{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:10:27Z","timestamp":1765699827627,"version":"3.48.0"},"reference-count":14,"publisher":"BMJ","issue":"5","funder":[{"name":"Department of Anesthesia and Perioperative Care, University of California San Francisco"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,5,8]]},"published-print":{"date-parts":[[2019,5]]},"abstract":"\n Objective<\/jats:title>\n There is inadequate information about the values of many intraoperative physiological measurements that are associated with improved outcomes after surgery. The purpose of this observational study is to investigate the optimal physiological ranges during major spine surgery.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n A teaching hospital in the USA.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n A convenience sample of 102 patients receiving major posterior spine surgery with multilevel spinal fusion in a prone position.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Physiological variables, including but not limited to mean arterial pressure (MAP) and cerebral and somatic tissue oxygen saturation (SctO\n 2<\/jats:sub>\n \/SstO\n 2<\/jats:sub>\n ), were recorded. The results of these measurements were associated with length of hospital stay and composite complication data and were analysed based on thresholds (ie, a cut-off value for optimal and suboptimal physiology) and the area under the curve (AUC) values. The AUC values were measured as the area enclosed by the actual tracing and the threshold. The outcomes were dichotomised into above-average and below-average (ie, improved) categories.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Analyses based on thresholds identified the following variables associated with above-average outcomes: MAP <60\u2009mm Hg, temperature <35\u00b0C, heart rate >90\u2009beats per minute (bpm), SctO\n 2<\/jats:sub>\n <60% and SstO\n 2<\/jats:sub>\n >80%. Analyses based on AUC values identified the following as associated with above-average outcomes: MAP <70\u2009and >100\u2009mm Hg, temperature <36\u00b0C, heart rate >90\u2009bpm, tidal volume (based on ideal body weight)<6\u2009mL\/kg, tidal volume (based on actual body weight) >10\u2009mL\/kg and peak airway pressure <15 cmH\n 2<\/jats:sub>\n O.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The following physiological ranges are associated with improved outcomes (ie, shorter hospitalisation and fewer complications) during major spine surgery: MAP of 70\u2013100\u2009mm Hg, temperature \u226536\u00b0C, heart rate <90\u2009bpm, tidal volume based on ideal body weight >6\u2009mL\/kg, SctO\n 2<\/jats:sub>\n >60% and SstO\n 2<\/jats:sub>\n <80%.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-025337","type":"journal-article","created":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T08:26:36Z","timestamp":1559118396000},"page":"e025337","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Intraoperative physiological ranges associated with improved outcomes after major spine surgery: an observational study"],"prefix":"10.1136","volume":"9","author":[{"given":"Gang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Peking University Third Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jifang","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Medicine, Georgetown University, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley","family":"Rosenbaum","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Bickler","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingzhong","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,5,28]]},"reference":[{"key":"2025121400071239000_9.5.e025337.1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1213\/ANE.0000000000001348","article-title":"TIssue oximetry and clinical outcomes","volume":"124","author":"Bickler","year":"2017","journal-title":"Anesth Analg"},{"key":"2025121400071239000_9.5.e025337.2","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1161\/HYPERTENSIONAHA.118.11688","article-title":"Blood pressure targets in perioperative care: provisional considerations based on a comprehensive literature review","volume":"72","author":"Meng","year":"2018","journal-title":"Hypertension"},{"key":"2025121400071239000_9.5.e025337.3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/ALN.0000000000001432","article-title":"Relationship between intraoperative hypotension, defined by either reduction from baseline or absolute thresholds, and acute kidney and myocardial injury after noncardiac surgery: A retrospective cohort analysis","volume":"126","author":"Salmasi","year":"2017","journal-title":"Anesthesiology"},{"key":"2025121400071239000_9.5.e025337.4","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3182a10e26"},{"key":"2025121400071239000_9.5.e025337.5","doi-asserted-by":"crossref","unstructured":"Li G , Lin L , Dai F , et al . Muscular tissue oxygen saturation during robotic hysterectomy and postoperative nausea and vomiting: exploring the potential therapeutic thresholds. 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