{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T02:39:04Z","timestamp":1784860744305,"version":"3.55.0"},"reference-count":32,"publisher":"BMJ","issue":"3","funder":[{"name":"Instituto de Salud Carlos III, Spain"},{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,1,9]]},"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To assess the prevalence of extended-spectrum beta-lactamase (ESBL)-producing <jats:italic>Enterobacteriaceae<\/jats:italic> (ESBL-E) faecal carriers at admission in a University Hospital in Spain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Prevalence survey.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Pneumology, gastroenterology, urology and neurosurgery units at a university tertiary hospital in Madrid (Spain).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>A total of 10\u2009643 patients aged 18 and older admitted from March 2014 to April 2016 with a rectal swab taken at admission or as soon as possible within the first 48\u2009hours.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Primary and secondary outcome measures<\/jats:title>\n                  <jats:p>Prevalence of ESBL-E faecal carriers and prevalence of ESBL-E infections at admission.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The prevalance of ESBL-E carriers at admission was 7.69% (CI 95% 7.18 to 8.19). Most of the isolates were <jats:italic>Escherichia coli<\/jats:italic> (77.51%), followed by <jats:italic>Klebsiella pneumoniae<\/jats:italic> (20.71%). Eighty-eight (10.41%) of ESBL-E were simultaneous ESBL and carbapenemase (CP) producers, 1.83% in the case of <jats:italic>E. coli<\/jats:italic> and 42.86% among <jats:italic>K. pneumoniae<\/jats:italic> isolates. Of the ESBL typed, 52.15% belonged to the cefotaximases (CTX-M-15) type and 91.38% of the CP were oxacillinase (OXA-48) type. Only 0.43% patients presented an active infection by ESBL-E at admission.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The prevalence found in our study is very similar to that found in literature. However, we found a high percentage of simultaneous ESBL and CP producers, particularly in <jats:italic>K. pneumoniae<\/jats:italic>. Despite the high prevalence of colonised patients, the ESBL-infection rate at admission was very low.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-024879","type":"journal-article","created":{"date-parts":[[2019,3,2]],"date-time":"2019-03-02T05:26:09Z","timestamp":1551504369000},"page":"e024879","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Local prevalence of extended-spectrum beta-lactamase (ESBL) producing <i>Enterobacteriaceae<\/i> intestinal carriers at admission and co-expression of ESBL and OXA-48 carbapenemase in <i>Klebsiella pneumoniae<\/i>: a prevalence survey in a Spanish University Hospital"],"prefix":"10.1136","volume":"9","author":[{"given":"Cristina","family":"D\u00edaz-Agero P\u00e9rez","sequence":"first","affiliation":[{"name":"Servicio de Medicina Preventiva y Salud Publica, Hospital Universitario Ramon y Cajal, Madrid, Spain"},{"name":"Instituto Ram\u00f3n y Cajal de 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