{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:54:15Z","timestamp":1783072455746,"version":"3.54.6"},"reference-count":25,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,11,23]]},"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyse trends in the number of ultrasound examinations in relation to the effectiveness of prenatal detection of birth defects using population-based data in France.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A multiple registry-based study of time trends in resource use (number of ultrasounds) and effectiveness (proportion of cases prenatally diagnosed).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Three registries of congenital anomalies and claims data on ultrasounds for all pregnant women in France.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>There were two samples of pregnant women. Effectiveness was assessed using data from three French birth defect registries. Resource use for ultrasound screening was based on the French national healthcare database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>The main outcome measures were prenatal diagnosis (effectiveness) and the average number of ultrasounds (resource use). Statistical analyses included linear and logistic regression models to assess trends in resource use and effectiveness of prenatal testing, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The average number of ultrasound examinations per pregnancy significantly increased over the study period, from 2.47 in 2006 to 2.98 in 2014 (p=0.005). However, there was no significant increase in the odds of prenatal diagnosis. The probability of prenatal diagnosis was substantially higher for cases associated with a chromosomal anomaly (91.2%) than those without (51.8%). However, there was no evidence of an increase in prenatal detection of either over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The average number of ultrasound examinations per pregnancy increased over time, whereas the probability of prenatal diagnosis of congenital anomalies did not. Hence, there is a need to implement policies such as high-quality training programmes which can improve the efficiency of ultrasound examinations for prenatal detection of congenital anomalies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-025482","type":"journal-article","created":{"date-parts":[[2019,2,16]],"date-time":"2019-02-16T04:45:25Z","timestamp":1550292325000},"page":"e025482","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Trends in resource use and effectiveness of ultrasound detection of fetal structural anomalies in France: a multiple registry-based study"],"prefix":"10.1136","volume":"9","author":[{"given":"Cl\u00e9ment","family":"Ferrier","sequence":"first","affiliation":[{"name":"Fetal Medicine Department, Sorbonne University, AP-HP, Armand Trousseau Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand","family":"Dhombres","sequence":"additional","affiliation":[{"name":"Fetal Medicine Department, Sorbonne University, AP-HP, Armand Trousseau Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Khoshnood","sequence":"additional","affiliation":[{"name":"INSERM U1142, LIMICS, Sorbonne University, Paris, France"},{"name":"Paris registry of congenital anomalies, Port-Royal Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanitra","family":"Randrianaivo","sequence":"additional","affiliation":[{"name":"Reunion registry of congenital anomalies, St Pierre, Saint Pierre de la R\u00e9union, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Perthus","sequence":"additional","affiliation":[{"name":"Study center for congenital anomalies, CEMC-Auvergne, Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Guilbaut","sequence":"additional","affiliation":[{"name":"Fetal Medicine Department, Sorbonne University, AP-HP, Armand Trousseau Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Durand-Zaleski","sequence":"additional","affiliation":[{"name":"INSERM CRESS UMR 1153, Paris, France"},{"name":"AP-HP, URCEco Ile de France, H\u00f4tel-Dieu Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7890-3790","authenticated-orcid":false,"given":"Jean-Marie","family":"Jouannic","sequence":"additional","affiliation":[{"name":"Fetal Medicine Department, Sorbonne University, AP-HP, Armand Trousseau Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,2,15]]},"reference":[{"key":"2025121512030172000_9.2.e025482.1","first-page":"1","article-title":"Update on overall prevalence of major birth defects--Atlanta, Georgia, 1978-2005","volume":"57","author":"Centers for Disease Control and Prevention (CDC)","year":"2008","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2025121512030172000_9.2.e025482.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01507-1"},{"key":"2025121512030172000_9.2.e025482.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-693X(00)89004-1"},{"key":"2025121512030172000_9.2.e025482.4","first-page":"1","article-title":"Infant mortality statistics from the 2013 period linked birth\/infant death data set","volume":"64","author":"Matthews","year":"2015","journal-title":"Natl Vital Stat Rep"},{"key":"2025121512030172000_9.2.e025482.5","unstructured":"Sureau C , Henrion R . 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