{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T10:50:27Z","timestamp":1783335027279,"version":"3.54.6"},"reference-count":26,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,11,20]]},"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective was to evaluate the association between age-related comorbidities (ARCs) and 5-year HIV-related excess mortality in people living with HIV aged \u226560 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cohort study using relative survival analysis (Est\u00e8ve\u2019s model).<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>The French multicentre prospective Dat\u2019AIDS cohort that involves 12 French hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Inclusion of 1415 HIV-1 infected patients actively followed aged \u226560 years on January 2008, with a 5-year follow-up period in the late combination antiretroviral therapy era.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1415 patients included, 154 died. By multivariable analysis, factors predictive of 5-year HIV-related excess mortality were non-AIDS-related cancer (adjusted excess HR (aEHR)=2.94; 95% CI 1.32 to 6.57), cardiovascular disease (aEHR=6.00; 95%\u2009CI 2.45 to 14.65), chronic renal disease (aEHR=4.86; 95%\u2009CI 2.24 to 10.53), cirrhosis (aEHR=3.58; 95%\u2009CI 1.25 to 10.28), hepatitis C co-infection (aEHR=3.63; 95%\u2009CI 1.44 to 9.12), body mass index&lt;18.5\u2009kg\/m\u00b2 (aEHR=4.10; 95%\u2009CI 1.61 to 10.48) and having a CD4 cell count \u2264200\/mm<jats:sup>3<\/jats:sup>(aEHR=5.79; 95%\u2009CI 2.28 to 14.69).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ARCs, particularly cardiovascular disease and chronic renal disease, are predictive of HIV-related excess mortality, with an increase in hazard similar to that of CD4 cell count.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration number<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"NCT02898987\" ext-link-type=\"clintrialgov\" specific-use=\"clinicaltrial results\">NCT02898987<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2018-024841","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T20:35:37Z","timestamp":1548448537000},"page":"e024841","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["HIV-related excess mortality and age-related comorbidities in patients with HIV aged \u226560: a relative survival analysis in the French Dat\u2019AIDS cohort"],"prefix":"10.1136","volume":"9","clinical-trial-number":[{"clinical-trial-number":"nct02898987","registry":"10.18810\/clinical-trials-gov","type":"results"},{"clinical-trial-number":"nct02898987","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct02898987","registry":"10.18810\/clinical-trials-gov","type":"results"},{"clinical-trial-number":"nct02898987","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Maxime","family":"Hentzien","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moustapha","family":"Dram\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrille","family":"Delpierre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clotilde","family":"Allavena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Cabi\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Cuzin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Pugliese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"H\u00e9delin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firouz\u00e9","family":"Bani-Sadr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,1,25]]},"reference":[{"key":"2024051714513535000_9.1.e024841.1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-251"},{"key":"2024051714513535000_9.1.e024841.2","unstructured":"Retour d\u2019Informations Clinico-Epid\u00e9miologiques (RICE) - f\u00e9vrier. 2013 http:\/\/www.ccde.fr\/_fold\/fl-1364308704-649.pdf (Accessed 24 Jun 2016)."},{"key":"2024051714513535000_9.1.e024841.3","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir627"},{"key":"2024051714513535000_9.1.e024841.4","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1007\/s12603-015-0608-7","article-title":"Impact of age-related comorbidities on five-year overall mortality among elderly hiv-infected patients in the late haart era-role of chronic renal disease","volume":"20","author":"Hentzien","year":"2016","journal-title":"J Nutr Health Aging"},{"key":"2024051714513535000_9.1.e024841.5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0195725","article-title":"Derivation and internal validation of a mortality risk index for aged people living with HIV: The Dat\u2019AIDS score","volume":"13","author":"Hentzien","year":"2018","journal-title":"PLoS One"},{"key":"2024051714513535000_9.1.e024841.6","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000222"},{"key":"2024051714513535000_9.1.e024841.7","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201006-0836OC"},{"key":"2024051714513535000_9.1.e024841.8","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-1079"},{"key":"2024051714513535000_9.1.e024841.9","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn079"},{"key":"2024051714513535000_9.1.e024841.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2006.01677.x"},{"key":"2024051714513535000_9.1.e024841.11","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2656"},{"key":"2024051714513535000_9.1.e024841.12","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780090506"},{"key":"2024051714513535000_9.1.e024841.13","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1089\/aid.2011.0377","article-title":"Definition of advanced age in HIV infection: looking for an age cut-off","volume":"28","author":"Blanco","year":"2012","journal-title":"AIDS Res Hum Retroviruses"},{"key":"2024051714513535000_9.1.e024841.14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.8431"},{"key":"2024051714513535000_9.1.e024841.15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2009.00719.x"},{"key":"2024051714513535000_9.1.e024841.16","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq433"},{"key":"2024051714513535000_9.1.e024841.17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2008.00686.x"},{"key":"2024051714513535000_9.1.e024841.18","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/62.12.1389"},{"key":"2024051714513535000_9.1.e024841.19","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu701"},{"key":"2024051714513535000_9.1.e024841.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.05.045"},{"key":"2024051714513535000_9.1.e024841.21","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw082"},{"key":"2024051714513535000_9.1.e024841.22","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.5967"},{"key":"2024051714513535000_9.1.e024841.23","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000004890","article-title":"Long-term efficacy and toxicity of abacavir\/lamivudine\/nevirapine compared to the most prescribed ARV regimens before 2013 in a French Nationwide Cohort Study","volume":"95","author":"de Boissieu","year":"2016","journal-title":"Medicine"},{"key":"2024051714513535000_9.1.e024841.24","unstructured":"France,Minist\u00e8re des affaires sociales et de la sant\u00e9 (2012-.), MorlatP. Prise en charge m\u00e9dicale des personnes vivant avec le VIH Rapport2013: recommandations du groupe d\u2019experts. Paris: DILA - Direction de l\u2019information l\u00e9gale et administrative\u202f: La documentation fran\u00e7aise, 2013."},{"key":"2024051714513535000_9.1.e024841.25","doi-asserted-by":"publisher","DOI":"10.1136\/jech.51.3.289"},{"key":"2024051714513535000_9.1.e024841.26","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.1.51"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2018-024841","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T01:52:18Z","timestamp":1715997138000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2018-024841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1136\/bmjopen-2018-024841"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2018-024841","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]}}}