any CID and, if power allows, disease risk of late onset of each CID diagnosis between persons with different fibre and red meat, and processed meat intake. The outcome will be adjusted for age, sex, body mass index, physical activity, energy, alcohol, fermented dairy products, education, smoking status, hormone replacement therapy and comorbidity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Ethics and dissemination<\/jats:title>\n                  <jats:p>The study is approved by the Danish Data Protection Agency (2012-58-0018). The core study is an open register-based cohort study. The study does not need approval from the Ethics committee or Institutional Review Board by Danish law. Study findings will be disseminated through peer-reviewed journals, patient associations and presentations at international conferences.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>NCT03456206; Post-results.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-024555","type":"journal-article","created":{"date-parts":[[2019,3,30]],"date-time":"2019-03-30T10:55:34Z","timestamp":1553943334000},"page":"e024555","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Impact of red meat, processed meat and fibre intake on risk of late-onset chronic inflammatory diseases: prospective cohort study on lifestyle factors using the Danish \u2018Diet, Cancer and Health\u2019 cohort (PROCID-DCH): <i>protocol<\/i>"],"prefix":"10.1136","volume":"9","author":[{"given":"Nathalie Fogh","family":"Rasmussen","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, Aarhus University, Aarhus, Denmark"},{"name":"Focused Research Unit for Molecular Diagnostic and Clinical Research, IRS-Center Sonderjylland, Hospital of Southern Jutland, Aabenraa, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrine Hass","family":"Rubin","sequence":"additional","affiliation":[{"name":"OPEN - Odense Patient Data Explorative Network, Department of Clinical Research, University of Southern Denmark, and Odense University Hospital, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Stougaard","sequence":"additional","affiliation":[{"name":"OPEN - Odense Patient Data Explorative Network, Department of Clinical Research, University of Southern Denmark, and Odense University Hospital, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Tj\u00f8nneland","sequence":"additional","affiliation":[{"name":"Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen \u00d8, Denmark\/Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egon","family":"Stenager","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research, University of Southern Denmark, Odense, Denmark"},{"name":"The Multiple Sclerosis Clinic of Southern Jutland (Sonderborg, Kolding, Esbjerg), Department of Neurology, Hospital of Southern Jutland, Sonderborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merete","family":"Lund Hetland","sequence":"additional","affiliation":[{"name":"DANBIO Registry\/Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet Glostrup, Glostrup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bente","family":"Glintborg","sequence":"additional","affiliation":[{"name":"DANBIO Registry\/Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet Glostrup, Glostrup, Denmark"},{"name":"Department of Rheumatology, Gentofte Hospital, Hellerup, Hovedstaden, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anette","family":"Bygum","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre, Odense Universitetshospital, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0127-2863","authenticated-orcid":false,"given":"Vibeke","family":"Andersen","sequence":"additional","affiliation":[{"name":"Focused Research Unit for Molecular Diagnostic and Clinical Research, Hospital of Southern Jutland, Aabenraa, Denmark"},{"name":"institute og molecular medicine, Syddansk Universitet Det Sundhedsvidenskabelige Fakultet, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,3,30]]},"reference":[{"key":"2025101812355844000_9.3.e024555.1","doi-asserted-by":"crossref","unstructured":"Amato MP , Derfuss T , Hemmer B , et al . 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